Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies
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2016
Authors
Simić, MilenaPaunović, Nikola
Borić, Ivan
Ranđelović, Jelena
Vojnović, Sandra
Nikodinović-Runić, Jasmina
Pekmezović, Marina
Savić, Vladimir
Article (Published version)
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A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.
Source:
Bioorganic & Medicinal Chemistry Letters, 2016, 26, 1, 235-239Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Computational design, synthesis and biological evaluation of new heterocyclic compounds as selective tumorogenesis inhibitors (RS-MESTD-Basic Research (BR or ON)-172009)
DOI: 10.1016/j.bmcl.2015.08.086
ISSN: 0960-894X
PubMed: 26586600
WoS: 000366161600044
Scopus: 2-s2.0-84949570559
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PharmacyTY - JOUR AU - Simić, Milena AU - Paunović, Nikola AU - Borić, Ivan AU - Ranđelović, Jelena AU - Vojnović, Sandra AU - Nikodinović-Runić, Jasmina AU - Pekmezović, Marina AU - Savić, Vladimir PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2580 AB - A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Bioorganic & Medicinal Chemistry Letters T1 - Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies VL - 26 IS - 1 SP - 235 EP - 239 DO - 10.1016/j.bmcl.2015.08.086 ER -
@article{ author = "Simić, Milena and Paunović, Nikola and Borić, Ivan and Ranđelović, Jelena and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Pekmezović, Marina and Savić, Vladimir", year = "2016", abstract = "A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Bioorganic & Medicinal Chemistry Letters", title = "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies", volume = "26", number = "1", pages = "235-239", doi = "10.1016/j.bmcl.2015.08.086" }
Simić, M., Paunović, N., Borić, I., Ranđelović, J., Vojnović, S., Nikodinović-Runić, J., Pekmezović, M.,& Savić, V.. (2016). Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic & Medicinal Chemistry Letters Pergamon-Elsevier Science Ltd, Oxford., 26(1), 235-239. https://doi.org/10.1016/j.bmcl.2015.08.086
Simić M, Paunović N, Borić I, Ranđelović J, Vojnović S, Nikodinović-Runić J, Pekmezović M, Savić V. Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic & Medicinal Chemistry Letters. 2016;26(1):235-239. doi:10.1016/j.bmcl.2015.08.086 .
Simić, Milena, Paunović, Nikola, Borić, Ivan, Ranđelović, Jelena, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Pekmezović, Marina, Savić, Vladimir, "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies" in Bioorganic & Medicinal Chemistry Letters, 26, no. 1 (2016):235-239, https://doi.org/10.1016/j.bmcl.2015.08.086 . .