Particle Deposition in Respiratory Tract: Where are the Limits?
Abstract
In last two decades in silico biopharmaceutics modelling has become increasingly important in all stages of drug development. One of the widely used pharmacokinetic modelling software is Gastro Plus that, with its additional dosage routes modules, enables creation of pharmacokinetic models, amongst others, for pulmonary dosage route. Medicines that are applied via that route have specific methods for characterization and analysis. However, drug that is target of in silico method in Gastro Plus is not characterized in full extent with such parameters. In this work we created various models of size distributions and depositions of two pMDI preparations containing beclomethasone dipropionate in 4 respiratory compartments of Gastro Plus Pulmonary model. Those data were compared with results of in vivo studies and model with best correlation was obtained. Such model with defined cut-off limits between each compartment enables better prediction of pharmacokinetic properties in generated Gast...ro Plus in silico model.
Keywords:
Aerodynamic assessment of particle size / In silico modeling / Lung depositionSource:
Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021, 2021, 84, 638-644Publisher:
- Springer, Cham
Collections
Institution/Community
PharmacyTY - CONF AU - Elezović, Amar AU - Cvijić, Sandra AU - Elezović, Alisa AU - Pilipović, Saša AU - Parojčić, Jelena PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3933 AB - In last two decades in silico biopharmaceutics modelling has become increasingly important in all stages of drug development. One of the widely used pharmacokinetic modelling software is Gastro Plus that, with its additional dosage routes modules, enables creation of pharmacokinetic models, amongst others, for pulmonary dosage route. Medicines that are applied via that route have specific methods for characterization and analysis. However, drug that is target of in silico method in Gastro Plus is not characterized in full extent with such parameters. In this work we created various models of size distributions and depositions of two pMDI preparations containing beclomethasone dipropionate in 4 respiratory compartments of Gastro Plus Pulmonary model. Those data were compared with results of in vivo studies and model with best correlation was obtained. Such model with defined cut-off limits between each compartment enables better prediction of pharmacokinetic properties in generated Gastro Plus in silico model. PB - Springer, Cham C3 - Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021 T1 - Particle Deposition in Respiratory Tract: Where are the Limits? VL - 84 SP - 638 EP - 644 DO - 10.1007/978-3-030-73909-6_74 ER -
@conference{ author = "Elezović, Amar and Cvijić, Sandra and Elezović, Alisa and Pilipović, Saša and Parojčić, Jelena", year = "2021", abstract = "In last two decades in silico biopharmaceutics modelling has become increasingly important in all stages of drug development. One of the widely used pharmacokinetic modelling software is Gastro Plus that, with its additional dosage routes modules, enables creation of pharmacokinetic models, amongst others, for pulmonary dosage route. Medicines that are applied via that route have specific methods for characterization and analysis. However, drug that is target of in silico method in Gastro Plus is not characterized in full extent with such parameters. In this work we created various models of size distributions and depositions of two pMDI preparations containing beclomethasone dipropionate in 4 respiratory compartments of Gastro Plus Pulmonary model. Those data were compared with results of in vivo studies and model with best correlation was obtained. Such model with defined cut-off limits between each compartment enables better prediction of pharmacokinetic properties in generated Gastro Plus in silico model.", publisher = "Springer, Cham", journal = "Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021", title = "Particle Deposition in Respiratory Tract: Where are the Limits?", volume = "84", pages = "638-644", doi = "10.1007/978-3-030-73909-6_74" }
Elezović, A., Cvijić, S., Elezović, A., Pilipović, S.,& Parojčić, J.. (2021). Particle Deposition in Respiratory Tract: Where are the Limits?. in Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021 Springer, Cham., 84, 638-644. https://doi.org/10.1007/978-3-030-73909-6_74
Elezović A, Cvijić S, Elezović A, Pilipović S, Parojčić J. Particle Deposition in Respiratory Tract: Where are the Limits?. in Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021. 2021;84:638-644. doi:10.1007/978-3-030-73909-6_74 .
Elezović, Amar, Cvijić, Sandra, Elezović, Alisa, Pilipović, Saša, Parojčić, Jelena, "Particle Deposition in Respiratory Tract: Where are the Limits?" in Proceedings of the International Conference on Medical and Biological Engineering 2021 (Cmbebih 2021, 84 (2021):638-644, https://doi.org/10.1007/978-3-030-73909-6_74 . .