Prikaz osnovnih podataka o dokumentu
Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia
dc.creator | Micić, Sava | |
dc.creator | Lalić, Nataša | |
dc.creator | Đorđević, Dejan | |
dc.creator | Bojanić, Nebojša | |
dc.creator | Bogavac-Stanojević, Nataša | |
dc.creator | Busetto, Gian Maria | |
dc.creator | Virmani, Ashraf | |
dc.creator | Agarwal, Ashok | |
dc.date.accessioned | 2019-09-02T12:11:12Z | |
dc.date.available | 2019-09-02T12:11:12Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0303-4569 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3347 | |
dc.description.abstract | Carnitine is essential for energy metabolism and spermatozoa maturation. Combining L-carnitine and L-acetylcarnitine with micronutrients has been investigated as a treatment for infertility in men. We evaluated the effects of a therapeutic formulation, Proxeed Plus, on sperm parameters in oligoasthenozoospermic men. This prospective, randomised, double-blind, placebo-controlled clinical trial involved 175 males (19-44 years) with idiopathic oligoasthenozoospermia who failed to impregnate their partners (12 months). Males received Proxeed Plus or placebo for 3 and 6 months. Sperm volume, progressive motility and vitality significantly (p lt 0.001) improved after 6 months compared to baseline. Sperm DNA fragmentation index significantly decreased compared to baseline (p lt 0.001) and the 3-month therapy (p = 0.014) in treated men. Increased seminal carnitine and alpha-glucosidase concentration also positively correlated with improved progressive motility. Decreased DNA fragmentation index was the good predictor of progressive sperm motility >10%, and simultaneous measurement of changes in sperm vitality and DNA fragmentation index gave the highest probability of sperm motility 10% (AUC = 0.924; 95% CI = 0.852-0.996; p lt 0.001). Logistic regression analyses revealed DNA fragmentation index decrease as the only independent predictor of sperm motility 10% (OR = 1.106; p = 0.034). We have demonstrated the beneficial effects of carnitine derivatives on progressive motility, vitality and sperm DNA fragmentation. Combining metabolic and micronutritive factors is beneficial for male infertility. | en |
dc.publisher | Wiley, Hoboken | |
dc.rights | openAccess | |
dc.source | Andrologia | |
dc.subject | L-acetylcarnitine | en |
dc.subject | L-carnitine | en |
dc.subject | male infertility | en |
dc.subject | oligoasthenozoospermia | en |
dc.subject | sperm parameters | en |
dc.title | Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aгарwал, Aсхок; Лалић, Наташа; Ђорђевић, Дејан; Бојанић, Небојша; Вирмани, Aсхраф; Богавац-Станојевић, Наташа; Мицић, Сава; Бусетто, Гиан Мариа; | |
dc.citation.volume | 51 | |
dc.citation.issue | 6 | |
dc.citation.other | 51(6): - | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000469970800018 | |
dc.identifier.doi | 10.1111/and.13267 | |
dc.identifier.pmid | 30873633 | |
dc.identifier.scopus | 2-s2.0-85066784345 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1912/3345.pdf | |
dc.type.version | publishedVersion |