Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites
Samo za registrovane korisnike
2015
Autori
Pavlović, IvanPetrović, Silvana
Milenković, Marina
Stanojković, Tatjana
Nikolić, Dejan
Krunić, Aleksej
Niketić, Marjan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffeliiGriseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5g/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5g/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2M, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5M, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2M). The cytotoxi...c activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 lt 11.0g/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50=22.32 +/- 1.32 vs. 18.67 +/- 0.75M).
Izvor:
Chemistry & Biodiversity, 2015, 12, 10, 1585-1594Izdavač:
- Wiley-VCH Verlag GMBH, Weinheim
Finansiranje / projekti:
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-MESTD-Basic Research (BR or ON)-173021)
DOI: 10.1002/cbdv.201400400
ISSN: 1612-1872
PubMed: 26460563
WoS: 000362956100010
Scopus: 2-s2.0-84943794133
Institucija/grupa
PharmacyTY - JOUR AU - Pavlović, Ivan AU - Petrović, Silvana AU - Milenković, Marina AU - Stanojković, Tatjana AU - Nikolić, Dejan AU - Krunić, Aleksej AU - Niketić, Marjan PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2330 AB - The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffeliiGriseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5g/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5g/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2M, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5M, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2M). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 lt 11.0g/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50=22.32 +/- 1.32 vs. 18.67 +/- 0.75M). PB - Wiley-VCH Verlag GMBH, Weinheim T2 - Chemistry & Biodiversity T1 - Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites VL - 12 IS - 10 SP - 1585 EP - 1594 DO - 10.1002/cbdv.201400400 ER -
@article{ author = "Pavlović, Ivan and Petrović, Silvana and Milenković, Marina and Stanojković, Tatjana and Nikolić, Dejan and Krunić, Aleksej and Niketić, Marjan", year = "2015", abstract = "The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffeliiGriseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5g/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5g/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2M, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5M, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2M). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 lt 11.0g/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50=22.32 +/- 1.32 vs. 18.67 +/- 0.75M).", publisher = "Wiley-VCH Verlag GMBH, Weinheim", journal = "Chemistry & Biodiversity", title = "Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites", volume = "12", number = "10", pages = "1585-1594", doi = "10.1002/cbdv.201400400" }
Pavlović, I., Petrović, S., Milenković, M., Stanojković, T., Nikolić, D., Krunić, A.,& Niketić, M.. (2015). Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites. in Chemistry & Biodiversity Wiley-VCH Verlag GMBH, Weinheim., 12(10), 1585-1594. https://doi.org/10.1002/cbdv.201400400
Pavlović I, Petrović S, Milenković M, Stanojković T, Nikolić D, Krunić A, Niketić M. Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites. in Chemistry & Biodiversity. 2015;12(10):1585-1594. doi:10.1002/cbdv.201400400 .
Pavlović, Ivan, Petrović, Silvana, Milenković, Marina, Stanojković, Tatjana, Nikolić, Dejan, Krunić, Aleksej, Niketić, Marjan, "Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites" in Chemistry & Biodiversity, 12, no. 10 (2015):1585-1594, https://doi.org/10.1002/cbdv.201400400 . .