Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen
Нема приказа
Аутори
Đekić, LjiljanaMartinović, Martina
Dobričić, Vladimir
Čalija, Bojan
Medarević, Đorđe
Primorac, Marija
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The study is focused on formulation of biocompatible hydrogels with a poorly soluble drug ibuprofen (5%) and comprehensive evaluation and comparison of effect of different bioadhesive polymers on their suitability for application on skin, physical stability during the accelerated and natural aging tests (by performing centrifugation test, light microscopy, differential scanning calorimetry, rheological and pH measurements), and in vitro drug release kinetics. Hydrogels, formulated with xanthan gum 1% (XIB), sodium carboxymethylcellulose 5% (CMCIB), poloxamer 407 16% (PIB), and carbomer 1% (KIB), were soft pseudoplastic semisolids with thixotropy and biocompatible pH. The type of the polymer significantly affected apparent viscosity of the hydrogels and miscibility rate with artificial sweat, their physical stability, and shape, size, and aggregation of the drug crystals and degree of crystallization. The drug release in all investigated hydrogels was diffusion-controlled in accordance ...with the Higuchi model and sustained for 12 h, with the drug release rate and the amount of drug released depended on the polymer. The described formulation approach enabled discrimination of the hydrogels with unsatisfactory application properties (CMCIB) and physical stability (KIB), and selection of the hydrogel with promising characteristics in terms of all investigated aspects (XIB) which could be considered for further evaluation.
Кључне речи:
biocompatible hydrogels / xanthan gum / sodium carboxymethylcellulose / carbomer / poloxamer 407 / ibuprofenИзвор:
Journal of Pharmaceutical Sciences, 2019, 108, 3, 1326-1333Издавач:
- Elsevier Science Inc, New York
Финансирање / пројекти:
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.1016/j.xphs.2018.10.054
ISSN: 0022-3549
PubMed: 30395827
WoS: 000460009900030
Scopus: 2-s2.0-85058561248
Институција/група
PharmacyTY - JOUR AU - Đekić, Ljiljana AU - Martinović, Martina AU - Dobričić, Vladimir AU - Čalija, Bojan AU - Medarević, Đorđe AU - Primorac, Marija PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3305 AB - The study is focused on formulation of biocompatible hydrogels with a poorly soluble drug ibuprofen (5%) and comprehensive evaluation and comparison of effect of different bioadhesive polymers on their suitability for application on skin, physical stability during the accelerated and natural aging tests (by performing centrifugation test, light microscopy, differential scanning calorimetry, rheological and pH measurements), and in vitro drug release kinetics. Hydrogels, formulated with xanthan gum 1% (XIB), sodium carboxymethylcellulose 5% (CMCIB), poloxamer 407 16% (PIB), and carbomer 1% (KIB), were soft pseudoplastic semisolids with thixotropy and biocompatible pH. The type of the polymer significantly affected apparent viscosity of the hydrogels and miscibility rate with artificial sweat, their physical stability, and shape, size, and aggregation of the drug crystals and degree of crystallization. The drug release in all investigated hydrogels was diffusion-controlled in accordance with the Higuchi model and sustained for 12 h, with the drug release rate and the amount of drug released depended on the polymer. The described formulation approach enabled discrimination of the hydrogels with unsatisfactory application properties (CMCIB) and physical stability (KIB), and selection of the hydrogel with promising characteristics in terms of all investigated aspects (XIB) which could be considered for further evaluation. PB - Elsevier Science Inc, New York T2 - Journal of Pharmaceutical Sciences T1 - Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen VL - 108 IS - 3 SP - 1326 EP - 1333 DO - 10.1016/j.xphs.2018.10.054 ER -
@article{ author = "Đekić, Ljiljana and Martinović, Martina and Dobričić, Vladimir and Čalija, Bojan and Medarević, Đorđe and Primorac, Marija", year = "2019", abstract = "The study is focused on formulation of biocompatible hydrogels with a poorly soluble drug ibuprofen (5%) and comprehensive evaluation and comparison of effect of different bioadhesive polymers on their suitability for application on skin, physical stability during the accelerated and natural aging tests (by performing centrifugation test, light microscopy, differential scanning calorimetry, rheological and pH measurements), and in vitro drug release kinetics. Hydrogels, formulated with xanthan gum 1% (XIB), sodium carboxymethylcellulose 5% (CMCIB), poloxamer 407 16% (PIB), and carbomer 1% (KIB), were soft pseudoplastic semisolids with thixotropy and biocompatible pH. The type of the polymer significantly affected apparent viscosity of the hydrogels and miscibility rate with artificial sweat, their physical stability, and shape, size, and aggregation of the drug crystals and degree of crystallization. The drug release in all investigated hydrogels was diffusion-controlled in accordance with the Higuchi model and sustained for 12 h, with the drug release rate and the amount of drug released depended on the polymer. The described formulation approach enabled discrimination of the hydrogels with unsatisfactory application properties (CMCIB) and physical stability (KIB), and selection of the hydrogel with promising characteristics in terms of all investigated aspects (XIB) which could be considered for further evaluation.", publisher = "Elsevier Science Inc, New York", journal = "Journal of Pharmaceutical Sciences", title = "Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen", volume = "108", number = "3", pages = "1326-1333", doi = "10.1016/j.xphs.2018.10.054" }
Đekić, L., Martinović, M., Dobričić, V., Čalija, B., Medarević, Đ.,& Primorac, M.. (2019). Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen. in Journal of Pharmaceutical Sciences Elsevier Science Inc, New York., 108(3), 1326-1333. https://doi.org/10.1016/j.xphs.2018.10.054
Đekić L, Martinović M, Dobričić V, Čalija B, Medarević Đ, Primorac M. Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen. in Journal of Pharmaceutical Sciences. 2019;108(3):1326-1333. doi:10.1016/j.xphs.2018.10.054 .
Đekić, Ljiljana, Martinović, Martina, Dobričić, Vladimir, Čalija, Bojan, Medarević, Đorđe, Primorac, Marija, "Comparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofen" in Journal of Pharmaceutical Sciences, 108, no. 3 (2019):1326-1333, https://doi.org/10.1016/j.xphs.2018.10.054 . .