Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory
Samo za registrovane korisnike
2018
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In the present work functional properties of new, co-processed excipients, Pharmaburst (R) 500, Parteck (R) ODT, Ludiflash (R) and Disintequikn (TM) ODT, intended for direct compression of orally disintegrating tablets (ODTs), were investigated based on dynamic compaction analysis and percolation theory. Tablet disintegration time and mechanical properties have been recognized as critical quality attributes (CQAs) which should be optimized through pharmaceutical development. According to the obtained results, in order to achieve adequate mechanical resistance, excipients exhibiting high compactibility and tabletability are required, while, on the contrary, high porosity excipients with higher extent of elastic deformations, average tabletability and compactibility are necessary to obtain fast tablet disintegration. The results obtained in this study indicate that the most important excipient properties affecting tablet CQAs are porosity, mechanism of consolidation, compactibility and t...abletability. Pharmaburst (R) 500, excipient with the highest elastic recovery, the lowest relative density, average compactibility and tabletability, and remarkably high dilution capacity (69.6% w/w of caffeine or 49.1% w/w of ibuprofen) exhibited favourable performance for ODT direct compression. Dynamic compaction analysis and percolation theory proved to be useful tools which can contribute to identification of the most important excipient functional properties influencing critical quality attributes of the prepared ODTs.
Ključne reči:
Critical quality attributes / Functional property / Percolation threshold / Compressibility / Compactibility / TabletabilityIzvor:
Powder Technology, 2018, 326, 292-301Izdavač:
- Elsevier Science BV, Amsterdam
Finansiranje / projekti:
- Razvoj proizvoda i tehnologija koje obezbeđuju željeno oslobađanje lekovitih supstanci iz čvrstih farmaceutskih oblika (RS-MESTD-Technological Development (TD or TR)-34007)
DOI: 10.1016/j.powtec.2017.12.021
ISSN: 0032-5910
WoS: 000425077200034
Scopus: 2-s2.0-85038807236
Institucija/grupa
PharmacyTY - JOUR AU - Drašković, Milica AU - Đuriš, Jelena AU - Ibrić, Svetlana AU - Parojčić, Jelena PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3184 AB - In the present work functional properties of new, co-processed excipients, Pharmaburst (R) 500, Parteck (R) ODT, Ludiflash (R) and Disintequikn (TM) ODT, intended for direct compression of orally disintegrating tablets (ODTs), were investigated based on dynamic compaction analysis and percolation theory. Tablet disintegration time and mechanical properties have been recognized as critical quality attributes (CQAs) which should be optimized through pharmaceutical development. According to the obtained results, in order to achieve adequate mechanical resistance, excipients exhibiting high compactibility and tabletability are required, while, on the contrary, high porosity excipients with higher extent of elastic deformations, average tabletability and compactibility are necessary to obtain fast tablet disintegration. The results obtained in this study indicate that the most important excipient properties affecting tablet CQAs are porosity, mechanism of consolidation, compactibility and tabletability. Pharmaburst (R) 500, excipient with the highest elastic recovery, the lowest relative density, average compactibility and tabletability, and remarkably high dilution capacity (69.6% w/w of caffeine or 49.1% w/w of ibuprofen) exhibited favourable performance for ODT direct compression. Dynamic compaction analysis and percolation theory proved to be useful tools which can contribute to identification of the most important excipient functional properties influencing critical quality attributes of the prepared ODTs. PB - Elsevier Science BV, Amsterdam T2 - Powder Technology T1 - Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory VL - 326 SP - 292 EP - 301 DO - 10.1016/j.powtec.2017.12.021 ER -
@article{ author = "Drašković, Milica and Đuriš, Jelena and Ibrić, Svetlana and Parojčić, Jelena", year = "2018", abstract = "In the present work functional properties of new, co-processed excipients, Pharmaburst (R) 500, Parteck (R) ODT, Ludiflash (R) and Disintequikn (TM) ODT, intended for direct compression of orally disintegrating tablets (ODTs), were investigated based on dynamic compaction analysis and percolation theory. Tablet disintegration time and mechanical properties have been recognized as critical quality attributes (CQAs) which should be optimized through pharmaceutical development. According to the obtained results, in order to achieve adequate mechanical resistance, excipients exhibiting high compactibility and tabletability are required, while, on the contrary, high porosity excipients with higher extent of elastic deformations, average tabletability and compactibility are necessary to obtain fast tablet disintegration. The results obtained in this study indicate that the most important excipient properties affecting tablet CQAs are porosity, mechanism of consolidation, compactibility and tabletability. Pharmaburst (R) 500, excipient with the highest elastic recovery, the lowest relative density, average compactibility and tabletability, and remarkably high dilution capacity (69.6% w/w of caffeine or 49.1% w/w of ibuprofen) exhibited favourable performance for ODT direct compression. Dynamic compaction analysis and percolation theory proved to be useful tools which can contribute to identification of the most important excipient functional properties influencing critical quality attributes of the prepared ODTs.", publisher = "Elsevier Science BV, Amsterdam", journal = "Powder Technology", title = "Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory", volume = "326", pages = "292-301", doi = "10.1016/j.powtec.2017.12.021" }
Drašković, M., Đuriš, J., Ibrić, S.,& Parojčić, J.. (2018). Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory. in Powder Technology Elsevier Science BV, Amsterdam., 326, 292-301. https://doi.org/10.1016/j.powtec.2017.12.021
Drašković M, Đuriš J, Ibrić S, Parojčić J. Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory. in Powder Technology. 2018;326:292-301. doi:10.1016/j.powtec.2017.12.021 .
Drašković, Milica, Đuriš, Jelena, Ibrić, Svetlana, Parojčić, Jelena, "Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory" in Powder Technology, 326 (2018):292-301, https://doi.org/10.1016/j.powtec.2017.12.021 . .