Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data
Authors
Buha, AleksandraĐukić-Ćosić, Danijela
Ćurčić, Marijana
Bulat, Zorica
Antonijević, Biljana
Moulis, Jean-Marc
Goumenou, Marina
Wallace, David
Article (Published version)
Metadata
Show full item recordAbstract
Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the t...arget tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.
Keywords:
Cadmium / Diabetes / Hyperglycemia / Hyperinsulinemia / Insulin / Lipogenic / ß-cell toxicitySource:
Toxics, 2020, 8, 3Publisher:
- MDPI AG
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200161 (University of Belgrade, Faculty of Pharmacy) (RS-MESTD-inst-2020-200161)
- Oklahoma State UniversityCenter for Health Sciences Pilot/Seed Grant (1-54357; D.W.)
DOI: 10.3390/TOXICS8030063
ISSN: 2305-6304
WoS: 000578879900001
Scopus: 2-s2.0-85090587413
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Institution/Community
PharmacyTY - JOUR AU - Buha, Aleksandra AU - Đukić-Ćosić, Danijela AU - Ćurčić, Marijana AU - Bulat, Zorica AU - Antonijević, Biljana AU - Moulis, Jean-Marc AU - Goumenou, Marina AU - Wallace, David PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3659 AB - Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance. PB - MDPI AG T2 - Toxics T1 - Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data VL - 8 IS - 3 DO - 10.3390/TOXICS8030063 ER -
@article{ author = "Buha, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Moulis, Jean-Marc and Goumenou, Marina and Wallace, David", year = "2020", abstract = "Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.", publisher = "MDPI AG", journal = "Toxics", title = "Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data", volume = "8", number = "3", doi = "10.3390/TOXICS8030063" }
Buha, A., Đukić-Ćosić, D., Ćurčić, M., Bulat, Z., Antonijević, B., Moulis, J., Goumenou, M.,& Wallace, D.. (2020). Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data. in Toxics MDPI AG., 8(3). https://doi.org/10.3390/TOXICS8030063
Buha A, Đukić-Ćosić D, Ćurčić M, Bulat Z, Antonijević B, Moulis J, Goumenou M, Wallace D. Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data. in Toxics. 2020;8(3). doi:10.3390/TOXICS8030063 .
Buha, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Moulis, Jean-Marc, Goumenou, Marina, Wallace, David, "Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data" in Toxics, 8, no. 3 (2020), https://doi.org/10.3390/TOXICS8030063 . .