Synthesis, cytotoxicity and computational study of novel protoberberine derivatives
2016
Autori
Simić, MilenaDamjanović, Ana B.
Kalinić, Marko
Tasić, Gordana
Erić, Slavica
Antić-Stanković, Jelena
Savić, Vladimir
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A novel and efficient synthetic route was developed for the preparation of protoberberine derivatives. A methodology, designed primarily to control the substitution patterns on the terminal rings, was used to access a small array of these compounds. An initial biological profiling suggested an anticancer potential of the synthesised derivatives, while structure-based target fishing identified their potential targets and established a rational basis for further structural modifications. Although the activities need further improvement, the study demonstrated that the described approach may be useful in the discovery of novel lead compounds.
Izvor:
Journal of the Serbian Chemical Society, 2016, 81, 2, 103-123Izdavač:
- Srpsko hemijsko društvo, Beograd
Finansiranje / projekti:
- Kompjutersko dizajniranje, sinteza i biološka evaluacija novih heterocikličnih jedinjenja kao selektivnih inhibitora tumorogeneze (RS-MESTD-Basic Research (BR or ON)-172009)
DOI: 10.2298/JSC150525090S
ISSN: 0352-5139
WoS: 000372079900001
Scopus: 2-s2.0-84963616111
Institucija/grupa
PharmacyTY - JOUR AU - Simić, Milena AU - Damjanović, Ana B. AU - Kalinić, Marko AU - Tasić, Gordana AU - Erić, Slavica AU - Antić-Stanković, Jelena AU - Savić, Vladimir PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2606 AB - A novel and efficient synthetic route was developed for the preparation of protoberberine derivatives. A methodology, designed primarily to control the substitution patterns on the terminal rings, was used to access a small array of these compounds. An initial biological profiling suggested an anticancer potential of the synthesised derivatives, while structure-based target fishing identified their potential targets and established a rational basis for further structural modifications. Although the activities need further improvement, the study demonstrated that the described approach may be useful in the discovery of novel lead compounds. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Synthesis, cytotoxicity and computational study of novel protoberberine derivatives VL - 81 IS - 2 SP - 103 EP - 123 DO - 10.2298/JSC150525090S ER -
@article{ author = "Simić, Milena and Damjanović, Ana B. and Kalinić, Marko and Tasić, Gordana and Erić, Slavica and Antić-Stanković, Jelena and Savić, Vladimir", year = "2016", abstract = "A novel and efficient synthetic route was developed for the preparation of protoberberine derivatives. A methodology, designed primarily to control the substitution patterns on the terminal rings, was used to access a small array of these compounds. An initial biological profiling suggested an anticancer potential of the synthesised derivatives, while structure-based target fishing identified their potential targets and established a rational basis for further structural modifications. Although the activities need further improvement, the study demonstrated that the described approach may be useful in the discovery of novel lead compounds.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Synthesis, cytotoxicity and computational study of novel protoberberine derivatives", volume = "81", number = "2", pages = "103-123", doi = "10.2298/JSC150525090S" }
Simić, M., Damjanović, A. B., Kalinić, M., Tasić, G., Erić, S., Antić-Stanković, J.,& Savić, V.. (2016). Synthesis, cytotoxicity and computational study of novel protoberberine derivatives. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 81(2), 103-123. https://doi.org/10.2298/JSC150525090S
Simić M, Damjanović AB, Kalinić M, Tasić G, Erić S, Antić-Stanković J, Savić V. Synthesis, cytotoxicity and computational study of novel protoberberine derivatives. in Journal of the Serbian Chemical Society. 2016;81(2):103-123. doi:10.2298/JSC150525090S .
Simić, Milena, Damjanović, Ana B., Kalinić, Marko, Tasić, Gordana, Erić, Slavica, Antić-Stanković, Jelena, Savić, Vladimir, "Synthesis, cytotoxicity and computational study of novel protoberberine derivatives" in Journal of the Serbian Chemical Society, 81, no. 2 (2016):103-123, https://doi.org/10.2298/JSC150525090S . .