Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study
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2017
Authors
Radojcić, Maja R.El Marroun, Hanan
Miljković, Branislava
Stricker, Bruno H. C.
Jaddoe, Vincent W. V.
Verhulst, Frank C.
White, Tonya
Tiemeier, Henning
Article (Published version)
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Benzodiazepines and benzodiazepine-related medications (BBRMs) are anxiolytics and hypnotics acting on amino butyric acid (GABA)A receptors. BBRMs are assumed to have a low potential for major congenital malformations, but research on more subtle and protracted developing symptoms of these medications is lacking. Therefore, we prospectively investigated the association between BBRM use in pregnancy and long-term effects on child behavior in a large population-based cohort study. The study population consisted of 104 children prenatally exposed to BBRM, 527 children exposed to maternal prenatal anxiety or phobic anxiety symptoms (without exposure to BBRM), and 5609 control children. At child age, 6 years, Oppositional Defiant Disorder (ODD), Aggressive Behavior and Anxiety Problems were assessed by the Child Behavior Checklist (CBCL) reported by the mother and the Teacher Report Form (TRF). Children prenatally exposed to BBRM had higher scores of ODD and aggressive behavior, but not of ...anxiety. However, these associations were explained by maternal anxiety symptoms during pregnancy. Moreover, prenatal exposure to anxiety (without exposure to BBRM) was associated with increased scores of child ODD, aggressive behavior, and anxiety. In conclusion, the current study demonstrates that prenatal BBRM exposure was not independently associated with ODD and aggressive behavior in childhood when prenatal anxiety symptoms were taken into account.
Source:
Neurotoxicology and Teratology, 2017, 61, 58-65Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Erasmus Mundus-Western Balkans grant (ERAWEB) - 2011-2586/001-001-EMA2
- Erasmus Medical Center
DOI: 10.1016/j.ntt.2017.02.005
ISSN: 0892-0362
PubMed: 28259732
WoS: 000403512700007
Scopus: 2-s2.0-85014624193
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PharmacyTY - JOUR AU - Radojcić, Maja R. AU - El Marroun, Hanan AU - Miljković, Branislava AU - Stricker, Bruno H. C. AU - Jaddoe, Vincent W. V. AU - Verhulst, Frank C. AU - White, Tonya AU - Tiemeier, Henning PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2982 AB - Benzodiazepines and benzodiazepine-related medications (BBRMs) are anxiolytics and hypnotics acting on amino butyric acid (GABA)A receptors. BBRMs are assumed to have a low potential for major congenital malformations, but research on more subtle and protracted developing symptoms of these medications is lacking. Therefore, we prospectively investigated the association between BBRM use in pregnancy and long-term effects on child behavior in a large population-based cohort study. The study population consisted of 104 children prenatally exposed to BBRM, 527 children exposed to maternal prenatal anxiety or phobic anxiety symptoms (without exposure to BBRM), and 5609 control children. At child age, 6 years, Oppositional Defiant Disorder (ODD), Aggressive Behavior and Anxiety Problems were assessed by the Child Behavior Checklist (CBCL) reported by the mother and the Teacher Report Form (TRF). Children prenatally exposed to BBRM had higher scores of ODD and aggressive behavior, but not of anxiety. However, these associations were explained by maternal anxiety symptoms during pregnancy. Moreover, prenatal exposure to anxiety (without exposure to BBRM) was associated with increased scores of child ODD, aggressive behavior, and anxiety. In conclusion, the current study demonstrates that prenatal BBRM exposure was not independently associated with ODD and aggressive behavior in childhood when prenatal anxiety symptoms were taken into account. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Neurotoxicology and Teratology T1 - Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study VL - 61 SP - 58 EP - 65 DO - 10.1016/j.ntt.2017.02.005 ER -
@article{ author = "Radojcić, Maja R. and El Marroun, Hanan and Miljković, Branislava and Stricker, Bruno H. C. and Jaddoe, Vincent W. V. and Verhulst, Frank C. and White, Tonya and Tiemeier, Henning", year = "2017", abstract = "Benzodiazepines and benzodiazepine-related medications (BBRMs) are anxiolytics and hypnotics acting on amino butyric acid (GABA)A receptors. BBRMs are assumed to have a low potential for major congenital malformations, but research on more subtle and protracted developing symptoms of these medications is lacking. Therefore, we prospectively investigated the association between BBRM use in pregnancy and long-term effects on child behavior in a large population-based cohort study. The study population consisted of 104 children prenatally exposed to BBRM, 527 children exposed to maternal prenatal anxiety or phobic anxiety symptoms (without exposure to BBRM), and 5609 control children. At child age, 6 years, Oppositional Defiant Disorder (ODD), Aggressive Behavior and Anxiety Problems were assessed by the Child Behavior Checklist (CBCL) reported by the mother and the Teacher Report Form (TRF). Children prenatally exposed to BBRM had higher scores of ODD and aggressive behavior, but not of anxiety. However, these associations were explained by maternal anxiety symptoms during pregnancy. Moreover, prenatal exposure to anxiety (without exposure to BBRM) was associated with increased scores of child ODD, aggressive behavior, and anxiety. In conclusion, the current study demonstrates that prenatal BBRM exposure was not independently associated with ODD and aggressive behavior in childhood when prenatal anxiety symptoms were taken into account.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Neurotoxicology and Teratology", title = "Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study", volume = "61", pages = "58-65", doi = "10.1016/j.ntt.2017.02.005" }
Radojcić, M. R., El Marroun, H., Miljković, B., Stricker, B. H. C., Jaddoe, V. W. V., Verhulst, F. C., White, T.,& Tiemeier, H.. (2017). Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study. in Neurotoxicology and Teratology Pergamon-Elsevier Science Ltd, Oxford., 61, 58-65. https://doi.org/10.1016/j.ntt.2017.02.005
Radojcić MR, El Marroun H, Miljković B, Stricker BHC, Jaddoe VWV, Verhulst FC, White T, Tiemeier H. Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study. in Neurotoxicology and Teratology. 2017;61:58-65. doi:10.1016/j.ntt.2017.02.005 .
Radojcić, Maja R., El Marroun, Hanan, Miljković, Branislava, Stricker, Bruno H. C., Jaddoe, Vincent W. V., Verhulst, Frank C., White, Tonya, Tiemeier, Henning, "Prenatal exposure to anxiolytic and hypnotic medication in relation to behavioral problems in childhood: A population-based cohort study" in Neurotoxicology and Teratology, 61 (2017):58-65, https://doi.org/10.1016/j.ntt.2017.02.005 . .