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Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography
dc.creator | Filipić, Slavica | |
dc.creator | Shenger, Musbah Salem Mohamed | |
dc.creator | Nikolić, Katarina | |
dc.creator | Agbaba, Danica | |
dc.date.accessioned | 2019-09-14T21:39:49Z | |
dc.date.available | 2016-03-18 | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1082-6076 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2391 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3439 | |
dc.description.abstract | A thin-layer chromatographic method for simultaneous determination of moxonidine and its four impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60F(254) and using methanol-toluene-dichloroethane-ammonia 2:3:3:0.1 (v/v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile phase vapors for 15min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 260 and 280nm. Regression coefficients (r >= 0.998), recovery (90.10-107.63%), limit of quantification of impurities (20ng band(-1) equivalent to the 0.12% impurity level), and robustness were validated and found satisfactory. The developed method is well suited for quantitative analysis and purity control of moxonidine in its dosage forms. | en |
dc.publisher | Taylor & Francis Inc, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS// | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Liquid Chromatography & Related Technologies | |
dc.subject | pharmaceuticals | en |
dc.subject | moxonidine | en |
dc.subject | method validation | en |
dc.subject | quantitation | en |
dc.subject | impurities | en |
dc.subject | TLC | en |
dc.title | Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Николић, Катарина; Филипић, Славица; Aгбаба, Даница; Схенгер, Мусбах Салем Мохамед; | |
dc.citation.volume | 38 | |
dc.citation.issue | 11 | |
dc.citation.spage | 1121 | |
dc.citation.epage | 1125 | |
dc.citation.other | 38(11): 1121-1125 | |
dc.citation.rank | M23 | |
dc.description.other | This is peer-reviewed version of the following article: Filipic, S.; Shenger, M. S. M.; Nikolic, K.; Agbaba, D. Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography. J. Liq. Chromatogr. Relat. Technol. 2015, 38 (11), 1121–1125. [https://doi.org/10.1080/10826076.2015.1028291] | |
dc.identifier.wos | 000354045900006 | |
dc.identifier.doi | 10.1080/10826076.2015.1028291 | |
dc.identifier.scopus | 2-s2.0-84929231814 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/7147/Determination_of_Moxonidine_acc_2015.pdf | |
dc.type.version | publishedVersion | |
dc.type.version | acceptedVersion |