Uncertainty of Measurement in Laboratory Medicine
Apstrakt
An adequate assessment of the measurement uncertainty in a laboratory medicine is one of the most important factors for a reliable interpretation of the results. A large number of standards and guidelines indicate the need for a proper assessment of the uncertainty of measurement results in routine laboratory practice. The available documents gene rally recommend participation in the proficiency schemes/external quality control, as well as the internal quality control, in order to primarily verify the quality performance of the method. Although all documents meet the requirements of the International Standard, ISO 15189, the standard itself does not clearly define the method by which the measurement results need to be assessed and there is no harmonization in practice regarding to this. Also, the uncertainty of measurement results is the data relating to the measured result itself, but all factors that influence the interpretation of the measured value, which is ultimately used for dia...gnosis and monitoring of the patient's treatment, should be taken into account. So in laboratory medicine, an appropriate assessment of the uncertainty of the measurement results should have the ultimate goal of reducing diagnostic uncertainty. However, good professional laboratory practice and understanding analytical aspects of the test for each individual laboratory is necessary to adequately define the uncertainty of measurement results for specific laboratory tests, which helps to implement good clinical practice. Also, setting diagnoses in medicine is a decision with a certain degree of uncertainty, rather than statistically and mathematically calculated conclusion.
Ključne reči:
ISO 15189 / laboratory medicine / measurement uncertaintyIzvor:
Journal of Medical Biochemistry, 2018, 37, 3, 279-288Izdavač:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Finansiranje / projekti:
- Biomarkeri oštećenja i disfunkcije organa (RS-175036)
DOI: 10.2478/jomb-2018-0002
ISSN: 1452-8258
PubMed: 30584397
WoS: 000439420700001
Scopus: 2-s2.0-85047090787
Institucija/grupa
PharmacyTY - JOUR AU - Milinković, Neda AU - Ignjatović, Svetlana AU - Šumarac, Zorica AU - Majkić-Singh, Nada PY - 2018 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3210 AB - An adequate assessment of the measurement uncertainty in a laboratory medicine is one of the most important factors for a reliable interpretation of the results. A large number of standards and guidelines indicate the need for a proper assessment of the uncertainty of measurement results in routine laboratory practice. The available documents gene rally recommend participation in the proficiency schemes/external quality control, as well as the internal quality control, in order to primarily verify the quality performance of the method. Although all documents meet the requirements of the International Standard, ISO 15189, the standard itself does not clearly define the method by which the measurement results need to be assessed and there is no harmonization in practice regarding to this. Also, the uncertainty of measurement results is the data relating to the measured result itself, but all factors that influence the interpretation of the measured value, which is ultimately used for diagnosis and monitoring of the patient's treatment, should be taken into account. So in laboratory medicine, an appropriate assessment of the uncertainty of the measurement results should have the ultimate goal of reducing diagnostic uncertainty. However, good professional laboratory practice and understanding analytical aspects of the test for each individual laboratory is necessary to adequately define the uncertainty of measurement results for specific laboratory tests, which helps to implement good clinical practice. Also, setting diagnoses in medicine is a decision with a certain degree of uncertainty, rather than statistically and mathematically calculated conclusion. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Uncertainty of Measurement in Laboratory Medicine VL - 37 IS - 3 SP - 279 EP - 288 DO - 10.2478/jomb-2018-0002 ER -
@article{ author = "Milinković, Neda and Ignjatović, Svetlana and Šumarac, Zorica and Majkić-Singh, Nada", year = "2018", abstract = "An adequate assessment of the measurement uncertainty in a laboratory medicine is one of the most important factors for a reliable interpretation of the results. A large number of standards and guidelines indicate the need for a proper assessment of the uncertainty of measurement results in routine laboratory practice. The available documents gene rally recommend participation in the proficiency schemes/external quality control, as well as the internal quality control, in order to primarily verify the quality performance of the method. Although all documents meet the requirements of the International Standard, ISO 15189, the standard itself does not clearly define the method by which the measurement results need to be assessed and there is no harmonization in practice regarding to this. Also, the uncertainty of measurement results is the data relating to the measured result itself, but all factors that influence the interpretation of the measured value, which is ultimately used for diagnosis and monitoring of the patient's treatment, should be taken into account. So in laboratory medicine, an appropriate assessment of the uncertainty of the measurement results should have the ultimate goal of reducing diagnostic uncertainty. However, good professional laboratory practice and understanding analytical aspects of the test for each individual laboratory is necessary to adequately define the uncertainty of measurement results for specific laboratory tests, which helps to implement good clinical practice. Also, setting diagnoses in medicine is a decision with a certain degree of uncertainty, rather than statistically and mathematically calculated conclusion.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Uncertainty of Measurement in Laboratory Medicine", volume = "37", number = "3", pages = "279-288", doi = "10.2478/jomb-2018-0002" }
Milinković, N., Ignjatović, S., Šumarac, Z.,& Majkić-Singh, N.. (2018). Uncertainty of Measurement in Laboratory Medicine. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 37(3), 279-288. https://doi.org/10.2478/jomb-2018-0002
Milinković N, Ignjatović S, Šumarac Z, Majkić-Singh N. Uncertainty of Measurement in Laboratory Medicine. in Journal of Medical Biochemistry. 2018;37(3):279-288. doi:10.2478/jomb-2018-0002 .
Milinković, Neda, Ignjatović, Svetlana, Šumarac, Zorica, Majkić-Singh, Nada, "Uncertainty of Measurement in Laboratory Medicine" in Journal of Medical Biochemistry, 37, no. 3 (2018):279-288, https://doi.org/10.2478/jomb-2018-0002 . .