Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities
Само за регистроване кориснике
2017
Аутори
Popović, VišnjaTomić, Maja
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Stepanović-Petrović, Radica
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Micov, Ana
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Milenković, Marina
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Petrović, Silvana
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Ušjak, Ljuboš
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Niketić, Marjan
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Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
Phenolic compounds and different biological activities of the dry MeOH extracts of the flowers and the herb (aerial parts without flowers) of Laserpitium zernyi HAYEK (Apiaceae) were investigated. The total phenolic contents in the extracts were determined spectrophotometrically using Folin-Ciocalteu reagent. In both extracts, apigenin, luteolin, their 7-O-glucosides, and chlorogenic acid were detected by HPLC. Identified phenolics were quantified in both extracts, except luteolin in L. zernyi herb extract. The extracts (p.o.) were tested for anti-edematous activity in a model of carrageenan (i.pl.) induced rat paw edema. Antioxidant activity of the extracts was assessed by FRAP assay and DPPH and OH radicals scavenging tests. Antimicrobial activity was investigated using broth microdilution test against five Gram-positive and three Gram-negative bacteria, as well as against two strains of Candida albicans. The polyphenol-richer flower extract exerted higher anti-edematous and antioxid...ant activities. The herb extract exhibited better antimicrobial effect against Micrococcus luteus, Enterococcus faecalis, Bacillus subtilis, and Pseudomonas aeruginosa, while against other tested microorganisms, the activity of both extracts was identical. Demonstrated biological activities of L. zernyi flower and herb extracts represent a good basis for their further investigation as potential new herbal medicinal raw materials.
Извор:
Chemistry & Biodiversity, 2017, 14, 5Издавач:
- Wiley-VCH Verlag GMBH, Weinheim
Финансирање / пројекти:
- Испитивање механизма дејства, интеракција и токсичних ефеката адјувантних аналгетика (RS-MESTD-Basic Research (BR or ON)-175045)
- Испитивање лековитог потенцијала биљака: морфолошка, хемијска и фармаколошка карактеризација (RS-MESTD-Basic Research (BR or ON)-173021)
DOI: 10.1002/cbdv.201600432
ISSN: 1612-1872
PubMed: 27981797
WoS: 000401239300009
Scopus: 2-s2.0-85018265334
Институција/група
PharmacyTY - JOUR AU - Popović, Višnja AU - Tomić, Maja AU - Stepanović-Petrović, Radica AU - Micov, Ana AU - Milenković, Marina AU - Petrović, Silvana AU - Ušjak, Ljuboš AU - Niketić, Marjan PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3026 AB - Phenolic compounds and different biological activities of the dry MeOH extracts of the flowers and the herb (aerial parts without flowers) of Laserpitium zernyi HAYEK (Apiaceae) were investigated. The total phenolic contents in the extracts were determined spectrophotometrically using Folin-Ciocalteu reagent. In both extracts, apigenin, luteolin, their 7-O-glucosides, and chlorogenic acid were detected by HPLC. Identified phenolics were quantified in both extracts, except luteolin in L. zernyi herb extract. The extracts (p.o.) were tested for anti-edematous activity in a model of carrageenan (i.pl.) induced rat paw edema. Antioxidant activity of the extracts was assessed by FRAP assay and DPPH and OH radicals scavenging tests. Antimicrobial activity was investigated using broth microdilution test against five Gram-positive and three Gram-negative bacteria, as well as against two strains of Candida albicans. The polyphenol-richer flower extract exerted higher anti-edematous and antioxidant activities. The herb extract exhibited better antimicrobial effect against Micrococcus luteus, Enterococcus faecalis, Bacillus subtilis, and Pseudomonas aeruginosa, while against other tested microorganisms, the activity of both extracts was identical. Demonstrated biological activities of L. zernyi flower and herb extracts represent a good basis for their further investigation as potential new herbal medicinal raw materials. PB - Wiley-VCH Verlag GMBH, Weinheim T2 - Chemistry & Biodiversity T1 - Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities VL - 14 IS - 5 DO - 10.1002/cbdv.201600432 ER -
@article{ author = "Popović, Višnja and Tomić, Maja and Stepanović-Petrović, Radica and Micov, Ana and Milenković, Marina and Petrović, Silvana and Ušjak, Ljuboš and Niketić, Marjan", year = "2017", abstract = "Phenolic compounds and different biological activities of the dry MeOH extracts of the flowers and the herb (aerial parts without flowers) of Laserpitium zernyi HAYEK (Apiaceae) were investigated. The total phenolic contents in the extracts were determined spectrophotometrically using Folin-Ciocalteu reagent. In both extracts, apigenin, luteolin, their 7-O-glucosides, and chlorogenic acid were detected by HPLC. Identified phenolics were quantified in both extracts, except luteolin in L. zernyi herb extract. The extracts (p.o.) were tested for anti-edematous activity in a model of carrageenan (i.pl.) induced rat paw edema. Antioxidant activity of the extracts was assessed by FRAP assay and DPPH and OH radicals scavenging tests. Antimicrobial activity was investigated using broth microdilution test against five Gram-positive and three Gram-negative bacteria, as well as against two strains of Candida albicans. The polyphenol-richer flower extract exerted higher anti-edematous and antioxidant activities. The herb extract exhibited better antimicrobial effect against Micrococcus luteus, Enterococcus faecalis, Bacillus subtilis, and Pseudomonas aeruginosa, while against other tested microorganisms, the activity of both extracts was identical. Demonstrated biological activities of L. zernyi flower and herb extracts represent a good basis for their further investigation as potential new herbal medicinal raw materials.", publisher = "Wiley-VCH Verlag GMBH, Weinheim", journal = "Chemistry & Biodiversity", title = "Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities", volume = "14", number = "5", doi = "10.1002/cbdv.201600432" }
Popović, V., Tomić, M., Stepanović-Petrović, R., Micov, A., Milenković, M., Petrović, S., Ušjak, L.,& Niketić, M.. (2017). Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities. in Chemistry & Biodiversity Wiley-VCH Verlag GMBH, Weinheim., 14(5). https://doi.org/10.1002/cbdv.201600432
Popović V, Tomić M, Stepanović-Petrović R, Micov A, Milenković M, Petrović S, Ušjak L, Niketić M. Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities. in Chemistry & Biodiversity. 2017;14(5). doi:10.1002/cbdv.201600432 .
Popović, Višnja, Tomić, Maja, Stepanović-Petrović, Radica, Micov, Ana, Milenković, Marina, Petrović, Silvana, Ušjak, Ljuboš, Niketić, Marjan, "Laserpitium zernyi Hayek Flower and Herb Extracts: Phenolic Compounds, and Anti-edematous, Antioxidant, and Antimicrobial Activities" in Chemistry & Biodiversity, 14, no. 5 (2017), https://doi.org/10.1002/cbdv.201600432 . .