Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design
Apstrakt
Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.
Ključne reči:
Acetylsalicylic acid / CAS 103-90-2 / CAS 50-78-2 / Dissolution testing / Paracetamol / Tablets / experimental design / factorial designIzvor:
Drugs Made in Germany, 2001, 44, 1, 19-24Izdavač:
- Editio Cantor Verlag GmbH
Institucija/grupa
PharmacyTY - JOUR AU - Parojčić, Jelena AU - Đurić, Zorica AU - Jovanović, M AU - Ibrić, Svetlana AU - Nikolić, L PY - 2001 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/304 AB - Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape. PB - Editio Cantor Verlag GmbH T2 - Drugs Made in Germany T1 - Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design VL - 44 IS - 1 SP - 19 EP - 24 UR - https://hdl.handle.net/21.15107/rcub_farfar_304 ER -
@article{ author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Nikolić, L", year = "2001", abstract = "Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.", publisher = "Editio Cantor Verlag GmbH", journal = "Drugs Made in Germany", title = "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design", volume = "44", number = "1", pages = "19-24", url = "https://hdl.handle.net/21.15107/rcub_farfar_304" }
Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Nikolić, L.. (2001). Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Drugs Made in Germany Editio Cantor Verlag GmbH., 44(1), 19-24. https://hdl.handle.net/21.15107/rcub_farfar_304
Parojčić J, Đurić Z, Jovanović M, Ibrić S, Nikolić L. Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Drugs Made in Germany. 2001;44(1):19-24. https://hdl.handle.net/21.15107/rcub_farfar_304 .
Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Nikolić, L, "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design" in Drugs Made in Germany, 44, no. 1 (2001):19-24, https://hdl.handle.net/21.15107/rcub_farfar_304 .