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Influence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differences
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Petrović, Raisa | |
dc.creator | Živković, Irena | |
dc.creator | Bufan, Biljana | |
dc.creator | Stoiljković, Vera | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2019-09-02T12:09:04Z | |
dc.date.available | 2019-09-02T12:09:04Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1389-5729 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3266 | |
dc.description.abstract | The study examined sex-specificities in age-related changes in BALB/c mice IgG antibody responses to immunisation with trivalent inactivated split-virus influenza bulk. Aging diminished the total serum IgG antibody responses to H1N1 and H3N2 and B influenza virus antigens in mice of both sexes, but they remained greater in aged females. This sex difference in aged mice correlated with the greater post-immunisation increase in the frequency of spleen germinal centre (GC) B cells and more favourable T follicular regulatory (Tfr)/GC B cell ratio, as Tfr cells are suggested to control antibody production through suppression of glycolysis. The greater post-immunisation GC B cell response in aged females compared with males correlated with the greater proliferation of B cells and CD4+ cells in splenocyte cultures from aged females restimulated with inactivated split-virus influenza from the bulk. To support the greater post-immunisation increase in the frequency GC B cell in aged females was more favourable Tfr/T follicular helper (Tfh) cell ratio. Additionally, compared with aged males, in age-matched females the greater avidity of serum IgG antibodies was found. However, in aged females IgG2a/IgG1 antibody ratio, reflecting spleen Th1/Th2 cytokine balance, was shifted towards IgG1 when compared with age-matched male mice. This shift was ascribed to a more prominent decline in the titres of functionally important IgG2a antibodies in females with aging. The study suggest that biological sex should be considered as a variable in designing strategies to manipulate with immune outcome of immunisation in aged animals, and possibly, at very long distance, humans. | en |
dc.publisher | Springer, New York | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | restrictedAccess | |
dc.source | Biogerontology | |
dc.subject | Aging | en |
dc.subject | Sex differences | en |
dc.subject | Influenza vaccine | en |
dc.subject | IgG antibody avidity | en |
dc.subject | IgG2a | en |
dc.subject | IgG1 ratio | en |
dc.subject | Tfr | en |
dc.subject | Tfh cell ratio | en |
dc.title | Influence of aging on germinal centre reaction and antibody response to inactivated influenza virus antigens in mice: sex-based differences | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Лепосавић, Гордана; Стоиљковић, Вера; Живковић, Ирена; Буфан, Биљана; Петровић, Раиса; Aрсеновић-Ранин, Невена; | |
dc.citation.volume | 20 | |
dc.citation.issue | 4 | |
dc.citation.spage | 475 | |
dc.citation.epage | 496 | |
dc.citation.other | 20(4): 475-496 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000472839400008 | |
dc.identifier.doi | 10.1007/s10522-019-09811-8 | |
dc.identifier.pmid | 31049769 | |
dc.identifier.scopus | 2-s2.0-85065293816 | |
dc.type.version | publishedVersion |