Chemical composition and biological activity of the plum seed extract
Hemijski sastav i biološka aktivnost ekstrakta semena šljive
2016
Authors
Savić, IvanNikolić, Vesna D.
Savić-Gajić, Ivana
Kundaković, Tatjana
Stanojković, Tatjana
Najman, Stevo J.
Article (Published version)
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The aim of this paper was to estimate the biological activity of the plum seed extract and to define the chemical composition by using the ESI-MS method. During the investigation of the antioxidant activity, the extract showed a better ability to inhibit DPPH radicals compared with amygdalin standard. The results of the antimicrobial study indicate that the extract has a greater effect on Gram-negative bacteria compared with amygdalin. Gram-positive bacteria and fungi remained resistant in both cases. Unlike amygdalin, the extract showed a greater antimicrobial activity against the same microbiological strains. Amygdalin was isolated from the extract before the investigation of antiproliferative activity against MDA-MB-361, MDA-MB-453, HeLa and LS174 cell lines using MTT assay. Unlike the MDA-MB-453 cell line, the activity of standard and isolated amygdalin was not observed at the concentrations lower than 400 μg cm-3 on MDA-MB-361 cell line. The isolated amygdalin has not shown the ac...tivity in other cell lines. The antiproliferative activity of amygdalin standard was also noticed on HeLa and LS-174 cell lines at the concentrations of 333.27 and 333.17 μg cm-3, respectively.
Cilj ovog rada bila je procena biološke aktivnosti ekstrakta semena šljive i definisanje hemijskog sastava primenom ESI-MS metode. Tokom ispitivanja antioksidativne aktivnosti, ekstrakt je pokazao bolju sposobnost inhibiranja DPPH radikala u poređenju sa standardom amigdalina. Rezultati antimikrobne studije pokazali su da ekstrakt ima veći uticaj na rast Gram-negativnih bakterija u odnosnu na amigdalin. Gram-pozitivne bakterije i gljivice ostale su rezistentne u oba slučaja. Za razliku od amigdalina, ekstrakt je pokazao veću antimikrobnu aktivnost na iste sojeve mikroorganizama. Amigdalin je izolovan iz ekstrakta pre ispitivanja antiproliferativne aktivnosti na MDA-MB-361, MDA-MB-453, HeLa i LS174 ćelijskim linijama upotrebom MTT testa. Za razliku od MDA-MB-453 ćelijskih linija, aktivnost standarda i izolovanog amigdalina nije uočena na MDA-MB-361 ćelijskim linijama pri koncentracijama nižim od 400 μg cm-3. Izolovani amigdalin nije pokazao aktivnost na ostalim ćelijskim linijama. Antip...roliferativna aktivnost standarda amigdalina uočena je i na HeLa i LS-174 ćelijskim linijama pri koncentracijama 333.27 i 333.17 μg cm-3, respektivno.
Keywords:
plum seeds / amygdalin / antioxidant activity / antimicrobial activity / antiproliferative activity / seme šljive / amigdalin / antioksidativna aktivnost / antimikrobna aktivnost / antiproliferativna aktivnostSource:
Advanced Technologies, 2016, 5, 2, 38-45Publisher:
- Univerzitet u Nišu - Tehnološki fakultet, Leskovac
Funding / projects:
- Plants and synthetic bioactive products of new generation (RS-MESTD-Technological Development (TD or TR)-34012)
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Institution/Community
PharmacyTY - JOUR AU - Savić, Ivan AU - Nikolić, Vesna D. AU - Savić-Gajić, Ivana AU - Kundaković, Tatjana AU - Stanojković, Tatjana AU - Najman, Stevo J. PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2529 AB - The aim of this paper was to estimate the biological activity of the plum seed extract and to define the chemical composition by using the ESI-MS method. During the investigation of the antioxidant activity, the extract showed a better ability to inhibit DPPH radicals compared with amygdalin standard. The results of the antimicrobial study indicate that the extract has a greater effect on Gram-negative bacteria compared with amygdalin. Gram-positive bacteria and fungi remained resistant in both cases. Unlike amygdalin, the extract showed a greater antimicrobial activity against the same microbiological strains. Amygdalin was isolated from the extract before the investigation of antiproliferative activity against MDA-MB-361, MDA-MB-453, HeLa and LS174 cell lines using MTT assay. Unlike the MDA-MB-453 cell line, the activity of standard and isolated amygdalin was not observed at the concentrations lower than 400 μg cm-3 on MDA-MB-361 cell line. The isolated amygdalin has not shown the activity in other cell lines. The antiproliferative activity of amygdalin standard was also noticed on HeLa and LS-174 cell lines at the concentrations of 333.27 and 333.17 μg cm-3, respectively. AB - Cilj ovog rada bila je procena biološke aktivnosti ekstrakta semena šljive i definisanje hemijskog sastava primenom ESI-MS metode. Tokom ispitivanja antioksidativne aktivnosti, ekstrakt je pokazao bolju sposobnost inhibiranja