Cost-Minimisation Analysis of Colistimethate Sodium in Serbia- off Label Use Approach
Apstrakt
Objectives: Colistimethate sodium (Colistin) is an old, “forgotten” antibiotics
revived due to multidrug-resistant Gram-negative bacteria in nosocomial infec-
tions. In many countries, both – intravenous and inhalational administrations of
Colistin have marketing authorisation. In Serbia, Colistin is registered only for
intravenous administration. Therefore, inhalational administration of Colistin in
treatment for cystic fibrosis is considered as off label use. AiM: The purpose of
this study was to assess benefits of Colistin off label use, currently available in
Serbia, for treatment for cystic fibrosis. MethOds: Data collected from a review
of the literature (Pubmed searching key word off label, Colistin, Tobramycine, cost
minimisation) and data from Health Insurance Fond of Republic Serbia (2014)
were used to perform a cost-minimisation analysis comparing DDD in inhalation
administration of Colistin with Tobramycin (official methodology in Serbia for drug
reimbursement L...isting). Results: Both, Colistin and Tobramycine are effective
in cystic fibrosis treatment. The cost of treatment per patient per year in Serbia is
3 616,00 Euro for Colistin and 5 950,00 Euro for Tobramycin. Total savings per year
for 200 registered patients in Serbia could be 466 857,00 Euro. cOnclusiOns:
Given cost-minimisation analysis justified the treatment with Colistin as cost
saving therapeutic alternative to Tobramycin for cystic fibrosis patients in Serbia.
The lack of guidelines and principles regarding off label medicine use in health
care policy and decision making in Serbia was evidently an obstacle for better
patients care.
Izvor:
Value in Health, 2014, 17, 7, A399-A399Izdavač:
- Elsevier Science Inc
DOI: 10.1016/j.jval.2014.08.904
ISSN: 1098-3015
PubMed: 27200947
WoS: 000346917300420
[ Google Scholar ]Institucija/grupa
PharmacyTY - CONF AU - Đorđević, J. AU - Mitrović, M. AU - Marinković, Valentina AU - Tasić, Ljiljana AU - Krajnović, Dušanka PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2109 AB - Objectives: Colistimethate sodium (Colistin) is an old, “forgotten” antibiotics revived due to multidrug-resistant Gram-negative bacteria in nosocomial infec- tions. In many countries, both – intravenous and inhalational administrations of Colistin have marketing authorisation. In Serbia, Colistin is registered only for intravenous administration. Therefore, inhalational administration of Colistin in treatment for cystic fibrosis is considered as off label use. AiM: The purpose of this study was to assess benefits of Colistin off label use, currently available in Serbia, for treatment for cystic fibrosis. MethOds: Data collected from a review of the literature (Pubmed searching key word off label, Colistin, Tobramycine, cost minimisation) and data from Health Insurance Fond of Republic Serbia (2014) were used to perform a cost-minimisation analysis comparing DDD in inhalation administration of Colistin with Tobramycin (official methodology in Serbia for drug reimbursement Listing). Results: Both, Colistin and Tobramycine are effective in cystic fibrosis treatment. The cost of treatment per patient per year in Serbia is 3 616,00 Euro for Colistin and 5 950,00 Euro for Tobramycin. Total savings per year for 200 registered patients in Serbia could be 466 857,00 Euro. cOnclusiOns: Given cost-minimisation analysis justified the treatment with Colistin as cost saving therapeutic alternative to Tobramycin for cystic fibrosis patients in Serbia. The lack of guidelines and principles regarding off label medicine use in health care policy and decision making in Serbia was evidently an obstacle for better patients care. PB - Elsevier Science Inc C3 - Value in Health T1 - Cost-Minimisation Analysis of Colistimethate Sodium in Serbia- off Label Use Approach VL - 17 IS - 7 SP - A399 EP - A399 DO - 10.1016/j.jval.2014.08.904 ER -
@conference{ author = "Đorđević, J. and Mitrović, M. and Marinković, Valentina and Tasić, Ljiljana and Krajnović, Dušanka", year = "2014", abstract = "Objectives: Colistimethate sodium (Colistin) is an old, “forgotten” antibiotics revived due to multidrug-resistant Gram-negative bacteria in nosocomial infec- tions. In many countries, both – intravenous and inhalational administrations of Colistin have marketing authorisation. In Serbia, Colistin is registered only for intravenous administration. Therefore, inhalational administration of Colistin in treatment for cystic fibrosis is considered as off label use. AiM: The purpose of this study was to assess benefits of Colistin off label use, currently available in Serbia, for treatment for cystic fibrosis. MethOds: Data collected from a review of the literature (Pubmed searching key word off label, Colistin, Tobramycine, cost minimisation) and data from Health Insurance Fond of Republic Serbia (2014) were used to perform a cost-minimisation analysis comparing DDD in inhalation administration of Colistin with Tobramycin (official methodology in Serbia for drug reimbursement Listing). Results: Both, Colistin and Tobramycine are effective in cystic fibrosis treatment. The cost of treatment per patient per year in Serbia is 3 616,00 Euro for Colistin and 5 950,00 Euro for Tobramycin. Total savings per year for 200 registered patients in Serbia could be 466 857,00 Euro. cOnclusiOns: Given cost-minimisation analysis justified the treatment with Colistin as cost saving therapeutic alternative to Tobramycin for cystic fibrosis patients in Serbia. The lack of guidelines and principles regarding off label medicine use in health care policy and decision making in Serbia was evidently an obstacle for better patients care.", publisher = "Elsevier Science Inc", journal = "Value in Health", title = "Cost-Minimisation Analysis of Colistimethate Sodium in Serbia- off Label Use Approach", volume = "17", number = "7", pages = "A399-A399", doi = "10.1016/j.jval.2014.08.904" }
Đorđević, J., Mitrović, M., Marinković, V., Tasić, L.,& Krajnović, D.. (2014). Cost-Minimisation Analysis of Colistimethate Sodium in Serbia- off Label Use Approach. in Value in Health Elsevier Science Inc., 17(7), A399-A399. https://doi.org/10.1016/j.jval.2014.08.904
Đorđević J, Mitrović M, Marinković V, Tasić L, Krajnović D. Cost-Minimisation Analysis of Colistimethate Sodium in Serbia- off Label Use Approach. in Value in Health. 2014;17(7):A399-A399. doi:10.1016/j.jval.2014.08.904 .
Đorđević, J., Mitrović, M., Marinković, Valentina, Tasić, Ljiljana, Krajnović, Dušanka, "Cost-Minimisation Analysis of Colistimethate Sodium in Serbia- off Label Use Approach" in Value in Health, 17, no. 7 (2014):A399-A399, https://doi.org/10.1016/j.jval.2014.08.904 . .