Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients
Само за регистроване кориснике
2016
Аутори
Stanisavljević, NatašaStojanović, Ljudmila
Marisavljević, D.
Đoković, A.
Dopsaj, Violeta
Kotur-Stevuljević, Jelena
Martinović, Jelena
Memon, Lidija
Radovanović, Slavica
Todić, B.
Lisulov, D.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to evaluate oxidative stress markers and it relations to endothelial damage as risk factor for thrombosis in patients with primary (PAPS) and secondary (SAPS) antiphospholipid syndrome (APS) in correlation to traditional risk factors. Flow-mediated (FMD) and nitroglycerine (NMD)-induced dilation of the brachial artery were studied in 140 APS patients (90 PAPS, 50 SAPS) and 40 controls matched by age, sex, and conventional risk factors for atherosclerosis. Markers of oxidative stress, lipid hydroperoxydes (LOOH), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG), and paraoxonase 1 activity (PON1) were determined by spectrophotometric method. Oxidative stress dominates in APS patients. LOOH and AOPP correlate to lipid fractions (p lt 0.05), unlike PON1, tSHG that correlated to antiphospholipid antibody positivity (p lt 0.05). FMD was lower in APS patients comparing to controls (p lt 0.001). Cholesterol is independent variable for F...MD impairment in control group (p = 0.011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively). Combined predictive of aCL and LOOH is better for FMD impairment than LOOH alone in both PAPS and SAPS patients (AUC 0.727, p = 0.001, 95 % CI 0.616-0.837 and AUC 0.824, pE,0.001, 95 % CI 0.690-0.957, respectively). Lipid peroxidation is independent predictor for endothelial dysfunction in APS patients. We demonstrated synergistic effect of aCL and LOOH as risk for endothelial impairment in both PAPS and SAPS patients.
Извор:
Clinical Rheumatology, 2016, 35, 10, 2485-2493Издавач:
- Springer London Ltd, London
Финансирање / пројекти:
- Ministry of Science of the Republic of Serbia - 175
DOI: 10.1007/s10067-016-3369-8
ISSN: 0770-3198
PubMed: 27562033
WoS: 000385142900014
Scopus: 2-s2.0-84983419335
Институција/група
PharmacyTY - JOUR AU - Stanisavljević, Nataša AU - Stojanović, Ljudmila AU - Marisavljević, D. AU - Đoković, A. AU - Dopsaj, Violeta AU - Kotur-Stevuljević, Jelena AU - Martinović, Jelena AU - Memon, Lidija AU - Radovanović, Slavica AU - Todić, B. AU - Lisulov, D. PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2710 AB - The aim of this study was to evaluate oxidative stress markers and it relations to endothelial damage as risk factor for thrombosis in patients with primary (PAPS) and secondary (SAPS) antiphospholipid syndrome (APS) in correlation to traditional risk factors. Flow-mediated (FMD) and nitroglycerine (NMD)-induced dilation of the brachial artery were studied in 140 APS patients (90 PAPS, 50 SAPS) and 40 controls matched by age, sex, and conventional risk factors for atherosclerosis. Markers of oxidative stress, lipid hydroperoxydes (LOOH), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG), and paraoxonase 1 activity (PON1) were determined by spectrophotometric method. Oxidative stress dominates in APS patients. LOOH and AOPP correlate to lipid fractions (p lt 0.05), unlike PON1, tSHG that correlated to antiphospholipid antibody positivity (p lt 0.05). FMD was lower in APS patients comparing to controls (p lt 0.001). Cholesterol is independent variable for FMD impairment in control group (p = 0.011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively). Combined predictive of aCL and LOOH is better for FMD impairment than LOOH alone in both PAPS and SAPS patients (AUC 0.727, p = 0.001, 95 % CI 0.616-0.837 and AUC 0.824, pE,0.001, 95 % CI 0.690-0.957, respectively). Lipid peroxidation is independent predictor for endothelial dysfunction in APS patients. We demonstrated synergistic effect of aCL and LOOH as risk for endothelial impairment in both PAPS and SAPS patients. PB - Springer London Ltd, London T2 - Clinical Rheumatology T1 - Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients VL - 35 IS - 10 SP - 2485 EP - 2493 DO - 10.1007/s10067-016-3369-8 ER -
@article{ author = "Stanisavljević, Nataša and Stojanović, Ljudmila and Marisavljević, D. and Đoković, A. and Dopsaj, Violeta and Kotur-Stevuljević, Jelena and Martinović, Jelena and Memon, Lidija and Radovanović, Slavica and Todić, B. and Lisulov, D.", year = "2016", abstract = "The aim of this study was to evaluate oxidative stress markers and it relations to endothelial damage as risk factor for thrombosis in patients with primary (PAPS) and secondary (SAPS) antiphospholipid syndrome (APS) in correlation to traditional risk factors. Flow-mediated (FMD) and nitroglycerine (NMD)-induced dilation of the brachial artery were studied in 140 APS patients (90 PAPS, 50 SAPS) and 40 controls matched by age, sex, and conventional risk factors for atherosclerosis. Markers of oxidative stress, lipid hydroperoxydes (LOOH), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG), and paraoxonase 1 activity (PON1) were determined by spectrophotometric method. Oxidative stress dominates in APS patients. LOOH and AOPP correlate to lipid fractions (p lt 0.05), unlike PON1, tSHG that correlated to antiphospholipid antibody positivity (p lt 0.05). FMD was lower in APS patients comparing to controls (p lt 0.001). Cholesterol is independent variable for FMD impairment in control group (p = 0.011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively). Combined predictive of aCL and LOOH is better for FMD impairment than LOOH alone in both PAPS and SAPS patients (AUC 0.727, p = 0.001, 95 % CI 0.616-0.837 and AUC 0.824, pE,0.001, 95 % CI 0.690-0.957, respectively). Lipid peroxidation is independent predictor for endothelial dysfunction in APS patients. We demonstrated synergistic effect of aCL and LOOH as risk for endothelial impairment in both PAPS and SAPS patients.", publisher = "Springer London Ltd, London", journal = "Clinical Rheumatology", title = "Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients", volume = "35", number = "10", pages = "2485-2493", doi = "10.1007/s10067-016-3369-8" }
Stanisavljević, N., Stojanović, L., Marisavljević, D., Đoković, A., Dopsaj, V., Kotur-Stevuljević, J., Martinović, J., Memon, L., Radovanović, S., Todić, B.,& Lisulov, D.. (2016). Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients. in Clinical Rheumatology Springer London Ltd, London., 35(10), 2485-2493. https://doi.org/10.1007/s10067-016-3369-8
Stanisavljević N, Stojanović L, Marisavljević D, Đoković A, Dopsaj V, Kotur-Stevuljević J, Martinović J, Memon L, Radovanović S, Todić B, Lisulov D. Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients. in Clinical Rheumatology. 2016;35(10):2485-2493. doi:10.1007/s10067-016-3369-8 .
Stanisavljević, Nataša, Stojanović, Ljudmila, Marisavljević, D., Đoković, A., Dopsaj, Violeta, Kotur-Stevuljević, Jelena, Martinović, Jelena, Memon, Lidija, Radovanović, Slavica, Todić, B., Lisulov, D., "Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients" in Clinical Rheumatology, 35, no. 10 (2016):2485-2493, https://doi.org/10.1007/s10067-016-3369-8 . .