Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions
Autori
Krkobabić, MirjanaMedarević, Đorđe
Pešić, Nikola
Vasiljević, Dragana
Ivković, Branka
Ibrić, Svetlana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Three-dimensional (3D) printing technologies are based on successive material printing layer-by-layer and are considered suitable for the production of dosage forms customized for a patient’s needs. In this study, tablets of atomoxetine hydrochloride (ATH) have been successfully fabricated by a digital light processing (DLP) 3D printing technology. Initial materials were photoreactive suspensions, composed of poly(ethylene glycol) diacrylate 700 (PEGDA 700), poly(ethylene glycol) 400 (PEG 400), photoinitiator and suspended ATH. The amount of ATH was varied from 10.00 to 25.00% (w/w), and a range of doses from 12.21 to 40.07 mg has been achieved, indicating the possibility of personalized therapy. The rheological characteristics of all photoreactive suspensions were appropriate for the printing process, while the amount of the suspended particles in the photoreactive suspensions had an impact on the 3D printing process, as well as on mechanical and biopharmaceutical characteristics of t...ablets. Only the formulation with the highest content of ATH had significantly different tensile strength compared to other formulations. All tablets showed sustained drug release during at least the 8h. ATH crystals were observed with polarized light microscopy of photoreactive suspensions and the cross-sections of the tablets, while no interactions between ATH and polymers were detected by FT-IR spectroscopy.
Ključne reči:
Photopolymerization / Sustained release / Three-dimensional (3D) printing / Digital light processing (DLP) / Personalized therapy / Photoreactive suspensionsIzvor:
Pharmaceutics, 2020, 12, 9, 1-17Izdavač:
- MDPI AG
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200161 (Univerzitet u Beogradu, Farmaceutski fakultet) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/pharmaceutics12090833
ISSN: 1999-4923
WoS: 000586089800001
Scopus: 2-s2.0-85092435862
Institucija/grupa
PharmacyTY - JOUR AU - Krkobabić, Mirjana AU - Medarević, Đorđe AU - Pešić, Nikola AU - Vasiljević, Dragana AU - Ivković, Branka AU - Ibrić, Svetlana PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3710 AB - Three-dimensional (3D) printing technologies are based on successive material printing layer-by-layer and are considered suitable for the production of dosage forms customized for a patient’s needs. In this study, tablets of atomoxetine hydrochloride (ATH) have been successfully fabricated by a digital light processing (DLP) 3D printing technology. Initial materials were photoreactive suspensions, composed of poly(ethylene glycol) diacrylate 700 (PEGDA 700), poly(ethylene glycol) 400 (PEG 400), photoinitiator and suspended ATH. The amount of ATH was varied from 10.00 to 25.00% (w/w), and a range of doses from 12.21 to 40.07 mg has been achieved, indicating the possibility of personalized therapy. The rheological characteristics of all photoreactive suspensions were appropriate for the printing process, while the amount of the suspended particles in the photoreactive suspensions had an impact on the 3D printing process, as well as on mechanical and biopharmaceutical characteristics of tablets. Only the formulation with the highest content of ATH had significantly different tensile strength compared to other formulations. All tablets showed sustained drug release during at least the 8h. ATH crystals were observed with polarized light microscopy of photoreactive suspensions and the cross-sections of the tablets, while no interactions between ATH and polymers were detected by FT-IR spectroscopy. PB - MDPI AG T2 - Pharmaceutics T1 - Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions VL - 12 IS - 9 SP - 1 EP - 17 DO - 10.3390/pharmaceutics12090833 ER -
@article{ author = "Krkobabić, Mirjana and Medarević, Đorđe and Pešić, Nikola and Vasiljević, Dragana and Ivković, Branka and Ibrić, Svetlana", year = "2020", abstract = "Three-dimensional (3D) printing technologies are based on successive material printing layer-by-layer and are considered suitable for the production of dosage forms customized for a patient’s needs. In this study, tablets of atomoxetine hydrochloride (ATH) have been successfully fabricated by a digital light processing (DLP) 3D printing technology. Initial materials were photoreactive suspensions, composed of poly(ethylene glycol) diacrylate 700 (PEGDA 700), poly(ethylene glycol) 400 (PEG 400), photoinitiator and suspended ATH. The amount of ATH was varied from 10.00 to 25.00% (w/w), and a range of doses from 12.21 to 40.07 mg has been achieved, indicating the possibility of personalized therapy. The rheological characteristics of all photoreactive suspensions were appropriate for the printing process, while the amount of the suspended particles in the photoreactive suspensions had an impact on the 3D printing process, as well as on mechanical and biopharmaceutical characteristics of tablets. Only the formulation with the highest content of ATH had significantly different tensile strength compared to other formulations. All tablets showed sustained drug release during at least the 8h. ATH crystals were observed with polarized light microscopy of photoreactive suspensions and the cross-sections of the tablets, while no interactions between ATH and polymers were detected by FT-IR spectroscopy.", publisher = "MDPI AG", journal = "Pharmaceutics", title = "Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions", volume = "12", number = "9", pages = "1-17", doi = "10.3390/pharmaceutics12090833" }
Krkobabić, M., Medarević, Đ., Pešić, N., Vasiljević, D., Ivković, B.,& Ibrić, S.. (2020). Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions. in Pharmaceutics MDPI AG., 12(9), 1-17. https://doi.org/10.3390/pharmaceutics12090833
Krkobabić M, Medarević Đ, Pešić N, Vasiljević D, Ivković B, Ibrić S. Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions. in Pharmaceutics. 2020;12(9):1-17. doi:10.3390/pharmaceutics12090833 .
Krkobabić, Mirjana, Medarević, Đorđe, Pešić, Nikola, Vasiljević, Dragana, Ivković, Branka, Ibrić, Svetlana, "Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions" in Pharmaceutics, 12, no. 9 (2020):1-17, https://doi.org/10.3390/pharmaceutics12090833 . .