Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine
Spektrofotometrijsko određivanje fluokortolona u tabletama sa reagensom 1,4-dihidrazinoftalazinom
Abstract
The proposed method for the determination of fluocortolone is based on the formation of a stable, yellow coloured hydrazone product with 1,4-dihydrazinophthalazine as the reagent. Heating at 85 °C for 2 h was found to be necessary to ensure optimal hydrazone formation in acidified 1-propanol as the solvent. The detection limit was 1.2 μg/ml. This method when applied for the determination of fluocortolone in pharmaceutical formulations gave precise and reproducible results.
Predložena spektrofotometrijska metoda određivanja fluokortolona se zasniva na građenju žuto obojenog proizvoda tipa hidrazona sa 1,4-dihidrazinoftalazinom kao reagensom. Metoda je reproduktivna kada se reakcija izvodi iz 1-propanola kome je dodata koncentrovana kiselina, uz zagrevanje na 85 °C u toku 2 sata. Limit detekcije iznosi 1,2 μg/ml. Predložena spektrofotometrijska metoda je primenjena za određivanje sadržaja fluokortolona u farmaceutskim oblicima.
Keywords:
fluocortolone / 1, 4-dihydrazinophthalazine / tablets / spectrophotometrySource:
Journal of the Serbian Chemical Society, 2000, 65, 9, 645-648Publisher:
- Srpsko hemijsko društvo, Beograd
Collections
Institution/Community
PharmacyTY - JOUR AU - Čudina, Olivera AU - Vladimirov, Sote AU - Živanov-Stakić, Dobrila AU - Agbaba, Danica PY - 2000 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/264 AB - The proposed method for the determination of fluocortolone is based on the formation of a stable, yellow coloured hydrazone product with 1,4-dihydrazinophthalazine as the reagent. Heating at 85 °C for 2 h was found to be necessary to ensure optimal hydrazone formation in acidified 1-propanol as the solvent. The detection limit was 1.2 μg/ml. This method when applied for the determination of fluocortolone in pharmaceutical formulations gave precise and reproducible results. AB - Predložena spektrofotometrijska metoda određivanja fluokortolona se zasniva na građenju žuto obojenog proizvoda tipa hidrazona sa 1,4-dihidrazinoftalazinom kao reagensom. Metoda je reproduktivna kada se reakcija izvodi iz 1-propanola kome je dodata koncentrovana kiselina, uz zagrevanje na 85 °C u toku 2 sata. Limit detekcije iznosi 1,2 μg/ml. Predložena spektrofotometrijska metoda je primenjena za određivanje sadržaja fluokortolona u farmaceutskim oblicima. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine T1 - Spektrofotometrijsko određivanje fluokortolona u tabletama sa reagensom 1,4-dihidrazinoftalazinom VL - 65 IS - 9 SP - 645 EP - 648 UR - https://hdl.handle.net/21.15107/rcub_farfar_264 ER -
@article{ author = "Čudina, Olivera and Vladimirov, Sote and Živanov-Stakić, Dobrila and Agbaba, Danica", year = "2000", abstract = "The proposed method for the determination of fluocortolone is based on the formation of a stable, yellow coloured hydrazone product with 1,4-dihydrazinophthalazine as the reagent. Heating at 85 °C for 2 h was found to be necessary to ensure optimal hydrazone formation in acidified 1-propanol as the solvent. The detection limit was 1.2 μg/ml. This method when applied for the determination of fluocortolone in pharmaceutical formulations gave precise and reproducible results., Predložena spektrofotometrijska metoda određivanja fluokortolona se zasniva na građenju žuto obojenog proizvoda tipa hidrazona sa 1,4-dihidrazinoftalazinom kao reagensom. Metoda je reproduktivna kada se reakcija izvodi iz 1-propanola kome je dodata koncentrovana kiselina, uz zagrevanje na 85 °C u toku 2 sata. Limit detekcije iznosi 1,2 μg/ml. Predložena spektrofotometrijska metoda je primenjena za određivanje sadržaja fluokortolona u farmaceutskim oblicima.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine, Spektrofotometrijsko određivanje fluokortolona u tabletama sa reagensom 1,4-dihidrazinoftalazinom", volume = "65", number = "9", pages = "645-648", url = "https://hdl.handle.net/21.15107/rcub_farfar_264" }
Čudina, O., Vladimirov, S., Živanov-Stakić, D.,& Agbaba, D.. (2000). Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 65(9), 645-648. https://hdl.handle.net/21.15107/rcub_farfar_264
Čudina O, Vladimirov S, Živanov-Stakić D, Agbaba D. Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine. in Journal of the Serbian Chemical Society. 2000;65(9):645-648. https://hdl.handle.net/21.15107/rcub_farfar_264 .
Čudina, Olivera, Vladimirov, Sote, Živanov-Stakić, Dobrila, Agbaba, Danica, "Spectrophotometric determination of fluocortolone in tablets using 1,4-dihydrazinophthalazine" in Journal of the Serbian Chemical Society, 65, no. 9 (2000):645-648, https://hdl.handle.net/21.15107/rcub_farfar_264 .