Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?
Abstract
Introduction: The aim of our study was to examine the relationship of hepcidin-25 with red blood cell and reticulocyte indices and to evaluate the diagnostic properties of hepcidin-25 in the assessment of positive iron balance in end-stage renal disease (ESRD) patients. Methods: Eighty anemic ESRD patients (hemoglobin < 110 g/L) were classified as having iron deficiency (ID, N = 20), iron sufficiency (IS, N = 29), and positive iron balance (PB, N = 31) using the conventional biomarkers for iron status evaluation. Hepcidin-25 was determined by a chemiluminescent direct ELISA. Results: Hepcidin-25 was significantly negatively correlated with the proportion of hypochromic erythrocytes (%HYPO) (P =.034) and immature reticulocyte fraction (P =.010) in ID and with the absolute reticulocyte concentration in ID (P =.048) and PB (P =.040). In multivariate models, hepcidin-25 was independently negatively associated with the mean reticulocyte hemoglobin content (CHr; β = −0.493, P =.004) and red ...blood cell size factor (RSf) (β = −0.334, P =.036) only in the PB group. The best hepcidin-25 value to exclude PB was 66.13 µg/L, showing a sensitivity of 61.3%, a specificity of 75.5%, and an AUC of 0.808. Conclusion: Our results suggest that hepcidin-25 levels are independently negatively associated with the iron demand for the most recent erythropoiesis only in PB. Hepcidin-25 performed acceptable in discriminating anemic ESRD patients with positive iron balance and may prove to be a useful additional tool in the evaluation of iron status.
Keywords:
anemia / chronic kidney disease / hepcidin / hypochromic red blood cell / reticulocyte hemoglobin contentSource:
International Journal of Laboratory Hematology, 2021, 43, 5, 1159-1167Publisher:
- John Wiley & Sons Ltd
Funding / projects:
DOI: 10.1111/ijlh.13539
ISSN: 1751-5521
WoS: 000638216700001
Scopus: 2-s2.0-85104082896
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Institution/Community
PharmacyTY - JOUR AU - Savković, Miljan AU - Simić-Ogrizović, Sanja AU - Dopsaj, Violeta PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3903 AB - Introduction: The aim of our study was to examine the relationship of hepcidin-25 with red blood cell and reticulocyte indices and to evaluate the diagnostic properties of hepcidin-25 in the assessment of positive iron balance in end-stage renal disease (ESRD) patients. Methods: Eighty anemic ESRD patients (hemoglobin < 110 g/L) were classified as having iron deficiency (ID, N = 20), iron sufficiency (IS, N = 29), and positive iron balance (PB, N = 31) using the conventional biomarkers for iron status evaluation. Hepcidin-25 was determined by a chemiluminescent direct ELISA. Results: Hepcidin-25 was significantly negatively correlated with the proportion of hypochromic erythrocytes (%HYPO) (P =.034) and immature reticulocyte fraction (P =.010) in ID and with the absolute reticulocyte concentration in ID (P =.048) and PB (P =.040). In multivariate models, hepcidin-25 was independently negatively associated with the mean reticulocyte hemoglobin content (CHr; β = −0.493, P =.004) and red blood cell size factor (RSf) (β = −0.334, P =.036) only in the PB group. The best hepcidin-25 value to exclude PB was 66.13 µg/L, showing a sensitivity of 61.3%, a specificity of 75.5%, and an AUC of 0.808. Conclusion: Our results suggest that hepcidin-25 levels are independently negatively associated with the iron demand for the most recent erythropoiesis only in PB. Hepcidin-25 performed acceptable in discriminating anemic ESRD patients with positive iron balance and may prove to be a useful additional tool in the evaluation of iron status. PB - John Wiley & Sons Ltd T2 - International Journal of Laboratory Hematology T1 - Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful? VL - 43 IS - 5 SP - 1159 EP - 1167 DO - 10.1111/ijlh.13539 ER -
@article{ author = "Savković, Miljan and Simić-Ogrizović, Sanja and Dopsaj, Violeta", year = "2021", abstract = "Introduction: The aim of our study was to examine the relationship of hepcidin-25 with red blood cell and reticulocyte indices and to evaluate the diagnostic properties of hepcidin-25 in the assessment of positive iron balance in end-stage renal disease (ESRD) patients. Methods: Eighty anemic ESRD patients (hemoglobin < 110 g/L) were classified as having iron deficiency (ID, N = 20), iron sufficiency (IS, N = 29), and positive iron balance (PB, N = 31) using the conventional biomarkers for iron status evaluation. Hepcidin-25 was determined by a chemiluminescent direct ELISA. Results: Hepcidin-25 was significantly negatively correlated with the proportion of hypochromic erythrocytes (%HYPO) (P =.034) and immature reticulocyte fraction (P =.010) in ID and with the absolute reticulocyte concentration in ID (P =.048) and PB (P =.040). In multivariate models, hepcidin-25 was independently negatively associated with the mean reticulocyte hemoglobin content (CHr; β = −0.493, P =.004) and red blood cell size factor (RSf) (β = −0.334, P =.036) only in the PB group. The best hepcidin-25 value to exclude PB was 66.13 µg/L, showing a sensitivity of 61.3%, a specificity of 75.5%, and an AUC of 0.808. Conclusion: Our results suggest that hepcidin-25 levels are independently negatively associated with the iron demand for the most recent erythropoiesis only in PB. Hepcidin-25 performed acceptable in discriminating anemic ESRD patients with positive iron balance and may prove to be a useful additional tool in the evaluation of iron status.", publisher = "John Wiley & Sons Ltd", journal = "International Journal of Laboratory Hematology", title = "Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?", volume = "43", number = "5", pages = "1159-1167", doi = "10.1111/ijlh.13539" }
Savković, M., Simić-Ogrizović, S.,& Dopsaj, V.. (2021). Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?. in International Journal of Laboratory Hematology John Wiley & Sons Ltd., 43(5), 1159-1167. https://doi.org/10.1111/ijlh.13539
Savković M, Simić-Ogrizović S, Dopsaj V. Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?. in International Journal of Laboratory Hematology. 2021;43(5):1159-1167. doi:10.1111/ijlh.13539 .
Savković, Miljan, Simić-Ogrizović, Sanja, Dopsaj, Violeta, "Assessment of positive iron balance in end-stage renal disease: Could hepcidin-25 be useful?" in International Journal of Laboratory Hematology, 43, no. 5 (2021):1159-1167, https://doi.org/10.1111/ijlh.13539 . .