Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients
2017
Authors
Miljković, MilicaStefanović, Aleksandra
Bogavac-Stanojević, Nataša
Simić-Ogrizović, Sanja
Dumić, Jerka
Cerne, Darko
Jelić-Ivanović, Zorana
Kotur-Stevuljević, Jelena
Article (Published version)
Metadata
Show full item recordAbstract
Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p lt 0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p lt 0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p lt 0.01 and p lt 0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients w...ith high and low risk of a coronary event.
Keywords:
Kidney diseases / Pentraxin-3 / Galectin-3 / Matrix-metalloproteinase-9 / Tissue inhibitor of matrix metalloproteinase-1 / Risk factors / Risk assessment / Cardiovascular diseasesSource:
Acta Clinica Croatica, 2017, 56, 4, 673-680Publisher:
- Sestre Milosrdnice Univ Hospital, Zagreb
Funding / projects:
- Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.20471/acc.2017.56.04.14
ISSN: 0353-9466
PubMed: 29590722
WoS: 000426891900014
Scopus: 2-s2.0-85042388871
Collections
Institution/Community
PharmacyTY - JOUR AU - Miljković, Milica AU - Stefanović, Aleksandra AU - Bogavac-Stanojević, Nataša AU - Simić-Ogrizović, Sanja AU - Dumić, Jerka AU - Cerne, Darko AU - Jelić-Ivanović, Zorana AU - Kotur-Stevuljević, Jelena PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2886 AB - Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p lt 0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p lt 0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p lt 0.01 and p lt 0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event. PB - Sestre Milosrdnice Univ Hospital, Zagreb T2 - Acta Clinica Croatica T1 - Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients VL - 56 IS - 4 SP - 673 EP - 680 DO - 10.20471/acc.2017.56.04.14 ER -
@article{ author = "Miljković, Milica and Stefanović, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Dumić, Jerka and Cerne, Darko and Jelić-Ivanović, Zorana and Kotur-Stevuljević, Jelena", year = "2017", abstract = "Inflammation, apoptosis and extracellular remodeling play significant roles in cardiovascular disease (CVD) underlying the major causes of mortality in renal patients. In 19 pre-dialysis patients, 21 dialysis patients and 20 control subjects, the concentrations of pentraxin-3, galectin-3, MMP-9 and TIMP-1 were determined by ELISA. CVD risk was calculated according to the Framingham risk score algorithm. Pentraxin-3 was increased in renal patients compared to healthy controls (p lt 0.001). In contrast, galectin-3 was reduced in hemodialysis patients compared to pre-dialysis patients and controls (p lt 0.001). In addition, MMP-9 and TIMP-1 were elevated in renal patients compared to controls (p lt 0.01 and p lt 0.001, respectively). Logistic regression analyses disclosed associations of galectin-3, MMP-9, pentraxin-3 and glomerular filtration with calculated CVD risk score. Combined testing of pentraxin-3, galectin-3, MMP-9 and glomerular filtration rate can discriminate renal patients with high and low risk of a coronary event.", publisher = "Sestre Milosrdnice Univ Hospital, Zagreb", journal = "Acta Clinica Croatica", title = "Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients", volume = "56", number = "4", pages = "673-680", doi = "10.20471/acc.2017.56.04.14" }
Miljković, M., Stefanović, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Dumić, J., Cerne, D., Jelić-Ivanović, Z.,& Kotur-Stevuljević, J.. (2017). Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients. in Acta Clinica Croatica Sestre Milosrdnice Univ Hospital, Zagreb., 56(4), 673-680. https://doi.org/10.20471/acc.2017.56.04.14
Miljković M, Stefanović A, Bogavac-Stanojević N, Simić-Ogrizović S, Dumić J, Cerne D, Jelić-Ivanović Z, Kotur-Stevuljević J. Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients. in Acta Clinica Croatica. 2017;56(4):673-680. doi:10.20471/acc.2017.56.04.14 .
Miljković, Milica, Stefanović, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Dumić, Jerka, Cerne, Darko, Jelić-Ivanović, Zorana, Kotur-Stevuljević, Jelena, "Association of pentraxin-3, galectin-3 and matrix metalloproteinase-9/TIMP-1 with cardiovascular risk in renal disease patients" in Acta Clinica Croatica, 56, no. 4 (2017):673-680, https://doi.org/10.20471/acc.2017.56.04.14 . .