Synergy between Essential Oils of Calamintha Species (Lamiaceae) and Antibiotics
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The subject of the study was the investigation of the chemical composition and antimicrobial activity of the essential oils (EOs) isolated from Calamintha sylvatica, C. vardarensis, C. nepeta and C. glandulosa, as well as their antibacterial activity in combination with antibiotics. The quantitative and qualitative analysis of EOs was performed using the GC/FID and GC/MS methods. The antimicrobial activity of EOs against six standard bacterial strains and one strain of yeast was tested using the broth microdilution method, while the antimicrobial activity of a combination of essential oils and gentamicin/ciprofloxacin was tested by the checkerboard method. The dominant components (> 10%) of the essential oils were: cis-piperitone epoxide and menthone (C. sylvatica), pulegone and menthone (C. vardarensis), pulegone and piperitenone (C. nepeta), pulegone, piperitenone, menthone and piperitone (C. glandulosa). EOs did not exhibit significant antimicrobial activity except the essential oil... of C. vardarensis which was selectively active against Staphylococcus aureus (MIC - 21.25 mu g/mL). The overall effect of essential oil-antibiotic combinations varied from synergistic (FICI lt = 0.5) to antagonistic (FICI >= 2) depending on the bacterial strain tested.
Ključne reči:
Calamintha species / Essential oil / Antimicrobial activity / Synergistic effectIzvor:
Natural Product Communications, 2018, 13, 3, 371-374Izdavač:
- Sage Publications Inc, Thousand Oaks
Finansiranje / projekti:
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-MESTD-Basic Research (BR or ON)-173021)
DOI: 10.1177/1934578x1801300325
ISSN: 1934-578X
WoS: 000433651800027
Scopus: 2-s2.0-85048165424
Institucija/grupa
PharmacyTY - JOUR AU - Milenković, Marina AU - Stošović, Jelena AU - Slavkovska, Violeta PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3146 AB - The subject of the study was the investigation of the chemical composition and antimicrobial activity of the essential oils (EOs) isolated from Calamintha sylvatica, C. vardarensis, C. nepeta and C. glandulosa, as well as their antibacterial activity in combination with antibiotics. The quantitative and qualitative analysis of EOs was performed using the GC/FID and GC/MS methods. The antimicrobial activity of EOs against six standard bacterial strains and one strain of yeast was tested using the broth microdilution method, while the antimicrobial activity of a combination of essential oils and gentamicin/ciprofloxacin was tested by the checkerboard method. The dominant components (> 10%) of the essential oils were: cis-piperitone epoxide and menthone (C. sylvatica), pulegone and menthone (C. vardarensis), pulegone and piperitenone (C. nepeta), pulegone, piperitenone, menthone and piperitone (C. glandulosa). EOs did not exhibit significant antimicrobial activity except the essential oil of C. vardarensis which was selectively active against Staphylococcus aureus (MIC - 21.25 mu g/mL). The overall effect of essential oil-antibiotic combinations varied from synergistic (FICI lt = 0.5) to antagonistic (FICI >= 2) depending on the bacterial strain tested. PB - Sage Publications Inc, Thousand Oaks T2 - Natural Product Communications T1 - Synergy between Essential Oils of Calamintha Species (Lamiaceae) and Antibiotics VL - 13 IS - 3 SP - 371 EP - 374 DO - 10.1177/1934578x1801300325 UR - https://hdl.handle.net/21.15107/rcub_farfar_3146 ER -
@article{ author = "Milenković, Marina and Stošović, Jelena and Slavkovska, Violeta", year = "2018", abstract = "The subject of the study was the investigation of the chemical composition and antimicrobial activity of the essential oils (EOs) isolated from Calamintha sylvatica, C. vardarensis, C. nepeta and C. glandulosa, as well as their antibacterial activity in combination with antibiotics. The quantitative and qualitative analysis of EOs was performed using the GC/FID and GC/MS methods. The antimicrobial activity of EOs against six standard bacterial strains and one strain of yeast was tested using the broth microdilution method, while the antimicrobial activity of a combination of essential oils and gentamicin/ciprofloxacin was tested by the checkerboard method. The dominant components (> 10%) of the essential oils were: cis-piperitone epoxide and menthone (C. sylvatica), pulegone and menthone (C. vardarensis), pulegone and piperitenone (C. nepeta), pulegone, piperitenone, menthone and piperitone (C. glandulosa). EOs did not exhibit significant antimicrobial activity except the essential oil of C. vardarensis which was selectively active against Staphylococcus aureus (MIC - 21.25 mu g/mL). The overall effect of essential oil-antibiotic combinations varied from synergistic (FICI lt = 0.5) to antagonistic (FICI >= 2) depending on the bacterial strain tested.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Natural Product Communications", title = "Synergy between Essential Oils of Calamintha Species (Lamiaceae) and Antibiotics", volume = "13", number = "3", pages = "371-374", doi = "10.1177/1934578x1801300325", url = "https://hdl.handle.net/21.15107/rcub_farfar_3146" }
Milenković, M., Stošović, J.,& Slavkovska, V.. (2018). Synergy between Essential Oils of Calamintha Species (Lamiaceae) and Antibiotics. in Natural Product Communications Sage Publications Inc, Thousand Oaks., 13(3), 371-374. https://doi.org/10.1177/1934578x1801300325 https://hdl.handle.net/21.15107/rcub_farfar_3146
Milenković M, Stošović J, Slavkovska V. Synergy between Essential Oils of Calamintha Species (Lamiaceae) and Antibiotics. in Natural Product Communications. 2018;13(3):371-374. doi:10.1177/1934578x1801300325 https://hdl.handle.net/21.15107/rcub_farfar_3146 .
Milenković, Marina, Stošović, Jelena, Slavkovska, Violeta, "Synergy between Essential Oils of Calamintha Species (Lamiaceae) and Antibiotics" in Natural Product Communications, 13, no. 3 (2018):371-374, https://doi.org/10.1177/1934578x1801300325 ., https://hdl.handle.net/21.15107/rcub_farfar_3146 .