The influence of oxidative stress on cardiac remodeling in obese adolescents
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2018
Authors
Paripović, DušanKotur-Stevuljević, Jelena
Vukašinović, Aleksandra
Ilisić, Tamara
Miloševski-Lomić, Gordana
Peco-Antić, Amira
Article (Published version)
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Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide ...anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension.
Keywords:
Ambulatory blood pressure monitoring / left ventricular hypertrophy / oxidative stress / hypertension / obesitySource:
Scandinavian Journal of Clinical and Laboratory Investigation, 2018, 78, 7-8, 595-600Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Role of biomarkers in early detection of kidney injury and monitoring of therapy response in chidren (RS-MESTD-Basic Research (BR or ON)-175079)
DOI: 10.1080/00365513.2018.1528504
ISSN: 0036-5513
PubMed: 30755099
WoS: 000454770900012
Scopus: 2-s2.0-85059521799
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PharmacyTY - JOUR AU - Paripović, Dušan AU - Kotur-Stevuljević, Jelena AU - Vukašinović, Aleksandra AU - Ilisić, Tamara AU - Miloševski-Lomić, Gordana AU - Peco-Antić, Amira PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3144 AB - Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension. PB - Taylor & Francis Ltd, Abingdon T2 - Scandinavian Journal of Clinical and Laboratory Investigation T1 - The influence of oxidative stress on cardiac remodeling in obese adolescents VL - 78 IS - 7-8 SP - 595 EP - 600 DO - 10.1080/00365513.2018.1528504 ER -
@article{ author = "Paripović, Dušan and Kotur-Stevuljević, Jelena and Vukašinović, Aleksandra and Ilisić, Tamara and Miloševski-Lomić, Gordana and Peco-Antić, Amira", year = "2018", abstract = "Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Scandinavian Journal of Clinical and Laboratory Investigation", title = "The influence of oxidative stress on cardiac remodeling in obese adolescents", volume = "78", number = "7-8", pages = "595-600", doi = "10.1080/00365513.2018.1528504" }
Paripović, D., Kotur-Stevuljević, J., Vukašinović, A., Ilisić, T., Miloševski-Lomić, G.,& Peco-Antić, A.. (2018). The influence of oxidative stress on cardiac remodeling in obese adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation Taylor & Francis Ltd, Abingdon., 78(7-8), 595-600. https://doi.org/10.1080/00365513.2018.1528504
Paripović D, Kotur-Stevuljević J, Vukašinović A, Ilisić T, Miloševski-Lomić G, Peco-Antić A. The influence of oxidative stress on cardiac remodeling in obese adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation. 2018;78(7-8):595-600. doi:10.1080/00365513.2018.1528504 .
Paripović, Dušan, Kotur-Stevuljević, Jelena, Vukašinović, Aleksandra, Ilisić, Tamara, Miloševski-Lomić, Gordana, Peco-Antić, Amira, "The influence of oxidative stress on cardiac remodeling in obese adolescents" in Scandinavian Journal of Clinical and Laboratory Investigation, 78, no. 7-8 (2018):595-600, https://doi.org/10.1080/00365513.2018.1528504 . .