Effects of flavonoids on plasma coagulation tested in vitro by "screening tests"
Апстракт
The effects of four flavonoids: rutin, quercetin, morin and hesperidin on plasma coagulation has been examined by measuring aPTT, TT and PT. It is found that water solution of these flavonoids shows no effects in the measured quantities. This is due to their low solubility in water, and therefore, their low concentrations. Ethanolic solutions of these studied flavonoids, however, show significant prolongation of all measured coagulation times, but compared to ethanol alone, their anticoagulant effects are smaller. It is suggested that the observed effects can be attributed to the interaction of flavonoids with human plasma proteins.
Извор:
Jugoslovenska medicinska biohemija, 1999, 18, 4, 167-169Издавач:
- Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
Институција/група
PharmacyTY - JOUR AU - Kuntić, Vesna AU - Filipović-Ljesković, L AU - Malešev, Dušan AU - Jelić, S PY - 1999 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/227 AB - The effects of four flavonoids: rutin, quercetin, morin and hesperidin on plasma coagulation has been examined by measuring aPTT, TT and PT. It is found that water solution of these flavonoids shows no effects in the measured quantities. This is due to their low solubility in water, and therefore, their low concentrations. Ethanolic solutions of these studied flavonoids, however, show significant prolongation of all measured coagulation times, but compared to ethanol alone, their anticoagulant effects are smaller. It is suggested that the observed effects can be attributed to the interaction of flavonoids with human plasma proteins. PB - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd T2 - Jugoslovenska medicinska biohemija T1 - Effects of flavonoids on plasma coagulation tested in vitro by "screening tests" VL - 18 IS - 4 SP - 167 EP - 169 UR - https://hdl.handle.net/21.15107/rcub_farfar_227 ER -
@article{ author = "Kuntić, Vesna and Filipović-Ljesković, L and Malešev, Dušan and Jelić, S", year = "1999", abstract = "The effects of four flavonoids: rutin, quercetin, morin and hesperidin on plasma coagulation has been examined by measuring aPTT, TT and PT. It is found that water solution of these flavonoids shows no effects in the measured quantities. This is due to their low solubility in water, and therefore, their low concentrations. Ethanolic solutions of these studied flavonoids, however, show significant prolongation of all measured coagulation times, but compared to ethanol alone, their anticoagulant effects are smaller. It is suggested that the observed effects can be attributed to the interaction of flavonoids with human plasma proteins.", publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd", journal = "Jugoslovenska medicinska biohemija", title = "Effects of flavonoids on plasma coagulation tested in vitro by "screening tests"", volume = "18", number = "4", pages = "167-169", url = "https://hdl.handle.net/21.15107/rcub_farfar_227" }
Kuntić, V., Filipović-Ljesković, L., Malešev, D.,& Jelić, S.. (1999). Effects of flavonoids on plasma coagulation tested in vitro by "screening tests". in Jugoslovenska medicinska biohemija Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 18(4), 167-169. https://hdl.handle.net/21.15107/rcub_farfar_227
Kuntić V, Filipović-Ljesković L, Malešev D, Jelić S. Effects of flavonoids on plasma coagulation tested in vitro by "screening tests". in Jugoslovenska medicinska biohemija. 1999;18(4):167-169. https://hdl.handle.net/21.15107/rcub_farfar_227 .
Kuntić, Vesna, Filipović-Ljesković, L, Malešev, Dušan, Jelić, S, "Effects of flavonoids on plasma coagulation tested in vitro by "screening tests"" in Jugoslovenska medicinska biohemija, 18, no. 4 (1999):167-169, https://hdl.handle.net/21.15107/rcub_farfar_227 .