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Supplementation with Octacosanol Affects the Level of PCSK9 and Restore Its Physiologic Relation with LDL-C in Patients on Chronic Statin Therapy
dc.creator | Zrnić-Ćirić, Milica | |
dc.creator | Ostojić, Miodrag | |
dc.creator | Baralić, Ivana | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Đorđević, Brižita | |
dc.creator | Marković, Stana | |
dc.creator | Živković, Stefan | |
dc.creator | Stanković, Ivan | |
dc.date.accessioned | 2021-04-21T08:07:16Z | |
dc.date.available | 2021-04-21T08:07:16Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3818 | |
dc.description.abstract | Dietary supplementation with sugar cane derivates may modulate low-density lipoproteincholesterol (LDL-C) and proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. The purposeof this study was to determine if dietary supplement (DS), containing Octacosanol (20 mg) andvitamin K2 (45μg), could restore the disrupted physiologic relation between LDL-C and serumPCSK9. Double-blind, randomized, placebo-controlled, single-center study including 87 patients onchronic atorvastatin therapy was conducted. Eighty-seven patients were randomized to receive DS(n= 42) or placebo (n= 45), and followed for 13 weeks. Serum PCSK9 levels, lipid parameters andtheir relationship were the main efficacy endpoints. The absolute levels of PCSK9 and LDL-C werenot significantly different from baseline to 13 weeks. However, physiologic correlation between %change of PCSK9 and % change of LDL-C levels was normalized only in the group of patients treatedwith DS (r= 0.409,p= 0.012). This study shows that DS can restore statin disrupted physiologicpositive correlation between PCSK9 and LDL-C. Elevated PCSK9 level is an independent risk factorso controlling its rise by statins may be important in prevention of cardiovascular events. | |
dc.publisher | MDPI | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41022/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Nutrients | |
dc.subject | LDL-C | |
dc.subject | Octacosanol | |
dc.subject | PCSK9 | |
dc.subject | statins | |
dc.subject | supplementation | |
dc.title | Supplementation with Octacosanol Affects the Level of PCSK9 and Restore Its Physiologic Relation with LDL-C in Patients on Chronic Statin Therapy | |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Остојић, Миодраг; Ђорђевић, Брижита; Станковић, Иван; Баралић, Ивана; Марковић, Стана; Живковић, Стефан; Зрнић-Ћирић, Милица; Котур-Стевуљевић, Јелена; | |
dc.citation.volume | 13 | |
dc.citation.issue | 3 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000633994200001 | |
dc.identifier.wos | 000633994200001 | |
dc.identifier.doi | 10.3390/nu13030903 | |
dc.identifier.scopus | 2-s2.0-85103919695 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/8712/Supplementation_with_Octacosanol_pub_2021.pdf | |
dc.type.version | publishedVersion |