Improvement of trospium-specific absorption models for fasted and fed states in humans
Abstract
The purpose of this study was to mechanistically interpret the oral absorption pattern of trospium in fasted and fed states by means of gastrointestinal simulation technology. A drug absorption model was built on the basis of experimental data. According to the generated model, low permeability across the intestinal epithelium, delayed gastric emptying time and a prolonged residence time in the small intestine are the key factors governing trospium absorption in the fasted state. Furthermore, in silico modelling provided a plausible explanation of the pronounced reduction in the oral bioavailability of trospium when administered with food. The simulation results support the decreased dissolution in viscous medium, and the reduced drug permeability in the fed state as the predominant mechanisms for the food effect on trospium absorption. Copyright
Keywords:
trospium / absorption simulation / food effect / viscosity / bile saltsSource:
Biopharmaceutics & Drug Disposition, 2014, 35, 9, 553-558Publisher:
- Wiley-Blackwell, Hoboken
Funding / projects:
- German Academic Exchange Service (DAAD) A/12/85086
DOI: 10.1002/bdd.1911
ISSN: 0142-2782
PubMed: 25044357
WoS: 000346582500006
Scopus: 2-s2.0-84919951296
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Institution/Community
PharmacyTY - JOUR AU - Cvijić, Sandra AU - Langguth, Peter PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2108 AB - The purpose of this study was to mechanistically interpret the oral absorption pattern of trospium in fasted and fed states by means of gastrointestinal simulation technology. A drug absorption model was built on the basis of experimental data. According to the generated model, low permeability across the intestinal epithelium, delayed gastric emptying time and a prolonged residence time in the small intestine are the key factors governing trospium absorption in the fasted state. Furthermore, in silico modelling provided a plausible explanation of the pronounced reduction in the oral bioavailability of trospium when administered with food. The simulation results support the decreased dissolution in viscous medium, and the reduced drug permeability in the fed state as the predominant mechanisms for the food effect on trospium absorption. Copyright PB - Wiley-Blackwell, Hoboken T2 - Biopharmaceutics & Drug Disposition T1 - Improvement of trospium-specific absorption models for fasted and fed states in humans VL - 35 IS - 9 SP - 553 EP - 558 DO - 10.1002/bdd.1911 ER -
@article{ author = "Cvijić, Sandra and Langguth, Peter", year = "2014", abstract = "The purpose of this study was to mechanistically interpret the oral absorption pattern of trospium in fasted and fed states by means of gastrointestinal simulation technology. A drug absorption model was built on the basis of experimental data. According to the generated model, low permeability across the intestinal epithelium, delayed gastric emptying time and a prolonged residence time in the small intestine are the key factors governing trospium absorption in the fasted state. Furthermore, in silico modelling provided a plausible explanation of the pronounced reduction in the oral bioavailability of trospium when administered with food. The simulation results support the decreased dissolution in viscous medium, and the reduced drug permeability in the fed state as the predominant mechanisms for the food effect on trospium absorption. Copyright", publisher = "Wiley-Blackwell, Hoboken", journal = "Biopharmaceutics & Drug Disposition", title = "Improvement of trospium-specific absorption models for fasted and fed states in humans", volume = "35", number = "9", pages = "553-558", doi = "10.1002/bdd.1911" }
Cvijić, S.,& Langguth, P.. (2014). Improvement of trospium-specific absorption models for fasted and fed states in humans. in Biopharmaceutics & Drug Disposition Wiley-Blackwell, Hoboken., 35(9), 553-558. https://doi.org/10.1002/bdd.1911
Cvijić S, Langguth P. Improvement of trospium-specific absorption models for fasted and fed states in humans. in Biopharmaceutics & Drug Disposition. 2014;35(9):553-558. doi:10.1002/bdd.1911 .
Cvijić, Sandra, Langguth, Peter, "Improvement of trospium-specific absorption models for fasted and fed states in humans" in Biopharmaceutics & Drug Disposition, 35, no. 9 (2014):553-558, https://doi.org/10.1002/bdd.1911 . .