DPPH radikala u poređenju sa standardom amigdalina. Rezultati antimikrobne studije pokazali su da ekstrakt ima veći uticaj na rast Gram-negativnih bakterija u odnosnu na amigdalin. Gram-pozitivne bakterije i gljivice ostale su rezistentne u oba slučaja. Za razliku od amigdalina, ekstrakt je pokazao veću antimikrobnu aktivnost na iste sojeve mikroorganizama. Amigdalin je izolovan iz ekstrakta pre ispitivanja antiproliferativne aktivnosti na MDA-MB-361, MDA-MB-453, HeLa i LS174 ćelijskim linijama upotrebom MTT testa. Za razliku od MDA-MB-453 ćelijskih linija, aktivnost standarda i izolovanog amigdalina nije uočena na MDA-MB-361 ćelijskim linijama pri koncentracijama nižim od 400 μg cm-3. Izolovani amigdalin nije pokazao aktivnost na ostalim ćelijskim linijama. Antiproliferativna aktivnost standarda amigdalina uočena je i na HeLa i LS-174 ćelijskim linijama pri koncentracijama 333.27 i 333.17 μg cm-3, respektivno. PB - Univerzitet u Nišu - Tehnološki fakultet, Leskovac T2 - Advanced Technologies T1 - Chemical composition and biological activity of the plum seed extract T1 - Hemijski sastav i biološka aktivnost ekstrakta semena šljive VL - 5 IS - 2 SP - 38 EP - 45 DO - 10.5937/savteh1602038S ER -
@article{ author = "Savić, Ivan and Nikolić, Vesna D. and Savić-Gajić, Ivana and Kundaković, Tatjana and Stanojković, Tatjana and Najman, Stevo J.", year = "2016", abstract = "The aim of this paper was to estimate the biological activity of the plum seed extract and to define the chemical composition by using the ESI-MS method. During the investigation of the antioxidant activity, the extract showed a better ability to inhibit DPPH radicals compared with amygdalin standard. The results of the antimicrobial study indicate that the extract has a greater effect on Gram-negative bacteria compared with amygdalin. Gram-positive bacteria and fungi remained resistant in both cases. Unlike amygdalin, the extract showed a greater antimicrobial activity against the same microbiological strains. Amygdalin was isolated from the extract before the investigation of antiproliferative activity against MDA-MB-361, MDA-MB-453, HeLa and LS174 cell lines using MTT assay. Unlike the MDA-MB-453 cell line, the activity of standard and isolated amygdalin was not observed at the concentrations lower than 400 μg cm-3 on MDA-MB-361 cell line. The isolated amygdalin has not shown the activity in other cell lines. The antiproliferative activity of amygdalin standard was also noticed on HeLa and LS-174 cell lines at the concentrations of 333.27 and 333.17 μg cm-3, respectively., Cilj ovog rada bila je procena biološke aktivnosti ekstrakta semena šljive i definisanje hemijskog sastava primenom ESI-MS metode. Tokom ispitivanja antioksidativne aktivnosti, ekstrakt je pokazao bolju sposobnost inhibiranja DPPH radikala u poređenju sa standardom amigdalina. Rezultati antimikrobne studije pokazali su da ekstrakt ima veći uticaj na rast Gram-negativnih bakterija u odnosnu na amigdalin. Gram-pozitivne bakterije i gljivice ostale su rezistentne u oba slučaja. Za razliku od amigdalina, ekstrakt je pokazao veću antimikrobnu aktivnost na iste sojeve mikroorganizama. Amigdalin je izolovan iz ekstrakta pre ispitivanja antiproliferativne aktivnosti na MDA-MB-361, MDA-MB-453, HeLa i LS174 ćelijskim linijama upotrebom MTT testa. Za razliku od MDA-MB-453 ćelijskih linija, aktivnost standarda i izolovanog amigdalina nije uočena na MDA-MB-361 ćelijskim linijama pri koncentracijama nižim od 400 μg cm-3. Izolovani amigdalin nije pokazao aktivnost na ostalim ćelijskim linijama. Antiproliferativna aktivnost standarda amigdalina uočena je i na HeLa i LS-174 ćelijskim linijama pri koncentracijama 333.27 i 333.17 μg cm-3, respektivno.", publisher = "Univerzitet u Nišu - Tehnološki fakultet, Leskovac", journal = "Advanced Technologies", title = "Chemical composition and biological activity of the plum seed extract, Hemijski sastav i biološka aktivnost ekstrakta semena šljive", volume = "5", number = "2", pages = "38-45", doi = "10.5937/savteh1602038S" }
Savić, I., Nikolić, V. D., Savić-Gajić, I., Kundaković, T., Stanojković, T.,& Najman, S. J.. (2016). Chemical composition and biological activity of the plum seed extract. in Advanced Technologies Univerzitet u Nišu - Tehnološki fakultet, Leskovac., 5(2), 38-45. https://doi.org/10.5937/savteh1602038S
Savić I, Nikolić VD, Savić-Gajić I, Kundaković T, Stanojković T, Najman SJ. Chemical composition and biological activity of the plum seed extract. in Advanced Technologies. 2016;5(2):38-45. doi:10.5937/savteh1602038S .
Savić, Ivan, Nikolić, Vesna D., Savić-Gajić, Ivana, Kundaković, Tatjana, Stanojković, Tatjana, Najman, Stevo J., "Chemical composition and biological activity of the plum seed extract" in Advanced Technologies, 5, no. 2 (2016):38-45, https://doi.org/10.5937/savteh1602038S . .