The retention behavior of several semisynthetic cephalosporins in planar chromatography
Abstract
The chromatographic behavior of cephalexine, cefaclore, ceftriaxone, cefiuime, and cefotaxime has been investigated on silica gel layers with binary mobile phases containing different amounts of organic modifier. The influence of type, chemical character, and position of substitution of functional groups (steric and structural effects) on the retention of analyzed compounds was of particular interest. Systematic investigation of the cephalosporins furnished much information about their hydrophobicity (R-M(0)), the mechanism of adsorption, and the possibilities of separation. Correlation of the hydrophobicity parameters R-M(0), m, and C-0 with the lipophilicity parameter log P was established by use of linear equations. The parameter C-0 was considered as directly applicable in quantitative structure-activity relationships of the cephalosporins.
Keywords:
Cephalosporins / Hydrophobicity (R(M) 0 , m, and C 0 ) / Lipophilicity (log P) / Mechanism of adsorption / Quantitative structure-activity relationships (QSAR)Source:
Journal of Planar Chromatography - Modern TLC, 2000, 13, 2, 88-92Publisher:
- Springer Hungarica Kiado Kft, Budapest
Collections
Institution/Community
PharmacyTY - JOUR AU - Erić, Slavica AU - Agbaba, Danica AU - Vladimirov, S AU - Živanov-Stakić, Dobrila PY - 2000 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/237 AB - The chromatographic behavior of cephalexine, cefaclore, ceftriaxone, cefiuime, and cefotaxime has been investigated on silica gel layers with binary mobile phases containing different amounts of organic modifier. The influence of type, chemical character, and position of substitution of functional groups (steric and structural effects) on the retention of analyzed compounds was of particular interest. Systematic investigation of the cephalosporins furnished much information about their hydrophobicity (R-M(0)), the mechanism of adsorption, and the possibilities of separation. Correlation of the hydrophobicity parameters R-M(0), m, and C-0 with the lipophilicity parameter log P was established by use of linear equations. The parameter C-0 was considered as directly applicable in quantitative structure-activity relationships of the cephalosporins. PB - Springer Hungarica Kiado Kft, Budapest T2 - Journal of Planar Chromatography - Modern TLC T1 - The retention behavior of several semisynthetic cephalosporins in planar chromatography VL - 13 IS - 2 SP - 88 EP - 92 UR - https://hdl.handle.net/21.15107/rcub_farfar_237 ER -
@article{ author = "Erić, Slavica and Agbaba, Danica and Vladimirov, S and Živanov-Stakić, Dobrila", year = "2000", abstract = "The chromatographic behavior of cephalexine, cefaclore, ceftriaxone, cefiuime, and cefotaxime has been investigated on silica gel layers with binary mobile phases containing different amounts of organic modifier. The influence of type, chemical character, and position of substitution of functional groups (steric and structural effects) on the retention of analyzed compounds was of particular interest. Systematic investigation of the cephalosporins furnished much information about their hydrophobicity (R-M(0)), the mechanism of adsorption, and the possibilities of separation. Correlation of the hydrophobicity parameters R-M(0), m, and C-0 with the lipophilicity parameter log P was established by use of linear equations. The parameter C-0 was considered as directly applicable in quantitative structure-activity relationships of the cephalosporins.", publisher = "Springer Hungarica Kiado Kft, Budapest", journal = "Journal of Planar Chromatography - Modern TLC", title = "The retention behavior of several semisynthetic cephalosporins in planar chromatography", volume = "13", number = "2", pages = "88-92", url = "https://hdl.handle.net/21.15107/rcub_farfar_237" }
Erić, S., Agbaba, D., Vladimirov, S.,& Živanov-Stakić, D.. (2000). The retention behavior of several semisynthetic cephalosporins in planar chromatography. in Journal of Planar Chromatography - Modern TLC Springer Hungarica Kiado Kft, Budapest., 13(2), 88-92. https://hdl.handle.net/21.15107/rcub_farfar_237
Erić S, Agbaba D, Vladimirov S, Živanov-Stakić D. The retention behavior of several semisynthetic cephalosporins in planar chromatography. in Journal of Planar Chromatography - Modern TLC. 2000;13(2):88-92. https://hdl.handle.net/21.15107/rcub_farfar_237 .
Erić, Slavica, Agbaba, Danica, Vladimirov, S, Živanov-Stakić, Dobrila, "The retention behavior of several semisynthetic cephalosporins in planar chromatography" in Journal of Planar Chromatography - Modern TLC, 13, no. 2 (2000):88-92, https://hdl.handle.net/21.15107/rcub_farfar_237 .