Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients
2014
Аутори
Mirjanić-Azarić, BosaVekić, Jelena
Zeljković, Aleksandra
Jelić-Ivanović, Zorana
Đerić, Mirjana
Milivojac, Tatjana
Fonović, Ursa Pecar
Marc, Janja
Kos, Janko
Cerne, Darko
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Aim: We hypothesized that, in stable angina patients, atorvastatin therapy lowers the cathepsin S (CTSS) concentrations, as assessed non-invasively according to a plasma analysis. In addition, the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in the plasma were analysed to establish the association between CTSS and lipoprotein metabolism and determine whether this association is atorvastatin-sensitive. Methods: A total of 43 patients with stable angina received atorvastatin therapy (20 mg/day, 10 weeks). The plasma CTSS mRNA levels, CTSS protein concentrations and CTSS activity, as well as LDL and HDL size and subclasses, were analysed before and after treatment. Results: Atorvastatin treatment did not change the plasma CTSS mRNA levels, although it lowered the plasma CTSS concentrations and activity. An increased plasma CTSS concentration and activity were found to be associated with a more atherogenic LDL subclass profile (a decreased dominant L...DL size and increased percentage of small, dense LDL particles). The atorvastatin-induced CTSS-lowering effect was concomitant with an improvement in the LDL subclass profile, and the changes were found to be interrelated. Concomitant, interrelated changes in the CTSS levels and LDL subclass profiles were found in the LDL phenotype B patients only (a dominant LDL diameter of lt = 25.5 nm at the start of the study). In this subgroup, lowering of the plasma CTSS mRNA level also correlated with lowering of the proportion of small, dense LDL particles. Conclusions: Atorvastatin-induced CTSS-lowering and LDL subclass profile improvements in the plasma of LDL phenotype B patients with stable angina are concomitant and interrelated.
Кључне речи:
Atorvastatin / Cathepsin S / LDL subclasses / LDL phenotypeИзвор:
Journal of Atherosclerosis and Thrombosis, 2014, 21, 8, 868-877Издавач:
- Japan Atherosclerosis Soc, Tokyo
Финансирање / пројекти:
- Ad Futura - Scientific and Educational Foundation of the Republic of Slovenia, the Slovenian Research Agency, Republic of Slovenia grant P4-0127
DOI: 10.5551/jat.21410
ISSN: 1340-3478
PubMed: 24727728
WoS: 000342071100009
Scopus: 2-s2.0-84906810476
Институција/група
PharmacyTY - JOUR AU - Mirjanić-Azarić, Bosa AU - Vekić, Jelena AU - Zeljković, Aleksandra AU - Jelić-Ivanović, Zorana AU - Đerić, Mirjana AU - Milivojac, Tatjana AU - Fonović, Ursa Pecar AU - Marc, Janja AU - Kos, Janko AU - Cerne, Darko PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2069 AB - Aim: We hypothesized that, in stable angina patients, atorvastatin therapy lowers the cathepsin S (CTSS) concentrations, as assessed non-invasively according to a plasma analysis. In addition, the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in the plasma were analysed to establish the association between CTSS and lipoprotein metabolism and determine whether this association is atorvastatin-sensitive. Methods: A total of 43 patients with stable angina received atorvastatin therapy (20 mg/day, 10 weeks). The plasma CTSS mRNA levels, CTSS protein concentrations and CTSS activity, as well as LDL and HDL size and subclasses, were analysed before and after treatment. Results: Atorvastatin treatment did not change the plasma CTSS mRNA levels, although it lowered the plasma CTSS concentrations and activity. An increased plasma CTSS concentration and activity were found to be associated with a more atherogenic LDL subclass profile (a decreased dominant LDL size and increased percentage of small, dense LDL particles). The atorvastatin-induced CTSS-lowering effect was concomitant with an improvement in the LDL subclass profile, and the changes were found to be interrelated. Concomitant, interrelated changes in the CTSS levels and LDL subclass profiles were found in the LDL phenotype B patients only (a dominant LDL diameter of lt = 25.5 nm at the start of the study). In this subgroup, lowering of the plasma CTSS mRNA level also correlated with lowering of the proportion of small, dense LDL particles. Conclusions: Atorvastatin-induced CTSS-lowering and LDL subclass profile improvements in the plasma of LDL phenotype B patients with stable angina are concomitant and interrelated. PB - Japan Atherosclerosis Soc, Tokyo T2 - Journal of Atherosclerosis and Thrombosis T1 - Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients VL - 21 IS - 8 SP - 868 EP - 877 DO - 10.5551/jat.21410 ER -
@article{ author = "Mirjanić-Azarić, Bosa and Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Đerić, Mirjana and Milivojac, Tatjana and Fonović, Ursa Pecar and Marc, Janja and Kos, Janko and Cerne, Darko", year = "2014", abstract = "Aim: We hypothesized that, in stable angina patients, atorvastatin therapy lowers the cathepsin S (CTSS) concentrations, as assessed non-invasively according to a plasma analysis. In addition, the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in the plasma were analysed to establish the association between CTSS and lipoprotein metabolism and determine whether this association is atorvastatin-sensitive. Methods: A total of 43 patients with stable angina received atorvastatin therapy (20 mg/day, 10 weeks). The plasma CTSS mRNA levels, CTSS protein concentrations and CTSS activity, as well as LDL and HDL size and subclasses, were analysed before and after treatment. Results: Atorvastatin treatment did not change the plasma CTSS mRNA levels, although it lowered the plasma CTSS concentrations and activity. An increased plasma CTSS concentration and activity were found to be associated with a more atherogenic LDL subclass profile (a decreased dominant LDL size and increased percentage of small, dense LDL particles). The atorvastatin-induced CTSS-lowering effect was concomitant with an improvement in the LDL subclass profile, and the changes were found to be interrelated. Concomitant, interrelated changes in the CTSS levels and LDL subclass profiles were found in the LDL phenotype B patients only (a dominant LDL diameter of lt = 25.5 nm at the start of the study). In this subgroup, lowering of the plasma CTSS mRNA level also correlated with lowering of the proportion of small, dense LDL particles. Conclusions: Atorvastatin-induced CTSS-lowering and LDL subclass profile improvements in the plasma of LDL phenotype B patients with stable angina are concomitant and interrelated.", publisher = "Japan Atherosclerosis Soc, Tokyo", journal = "Journal of Atherosclerosis and Thrombosis", title = "Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients", volume = "21", number = "8", pages = "868-877", doi = "10.5551/jat.21410" }
Mirjanić-Azarić, B., Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Đerić, M., Milivojac, T., Fonović, U. P., Marc, J., Kos, J.,& Cerne, D.. (2014). Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients. in Journal of Atherosclerosis and Thrombosis Japan Atherosclerosis Soc, Tokyo., 21(8), 868-877. https://doi.org/10.5551/jat.21410
Mirjanić-Azarić B, Vekić J, Zeljković A, Jelić-Ivanović Z, Đerić M, Milivojac T, Fonović UP, Marc J, Kos J, Cerne D. Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients. in Journal of Atherosclerosis and Thrombosis. 2014;21(8):868-877. doi:10.5551/jat.21410 .
Mirjanić-Azarić, Bosa, Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Đerić, Mirjana, Milivojac, Tatjana, Fonović, Ursa Pecar, Marc, Janja, Kos, Janko, Cerne, Darko, "Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients" in Journal of Atherosclerosis and Thrombosis, 21, no. 8 (2014):868-877, https://doi.org/10.5551/jat.21410 . .