Comparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impurities
Samo za registrovane korisnike
2014
Autori
Rakić, TijanaKasagić-Vujanović, Irena
Jovanović, Marko
Jančić-Stojanović, Biljana
Ivanović, Darko
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This paper presents the development and optimization of a liquid chromatographic method for the determination of fluconazole and its impurities by experimental design methodology. Four experimental design types were applied: two-level full factorial design, central composite design, Box-Behnken design, and three-level full factorial design. The advantages and drawbacks of each design are described and detailed statistical evaluation of mathematical models was performed. The central composite design and three-level full factorial design created significantly better models comparing to the other methods. As the central composite design requires a smaller number of experiments, its models were used for theoretical examination of experimental space. Multiobjective optimization aiming to achieve maximal separation of all investigated substances and minimal analysis duration was performed by a grid point search. The defined optimal separation was achieved on a C-18 (125mmx4mm, 5 mu m particl...e size) column with a mobile phase consisting of acetonitrile and water (5mM ammonium formate) (15:85, v/v); a column temperature of 25 degrees C; a flow rate of 1.2mLmin(-1); and a detection wavelength of 260nm.
Ključne reči:
Chemometrics / Experimental design / Fluconazole / Impurities / Liquid chromatographyIzvor:
Analytical Letters, 2014, 47, 8, 1334-1347Izdavač:
- Taylor & Francis Inc, Philadelphia
Finansiranje / projekti:
- Modelovanje različitih hromatografskih sistema sa hemometrijskim pristupom u farmaceutskoj analizi (RS-172052)
DOI: 10.1080/00032719.2013.867503
ISSN: 0003-2719
WoS: 000335214700005
Scopus: 2-s2.0-84899735672
Institucija/grupa
PharmacyTY - JOUR AU - Rakić, Tijana AU - Kasagić-Vujanović, Irena AU - Jovanović, Marko AU - Jančić-Stojanović, Biljana AU - Ivanović, Darko PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2223 AB - This paper presents the development and optimization of a liquid chromatographic method for the determination of fluconazole and its impurities by experimental design methodology. Four experimental design types were applied: two-level full factorial design, central composite design, Box-Behnken design, and three-level full factorial design. The advantages and drawbacks of each design are described and detailed statistical evaluation of mathematical models was performed. The central composite design and three-level full factorial design created significantly better models comparing to the other methods. As the central composite design requires a smaller number of experiments, its models were used for theoretical examination of experimental space. Multiobjective optimization aiming to achieve maximal separation of all investigated substances and minimal analysis duration was performed by a grid point search. The defined optimal separation was achieved on a C-18 (125mmx4mm, 5 mu m particle size) column with a mobile phase consisting of acetonitrile and water (5mM ammonium formate) (15:85, v/v); a column temperature of 25 degrees C; a flow rate of 1.2mLmin(-1); and a detection wavelength of 260nm. PB - Taylor & Francis Inc, Philadelphia T2 - Analytical Letters T1 - Comparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impurities VL - 47 IS - 8 SP - 1334 EP - 1347 DO - 10.1080/00032719.2013.867503 ER -
@article{ author = "Rakić, Tijana and Kasagić-Vujanović, Irena and Jovanović, Marko and Jančić-Stojanović, Biljana and Ivanović, Darko", year = "2014", abstract = "This paper presents the development and optimization of a liquid chromatographic method for the determination of fluconazole and its impurities by experimental design methodology. Four experimental design types were applied: two-level full factorial design, central composite design, Box-Behnken design, and three-level full factorial design. The advantages and drawbacks of each design are described and detailed statistical evaluation of mathematical models was performed. The central composite design and three-level full factorial design created significantly better models comparing to the other methods. As the central composite design requires a smaller number of experiments, its models were used for theoretical examination of experimental space. Multiobjective optimization aiming to achieve maximal separation of all investigated substances and minimal analysis duration was performed by a grid point search. The defined optimal separation was achieved on a C-18 (125mmx4mm, 5 mu m particle size) column with a mobile phase consisting of acetonitrile and water (5mM ammonium formate) (15:85, v/v); a column temperature of 25 degrees C; a flow rate of 1.2mLmin(-1); and a detection wavelength of 260nm.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Analytical Letters", title = "Comparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impurities", volume = "47", number = "8", pages = "1334-1347", doi = "10.1080/00032719.2013.867503" }
Rakić, T., Kasagić-Vujanović, I., Jovanović, M., Jančić-Stojanović, B.,& Ivanović, D.. (2014). Comparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impurities. in Analytical Letters Taylor & Francis Inc, Philadelphia., 47(8), 1334-1347. https://doi.org/10.1080/00032719.2013.867503
Rakić T, Kasagić-Vujanović I, Jovanović M, Jančić-Stojanović B, Ivanović D. Comparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impurities. in Analytical Letters. 2014;47(8):1334-1347. doi:10.1080/00032719.2013.867503 .
Rakić, Tijana, Kasagić-Vujanović, Irena, Jovanović, Marko, Jančić-Stojanović, Biljana, Ivanović, Darko, "Comparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impurities" in Analytical Letters, 47, no. 8 (2014):1334-1347, https://doi.org/10.1080/00032719.2013.867503 . .