Computer-aided biopharmaceutical characterization: Gastrointestinal absorption simulation
Abstract
This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples are provided throughout the chapter.
Keywords:
Biowaiver / Food effects / Gastrointestinal absorption / In silico modeling / In vitro-in vivo correlation / Parameter sensitivity analysis / Virtual trialsSource:
Computer-Aided Applications in Pharmaceutical Technology, 2013, 177-232Publisher:
- Elsevier Inc.
Collections
Institution/Community
PharmacyTY - CHAP AU - Grbić, Sandra AU - Parojčić, Jelena AU - Đurić, Zorica PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2022 AB - This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples are provided throughout the chapter. PB - Elsevier Inc. T2 - Computer-Aided Applications in Pharmaceutical Technology T1 - Computer-aided biopharmaceutical characterization: Gastrointestinal absorption simulation SP - 177 EP - 232 DO - 10.1016/B978-1-907568-27-5.50006-8 ER -
@inbook{ author = "Grbić, Sandra and Parojčić, Jelena and Đurić, Zorica", year = "2013", abstract = "This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples are provided throughout the chapter.", publisher = "Elsevier Inc.", journal = "Computer-Aided Applications in Pharmaceutical Technology", booktitle = "Computer-aided biopharmaceutical characterization: Gastrointestinal absorption simulation", pages = "177-232", doi = "10.1016/B978-1-907568-27-5.50006-8" }
Grbić, S., Parojčić, J.,& Đurić, Z.. (2013). Computer-aided biopharmaceutical characterization: Gastrointestinal absorption simulation. in Computer-Aided Applications in Pharmaceutical Technology Elsevier Inc.., 177-232. https://doi.org/10.1016/B978-1-907568-27-5.50006-8
Grbić S, Parojčić J, Đurić Z. Computer-aided biopharmaceutical characterization: Gastrointestinal absorption simulation. in Computer-Aided Applications in Pharmaceutical Technology. 2013;:177-232. doi:10.1016/B978-1-907568-27-5.50006-8 .
Grbić, Sandra, Parojčić, Jelena, Đurić, Zorica, "Computer-aided biopharmaceutical characterization: Gastrointestinal absorption simulation" in Computer-Aided Applications in Pharmaceutical Technology (2013):177-232, https://doi.org/10.1016/B978-1-907568-27-5.50006-8 . .