Threshold in the toxicology of metals: Challenges and pitfalls of the concept
Abstract
Metals qualitatively dominate the chemical elements found on Earth, but life has found a use for only a minority of them. Most metals are mobilized as cations, and thereby interact and are processed by living species. Animals are exposed to environmental metals at chronic low concentrations through food, air particles, and other ways, under conditions that are too rarely reproduced in laboratory settings. Actual metal detoxification systems in animals are not many and of limited efficiency which casts doubt on the existence of any safe concentration — a threshold for nonessential metals. Hence the mechanisms of action of toxic metals at very low doses still have to be adequately addressed to provide means for knowledge-based risk assessment that is increasingly requested by diverse communities.
Keywords:
Acceptability / Adaptation / Mechanism of action / Metal burden / Repair / Risk assessmentSource:
Current Opinion in Toxicology, 2020, 19, 28-33Publisher:
- Elsevier
Funding / projects:
- Agence Nationale de la Recherche ANR-13-CESA-008-Cadmidia
- Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)
DOI: 10.1016/j.cotox.2019.10.004
ISSN: 2468-2020
WoS: 000531649300007
Scopus: 2-s2.0-85074611204
Collections
Institution/Community
PharmacyTY - JOUR AU - Moulis, Jean-Marc AU - Bulat, Zorica AU - Buha-Đorđević, Aleksandra PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3520 AB - Metals qualitatively dominate the chemical elements found on Earth, but life has found a use for only a minority of them. Most metals are mobilized as cations, and thereby interact and are processed by living species. Animals are exposed to environmental metals at chronic low concentrations through food, air particles, and other ways, under conditions that are too rarely reproduced in laboratory settings. Actual metal detoxification systems in animals are not many and of limited efficiency which casts doubt on the existence of any safe concentration — a threshold for nonessential metals. Hence the mechanisms of action of toxic metals at very low doses still have to be adequately addressed to provide means for knowledge-based risk assessment that is increasingly requested by diverse communities. PB - Elsevier T2 - Current Opinion in Toxicology T1 - Threshold in the toxicology of metals: Challenges and pitfalls of the concept VL - 19 SP - 28 EP - 33 DO - 10.1016/j.cotox.2019.10.004 ER -
@article{ author = "Moulis, Jean-Marc and Bulat, Zorica and Buha-Đorđević, Aleksandra", year = "2020", abstract = "Metals qualitatively dominate the chemical elements found on Earth, but life has found a use for only a minority of them. Most metals are mobilized as cations, and thereby interact and are processed by living species. Animals are exposed to environmental metals at chronic low concentrations through food, air particles, and other ways, under conditions that are too rarely reproduced in laboratory settings. Actual metal detoxification systems in animals are not many and of limited efficiency which casts doubt on the existence of any safe concentration — a threshold for nonessential metals. Hence the mechanisms of action of toxic metals at very low doses still have to be adequately addressed to provide means for knowledge-based risk assessment that is increasingly requested by diverse communities.", publisher = "Elsevier", journal = "Current Opinion in Toxicology", title = "Threshold in the toxicology of metals: Challenges and pitfalls of the concept", volume = "19", pages = "28-33", doi = "10.1016/j.cotox.2019.10.004" }
Moulis, J., Bulat, Z.,& Buha-Đorđević, A.. (2020). Threshold in the toxicology of metals: Challenges and pitfalls of the concept. in Current Opinion in Toxicology Elsevier., 19, 28-33. https://doi.org/10.1016/j.cotox.2019.10.004
Moulis J, Bulat Z, Buha-Đorđević A. Threshold in the toxicology of metals: Challenges and pitfalls of the concept. in Current Opinion in Toxicology. 2020;19:28-33. doi:10.1016/j.cotox.2019.10.004 .
Moulis, Jean-Marc, Bulat, Zorica, Buha-Đorđević, Aleksandra, "Threshold in the toxicology of metals: Challenges and pitfalls of the concept" in Current Opinion in Toxicology, 19 (2020):28-33, https://doi.org/10.1016/j.cotox.2019.10.004 . .