Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)
Abstract
The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).
Keywords:
Chickpea / total polyphenol / total flavonoid / antioxidant activity / central composite designSource:
Solid State Ionics, 2019, 54, 5, 837-846Publisher:
- Taylor & Francis Inc, Philadelphia
Funding / projects:
- Plants and synthetic bioactive products of new generation (RS-MESTD-Technological Development (TD or TR)-34012)
DOI: 10.1080/01496395.2018.1520720
ISSN: 0149-6395
WoS: 000464574300018
Scopus: 2-s2.0-85053510649
Collections
Institution/Community
PharmacyTY - JOUR AU - Savić, Ivan AU - Nikolić, Ivana Lj. AU - Savić-Gajić, Ivana AU - Kundaković, Tatjana PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3362 AB - The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3). PB - Taylor & Francis Inc, Philadelphia T2 - Solid State Ionics T1 - Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L) VL - 54 IS - 5 SP - 837 EP - 846 DO - 10.1080/01496395.2018.1520720 ER -
@article{ author = "Savić, Ivan and Nikolić, Ivana Lj. and Savić-Gajić, Ivana and Kundaković, Tatjana", year = "2019", abstract = "The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Solid State Ionics", title = "Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)", volume = "54", number = "5", pages = "837-846", doi = "10.1080/01496395.2018.1520720" }
Savić, I., Nikolić, I. Lj., Savić-Gajić, I.,& Kundaković, T.. (2019). Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L). in Solid State Ionics Taylor & Francis Inc, Philadelphia., 54(5), 837-846. https://doi.org/10.1080/01496395.2018.1520720
Savić I, Nikolić IL, Savić-Gajić I, Kundaković T. Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L). in Solid State Ionics. 2019;54(5):837-846. doi:10.1080/01496395.2018.1520720 .
Savić, Ivan, Nikolić, Ivana Lj., Savić-Gajić, Ivana, Kundaković, Tatjana, "Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)" in Solid State Ionics, 54, no. 5 (2019):837-846, https://doi.org/10.1080/01496395.2018.1520720 . .