Investigation of the retention mechanisms of amlodipine besylate, bisoprolol fumarate, and their impurities on three different HILIC columns
Samo za registrovane korisnike
2018
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Using theoretical models, retention mechanisms of amlodipine besilate and its impurities D, E, and F were tested, as well as bisoprolol fumarate and its impurities A, C, K, and L. Appropriate theoretical retention models for tested compounds were used, which enabled the determination of retention mechanisms responsible for the separation of tested compounds on three different HILIC column: silica, amino, and diol. In order to describe the effect of ratio of aqueous and organic portion of the mobile phase on the retention behavior of tested compounds, as well as the consideration of shares of partition and adsorption processes in HILIC retention mechanism in all three columns, partitioning and adsorption retention theoretical models were calculated. For this purpose, the water content was varied in the range from 4% to 29%, corresponding to the HILIC region of mobile phase composition. During the experiment, values of other factors of mobile phase were maintained at a constant level. Re...gression coefficients of partition and adsorption retention models and the corresponding determination coefficients were determined (R-2). Partitioning models for all tested compounds on amino column had higher R-2 values, while adsorption models for all compounds tested on silica and diol column had higher R-2 value. [GRAPHICS] .
Ključne reči:
Adsorption model / amlodipine / bisoprolol / HILIC / partitioning model / retention mechanismsIzvor:
Journal of Liquid Chromatography & Related Technologies, 2018, 41, 9, 523-531Izdavač:
- Taylor & Francis Inc, Philadelphia
Finansiranje / projekti:
- Modelovanje različitih hromatografskih sistema sa hemometrijskim pristupom u farmaceutskoj analizi (RS-172052)
DOI: 10.1080/10826076.2018.1476380
ISSN: 1082-6076
WoS: 000448729100008
Scopus: 2-s2.0-85055431229
Institucija/grupa
PharmacyTY - JOUR AU - Kasagić-Vujanović, Irena AU - Jančić-Stojanović, Biljana AU - Ivanović, Darko PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3041 AB - Using theoretical models, retention mechanisms of amlodipine besilate and its impurities D, E, and F were tested, as well as bisoprolol fumarate and its impurities A, C, K, and L. Appropriate theoretical retention models for tested compounds were used, which enabled the determination of retention mechanisms responsible for the separation of tested compounds on three different HILIC column: silica, amino, and diol. In order to describe the effect of ratio of aqueous and organic portion of the mobile phase on the retention behavior of tested compounds, as well as the consideration of shares of partition and adsorption processes in HILIC retention mechanism in all three columns, partitioning and adsorption retention theoretical models were calculated. For this purpose, the water content was varied in the range from 4% to 29%, corresponding to the HILIC region of mobile phase composition. During the experiment, values of other factors of mobile phase were maintained at a constant level. Regression coefficients of partition and adsorption retention models and the corresponding determination coefficients were determined (R-2). Partitioning models for all tested compounds on amino column had higher R-2 values, while adsorption models for all compounds tested on silica and diol column had higher R-2 value. [GRAPHICS] . PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Liquid Chromatography & Related Technologies T1 - Investigation of the retention mechanisms of amlodipine besylate, bisoprolol fumarate, and their impurities on three different HILIC columns VL - 41 IS - 9 SP - 523 EP - 531 DO - 10.1080/10826076.2018.1476380 ER -
@article{ author = "Kasagić-Vujanović, Irena and Jančić-Stojanović, Biljana and Ivanović, Darko", year = "2018", abstract = "Using theoretical models, retention mechanisms of amlodipine besilate and its impurities D, E, and F were tested, as well as bisoprolol fumarate and its impurities A, C, K, and L. Appropriate theoretical retention models for tested compounds were used, which enabled the determination of retention mechanisms responsible for the separation of tested compounds on three different HILIC column: silica, amino, and diol. In order to describe the effect of ratio of aqueous and organic portion of the mobile phase on the retention behavior of tested compounds, as well as the consideration of shares of partition and adsorption processes in HILIC retention mechanism in all three columns, partitioning and adsorption retention theoretical models were calculated. For this purpose, the water content was varied in the range from 4% to 29%, corresponding to the HILIC region of mobile phase composition. During the experiment, values of other factors of mobile phase were maintained at a constant level. Regression coefficients of partition and adsorption retention models and the corresponding determination coefficients were determined (R-2). Partitioning models for all tested compounds on amino column had higher R-2 values, while adsorption models for all compounds tested on silica and diol column had higher R-2 value. [GRAPHICS] .", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Liquid Chromatography & Related Technologies", title = "Investigation of the retention mechanisms of amlodipine besylate, bisoprolol fumarate, and their impurities on three different HILIC columns", volume = "41", number = "9", pages = "523-531", doi = "10.1080/10826076.2018.1476380" }
Kasagić-Vujanović, I., Jančić-Stojanović, B.,& Ivanović, D.. (2018). Investigation of the retention mechanisms of amlodipine besylate, bisoprolol fumarate, and their impurities on three different HILIC columns. in Journal of Liquid Chromatography & Related Technologies Taylor & Francis Inc, Philadelphia., 41(9), 523-531. https://doi.org/10.1080/10826076.2018.1476380
Kasagić-Vujanović I, Jančić-Stojanović B, Ivanović D. Investigation of the retention mechanisms of amlodipine besylate, bisoprolol fumarate, and their impurities on three different HILIC columns. in Journal of Liquid Chromatography & Related Technologies. 2018;41(9):523-531. doi:10.1080/10826076.2018.1476380 .
Kasagić-Vujanović, Irena, Jančić-Stojanović, Biljana, Ivanović, Darko, "Investigation of the retention mechanisms of amlodipine besylate, bisoprolol fumarate, and their impurities on three different HILIC columns" in Journal of Liquid Chromatography & Related Technologies, 41, no. 9 (2018):523-531, https://doi.org/10.1080/10826076.2018.1476380 . .