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Development of New Liquid Chromatographic Method for Mitotane and Its Metabolites Determination in Human Plasma Employing Design of Experiments Methodology
(Taylor & Francis Inc, Philadelphia, 2015)
A simple and reliable new HPLC method with UV detection has been developed and validated for simultaneous determination of mitotane and its two metabolites DDA and DDE. Method development was carried out utilizing systematical ...
Assessing the risk of alcohol-induced dose dumping from sustained-release oral dosage forms: in vitro-in silico approach
(Taylor & Francis Ltd, Abingdon, 2018)
Consumption of alcoholic beverages with sustained-release oral dosage forms may pose a risk to patients due to potential alcohol-induced dose dumping (ADD). Regulatory guidances recommend in vitro dissolution testing to ...
In vitro and in vivo investigation of taste-masking effectiveness of Eudragit E PO as drug particle coating agent in orally disintegrating tablets
(Taylor & Francis Ltd, Abingdon, 2017)
Context: Considering that bitter taste of drugs incorporated in orally disintegrating tablets (ODTs) can be the main reason for avoiding drug therapy, it is of the utmost importance to achieve successful taste-masking. The ...
Application of miscibility analysis and determination of Soluplus solubility map for development of carvedilol-loaded nanofibers
(Elsevier, 2017)
Electrospinning was used to produce carvedilol-loaded Soluplus polymer nanofibers using a systematic approach. Miscibility between drug and polymer was determined through calculation of the interaction parameter, chi, and ...
Optimization of TLC method for separation and determination of ziprasidone and its impurities
(Taylor & Francis Inc, Philadelphia, 2016)
A thin-layer chromatographic method for simultaneous determination of ziprasidone and its main impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated ...
Overweight and Obesity in Polycystic Ovary Syndrome: Association with Inflammation, Oxidative Stress and Dyslipidemia
(Cambridge University Press, 2021)
Objective: Polycystic ovary syndrome (PCOS) is associated with altered lipid profile and increased small, dense LDL particles (sdLDL). Considering that paraoxonase 1 (PON1) is an anti-oxidative enzyme located on high-density ...
Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements
(Taylor & Francis Ltd, Abingdon, 2019)
Objective: The aim of this study was to develop, characterize and evaluate stability of a gel containing coenzyme Q(10) (Q(10))-loaded liposomes, and enhance the stability of Q(10) in the nanocarrier-containing gel compared ...
Lactobacillus helveticus lafti L10 supplementation modulates mucosal and humoral immunity in elite athletes: A randomized, double-blind, placebo-controlled trial
(Lippincott Williams & Wilkins, Philadelphia, 2017)
To test the influence of probiotic supplementation on humoral immune response, a double-blind, placebo-controlled trial was conducted. Thirty athletes (24 males and 6 females, females: (V)over dotO(2)max 38.2 +/- 4.9 ...
Prooxidant-antioxidant balance, advanced oxidation protein products and lipid peroxidation in Serbian patients with Parkinson's disease
(Taylor & Francis Ltd, Abingdon, 2018)
Background: Biomarkers of oxidative stress are relevant in the evaluation of the disease status and prooxidant-antioxidant balance, advanced oxidation protein products and lipid peroxidation products (malondialdehyde and ...
Forced degradation study of torasemide: Characterization of its degradation products
(Taylor & Francis Inc, Philadelphia, 2013)
Torasemide was subjected to forced degradation studies. Stress conditions were varied concerning hydrolysis (acid, base, and neutral), oxidation, photolysis, and thermal degradation in order to identify the potential ...