Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers
Abstract
The sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants - benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to similar to 40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination ...of drug diffusion and ion exchange as the predominant release mechanisms.
Keywords:
clinoptilolite / cationic surfactants / sorption / excipient / ibuprofen / dissolutionSource:
Clay Minerals, 2015, 50, 1, 11-22Publisher:
- Mineralogical Soc, Twickenham
Funding / projects:
DOI: 10.1180/claymin.2015.050.1.02
ISSN: 0009-8558
WoS: 000362443100003
Scopus: 2-s2.0-84943771022
Collections
Institution/Community
PharmacyTY - JOUR AU - Krajišnik, Danina AU - Daković, Aleksandra AU - Malenović, Anđelija AU - Kragović, Milan AU - Milić, Jela PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2327 AB - The sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants - benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to similar to 40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms. PB - Mineralogical Soc, Twickenham T2 - Clay Minerals T1 - Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers VL - 50 IS - 1 SP - 11 EP - 22 DO - 10.1180/claymin.2015.050.1.02 ER -
@article{ author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Kragović, Milan and Milić, Jela", year = "2015", abstract = "The sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants - benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to similar to 40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms.", publisher = "Mineralogical Soc, Twickenham", journal = "Clay Minerals", title = "Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers", volume = "50", number = "1", pages = "11-22", doi = "10.1180/claymin.2015.050.1.02" }
Krajišnik, D., Daković, A., Malenović, A., Kragović, M.,& Milić, J.. (2015). Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers. in Clay Minerals Mineralogical Soc, Twickenham., 50(1), 11-22. https://doi.org/10.1180/claymin.2015.050.1.02
Krajišnik D, Daković A, Malenović A, Kragović M, Milić J. Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers. in Clay Minerals. 2015;50(1):11-22. doi:10.1180/claymin.2015.050.1.02 .
Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Kragović, Milan, Milić, Jela, "Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers" in Clay Minerals, 50, no. 1 (2015):11-22, https://doi.org/10.1180/claymin.2015.050.1.02 . .