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Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative
dc.creator | Dobričić, Vladimir | |
dc.creator | Vladimirov, Sote | |
dc.creator | Čudina, Olivera | |
dc.date.accessioned | 2019-09-02T11:50:36Z | |
dc.date.available | 2019-09-02T11:50:36Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1450-9636 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2537 | |
dc.description.abstract | Cortienic acid was obtained by periodic acid oxidation of fluocinolone acetonide, whereas corresponding amide was synthesized from the cortienic acid and ethyl ester of b-alanine by dicyclohexylcarbodiimide - hydroxybenzotriazole coupling procedure. Lipophilicity of the amide was evaluated by using reversed-phase thin-layer chromatography systems, consisting of ethanol and water in various ratios, and was higher in comparison to fluocinolone acetonide and cortienic acid. | en |
dc.publisher | Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Kragujevac Journal of Science | |
dc.subject | cortienic acid | en |
dc.subject | amide | en |
dc.subject | lipophilicity | en |
dc.subject | RP-TLC | en |
dc.title | Synthesis and RP-TLC lipophilicity evaluation of a novel fluocinolon acetonide soft drug derivative | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Добричић, Владимир; Владимиров, Соте; Чудина, Оливера; | |
dc.citation.issue | 38 | |
dc.citation.spage | 107 | |
dc.citation.epage | 114 | |
dc.citation.other | (38): 107-114 | |
dc.citation.rank | M51 | |
dc.identifier.doi | 10.5937/KgJSci1638107D | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1211/2535.pdf | |
dc.type.version | publishedVersion |