Zinc complex-based determination of rutin in dietary supplements
2016
Аутори
Pavun, LeposavaJelikić-Stankov, Milena
Đurđević, Predrag
Ćirić, Andrija
Uskoković-Marković, Snežana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to develop and validate a simple, rapid, sensitive and low-cost method for determination of rutin in tablets. The proposed spectrophotometric method is based on the formation of the Zn2+-rutin complex in methanol 70% (v/v) at pH 8.52, and detection at lambda(max)= 410 nm. The concentration range over which the response was linear was 0.3-12.2 mu g ml(-1). The limit of detection (LOD) and the limit of quantification (LOQ) were 0.21 mu g ml(-1) and 0.63 mu g ml(-1), respectively. The proposed method was successfully applied to the determination of rutin in herbal dietary supplements. The reliability of the method was checked by comparison with results obtained by the established RP-HPLC/UV method. The proposed method fulfills all aimed requirements.
Извор:
Macedonian Journal of Chemistry and Chemical Engineering, 2016, 35, 1, 13-18Издавач:
- Soc Chemists Technologists Madeconia, Skopje
Финансирање / пројекти:
- Синтеза, моделовање, физичко-хемијске и биолошке особине органских једињења и одговарајућих комплекса метала (RS-MESTD-Basic Research (BR or ON)-172016)
DOI: 10.20450/mjcce.2016.897
ISSN: 1857-5552
WoS: 000379376400002
Scopus: 2-s2.0-84981161237
Институција/група
PharmacyTY - JOUR AU - Pavun, Leposava AU - Jelikić-Stankov, Milena AU - Đurđević, Predrag AU - Ćirić, Andrija AU - Uskoković-Marković, Snežana PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2751 AB - The aim of this study was to develop and validate a simple, rapid, sensitive and low-cost method for determination of rutin in tablets. The proposed spectrophotometric method is based on the formation of the Zn2+-rutin complex in methanol 70% (v/v) at pH 8.52, and detection at lambda(max)= 410 nm. The concentration range over which the response was linear was 0.3-12.2 mu g ml(-1). The limit of detection (LOD) and the limit of quantification (LOQ) were 0.21 mu g ml(-1) and 0.63 mu g ml(-1), respectively. The proposed method was successfully applied to the determination of rutin in herbal dietary supplements. The reliability of the method was checked by comparison with results obtained by the established RP-HPLC/UV method. The proposed method fulfills all aimed requirements. PB - Soc Chemists Technologists Madeconia, Skopje T2 - Macedonian Journal of Chemistry and Chemical Engineering T1 - Zinc complex-based determination of rutin in dietary supplements VL - 35 IS - 1 SP - 13 EP - 18 DO - 10.20450/mjcce.2016.897 ER -
@article{ author = "Pavun, Leposava and Jelikić-Stankov, Milena and Đurđević, Predrag and Ćirić, Andrija and Uskoković-Marković, Snežana", year = "2016", abstract = "The aim of this study was to develop and validate a simple, rapid, sensitive and low-cost method for determination of rutin in tablets. The proposed spectrophotometric method is based on the formation of the Zn2+-rutin complex in methanol 70% (v/v) at pH 8.52, and detection at lambda(max)= 410 nm. The concentration range over which the response was linear was 0.3-12.2 mu g ml(-1). The limit of detection (LOD) and the limit of quantification (LOQ) were 0.21 mu g ml(-1) and 0.63 mu g ml(-1), respectively. The proposed method was successfully applied to the determination of rutin in herbal dietary supplements. The reliability of the method was checked by comparison with results obtained by the established RP-HPLC/UV method. The proposed method fulfills all aimed requirements.", publisher = "Soc Chemists Technologists Madeconia, Skopje", journal = "Macedonian Journal of Chemistry and Chemical Engineering", title = "Zinc complex-based determination of rutin in dietary supplements", volume = "35", number = "1", pages = "13-18", doi = "10.20450/mjcce.2016.897" }
Pavun, L., Jelikić-Stankov, M., Đurđević, P., Ćirić, A.,& Uskoković-Marković, S.. (2016). Zinc complex-based determination of rutin in dietary supplements. in Macedonian Journal of Chemistry and Chemical Engineering Soc Chemists Technologists Madeconia, Skopje., 35(1), 13-18. https://doi.org/10.20450/mjcce.2016.897
Pavun L, Jelikić-Stankov M, Đurđević P, Ćirić A, Uskoković-Marković S. Zinc complex-based determination of rutin in dietary supplements. in Macedonian Journal of Chemistry and Chemical Engineering. 2016;35(1):13-18. doi:10.20450/mjcce.2016.897 .
Pavun, Leposava, Jelikić-Stankov, Milena, Đurđević, Predrag, Ćirić, Andrija, Uskoković-Marković, Snežana, "Zinc complex-based determination of rutin in dietary supplements" in Macedonian Journal of Chemistry and Chemical Engineering, 35, no. 1 (2016):13-18, https://doi.org/10.20450/mjcce.2016.897 . .