Evaluation of drug-related problems in older polypharmacy primary care patients
Само за регистроване кориснике
2017
Аутори
Vezmar-Kovačević, SandraMiljković, Branislava
Ćulafić, Milica
Kovačević, Milena
Golubović, Bojana
Jovanović, Marija
Vučićević, Katarina
de Gier, Johan J.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Aims and Objectives Targeting older patients with predictive factors for drug-related problems (DRPs) could make clinical medication reviews more cost-effective. The aim of this study was to identify the number, type, and potential predictive factors for DRPs in older polypharmacy patients. Methods Community pharmacists performed clinical medication reviews and documented DRPs, types of interventions, and their implementation in older patients. Results Three hundred eighty-eight medication reviews were analyzed, 964 DRPs (average 2.51.9), and 1022 interventions (average 2.6 +/- 2.0) were identified. The overall implementation rate of interventions was 70.1%, the highest was observed in interventions aiming to resolve the lack of therapy monitoring (86.8%). Patients with 12 medications had an increased risk of 5 DRPs (P lt .001). Asthma was associated with lack of adherence (P = .002), lack of aspirin, statins, and proton pump inhibitors use with additional therapy needed (P = .002-.0...04). Predictive factors for drug interactions were antihypertensive medications and/or medications with narrow therapeutic index (P lt .05). Lack of efficacy was associated with diabetes (P = .006). Nonsteroidal anti-inflammatory drugs were risk factors for inappropriate drug selection (P = .002). Lack of monitoring was associated with hypertension (P = .013), whereas benzodiazepines (P lt .001) and aspirin (P = .021) were overused. Conclusion Patients with asthma, hypertension, and diabetes and lack of statin, antithrombotic agent, and/or proton pump inhibitor use were associated with higher risks for DRPs.
Кључне речи:
clinical medication review / community pharmacy / drug-related problems / older patients / polypharmacyИзвор:
Journal of Evaluation in Clinical Practice, 2017, 23, 4, 860-865Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Базична и клиничко-фармаколошка истраживања механизама дејства и интеракција лекова у нервном и кардиоваскуларном систему (RS-MESTD-Basic Research (BR or ON)-175023)
DOI: 10.1111/jep.12737
ISSN: 1356-1294
PubMed: 28370742
WoS: 000406299200024
Scopus: 2-s2.0-85016600235
Институција/група
PharmacyTY - JOUR AU - Vezmar-Kovačević, Sandra AU - Miljković, Branislava AU - Ćulafić, Milica AU - Kovačević, Milena AU - Golubović, Bojana AU - Jovanović, Marija AU - Vučićević, Katarina AU - de Gier, Johan J. PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2811 AB - Aims and Objectives Targeting older patients with predictive factors for drug-related problems (DRPs) could make clinical medication reviews more cost-effective. The aim of this study was to identify the number, type, and potential predictive factors for DRPs in older polypharmacy patients. Methods Community pharmacists performed clinical medication reviews and documented DRPs, types of interventions, and their implementation in older patients. Results Three hundred eighty-eight medication reviews were analyzed, 964 DRPs (average 2.51.9), and 1022 interventions (average 2.6 +/- 2.0) were identified. The overall implementation rate of interventions was 70.1%, the highest was observed in interventions aiming to resolve the lack of therapy monitoring (86.8%). Patients with 12 medications had an increased risk of 5 DRPs (P lt .001). Asthma was associated with lack of adherence (P = .002), lack of aspirin, statins, and proton pump inhibitors use with additional therapy needed (P = .002-.004). Predictive factors for drug interactions were antihypertensive medications and/or medications with narrow therapeutic index (P lt .05). Lack of efficacy was associated with diabetes (P = .006). Nonsteroidal anti-inflammatory drugs were risk factors for inappropriate drug selection (P = .002). Lack of monitoring was associated with hypertension (P = .013), whereas benzodiazepines (P lt .001) and aspirin (P = .021) were overused. Conclusion Patients with asthma, hypertension, and diabetes and lack of statin, antithrombotic agent, and/or proton pump inhibitor use were associated with higher risks for DRPs. PB - Wiley, Hoboken T2 - Journal of Evaluation in Clinical Practice T1 - Evaluation of drug-related problems in older polypharmacy primary care patients VL - 23 IS - 4 SP - 860 EP - 865 DO - 10.1111/jep.12737 ER -
@article{ author = "Vezmar-Kovačević, Sandra and Miljković, Branislava and Ćulafić, Milica and Kovačević, Milena and Golubović, Bojana and Jovanović, Marija and Vučićević, Katarina and de Gier, Johan J.", year = "2017", abstract = "Aims and Objectives Targeting older patients with predictive factors for drug-related problems (DRPs) could make clinical medication reviews more cost-effective. The aim of this study was to identify the number, type, and potential predictive factors for DRPs in older polypharmacy patients. Methods Community pharmacists performed clinical medication reviews and documented DRPs, types of interventions, and their implementation in older patients. Results Three hundred eighty-eight medication reviews were analyzed, 964 DRPs (average 2.51.9), and 1022 interventions (average 2.6 +/- 2.0) were identified. The overall implementation rate of interventions was 70.1%, the highest was observed in interventions aiming to resolve the lack of therapy monitoring (86.8%). Patients with 12 medications had an increased risk of 5 DRPs (P lt .001). Asthma was associated with lack of adherence (P = .002), lack of aspirin, statins, and proton pump inhibitors use with additional therapy needed (P = .002-.004). Predictive factors for drug interactions were antihypertensive medications and/or medications with narrow therapeutic index (P lt .05). Lack of efficacy was associated with diabetes (P = .006). Nonsteroidal anti-inflammatory drugs were risk factors for inappropriate drug selection (P = .002). Lack of monitoring was associated with hypertension (P = .013), whereas benzodiazepines (P lt .001) and aspirin (P = .021) were overused. Conclusion Patients with asthma, hypertension, and diabetes and lack of statin, antithrombotic agent, and/or proton pump inhibitor use were associated with higher risks for DRPs.", publisher = "Wiley, Hoboken", journal = "Journal of Evaluation in Clinical Practice", title = "Evaluation of drug-related problems in older polypharmacy primary care patients", volume = "23", number = "4", pages = "860-865", doi = "10.1111/jep.12737" }
Vezmar-Kovačević, S., Miljković, B., Ćulafić, M., Kovačević, M., Golubović, B., Jovanović, M., Vučićević, K.,& de Gier, J. J.. (2017). Evaluation of drug-related problems in older polypharmacy primary care patients. in Journal of Evaluation in Clinical Practice Wiley, Hoboken., 23(4), 860-865. https://doi.org/10.1111/jep.12737
Vezmar-Kovačević S, Miljković B, Ćulafić M, Kovačević M, Golubović B, Jovanović M, Vučićević K, de Gier JJ. Evaluation of drug-related problems in older polypharmacy primary care patients. in Journal of Evaluation in Clinical Practice. 2017;23(4):860-865. doi:10.1111/jep.12737 .
Vezmar-Kovačević, Sandra, Miljković, Branislava, Ćulafić, Milica, Kovačević, Milena, Golubović, Bojana, Jovanović, Marija, Vučićević, Katarina, de Gier, Johan J., "Evaluation of drug-related problems in older polypharmacy primary care patients" in Journal of Evaluation in Clinical Practice, 23, no. 4 (2017):860-865, https://doi.org/10.1111/jep.12737 . .