Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii
Samo za registrovane korisnike
2021
Autori
Mudrić, JelenaArsenijević, Jelena
Maksimović, Zoran
Ibrić, Svetlana
Gopčević, Kristina
Đuriš, Jelena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Aerial parts of Satureja kitaibelii are traditionally used as carminative, for treatment of respiratory and urinary complaints, or as anti-inflammatory agent for skin and mucous membranes. The aim of the present study was to formulate immediate-release capsules and tablets with high content (≥95%) of S. kitaibelii optimized dry extract by direct compression. The influence of ethanol concentration (40–96%, v/v), temperature (25–80 ◦C) and time (2–8 h) on the extraction yield, total phenolic content (TPC), as well as on the contents of rosmarinic acid (RA) and clinopodic acid O (CAO) in the S. kitaibelii dry extract was investigated using the response surface meth-odology (RSM). The estimated optimal conditions for the extraction were: ethanol 46.4%, 61.6 ◦C, 2 h. Dry extract of S. kitaibelii obtained under the optimal conditions (characterized by: yield 24.2%, TPC 170.4 mg gallic acid equivalents/g, RA 10.7 mg/g and CAO 17.1 mg/g) was used to manufacture solid dosage forms. Three... formulations (F) were prepared: F1, hard capsules (99% dry extract, 1% magnesium stearate); F2, uncoated tablets (99% dry extract, 1% magnesium stearate) and F3, uncoated tablets (95% dry extract, 4% sodium starch glycolate, 1% magnesium stearate). Hard capsules (F1) with the uniform weight, adequate disintegration time and dissolution rate were obtained. Regarding tablet formulations, F3 exhibited satisfactory tableting properties, disintegration time and dissolution profile. Therefore, immediate-release capsules and tablets with a high content of S.kitaibelii extract were formulated to accomplish the unmet need for convenient solid dosage forms that contains high doses of herbal extracts.
Ključne reči:
Tableting properties / Direct compression / Disintegration time / Dissolution profile / Herbal preparation / Satureja L.Izvor:
Journal of Drug Delivery Science and Technology, 2021, 66Izdavač:
- Elsevier B.V.
Finansiranje / projekti:
DOI: 10.1016/j.jddst.2021.102776
ISSN: 1773-2247
WoS: 000704538100006
Scopus: 2-s2.0-85114155942
Institucija/grupa
PharmacyTY - JOUR AU - Mudrić, Jelena AU - Arsenijević, Jelena AU - Maksimović, Zoran AU - Ibrić, Svetlana AU - Gopčević, Kristina AU - Đuriš, Jelena PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3953 AB - Aerial parts of Satureja kitaibelii are traditionally used as carminative, for treatment of respiratory and urinary complaints, or as anti-inflammatory agent for skin and mucous membranes. The aim of the present study was to formulate immediate-release capsules and tablets with high content (≥95%) of S. kitaibelii optimized dry extract by direct compression. The influence of ethanol concentration (40–96%, v/v), temperature (25–80 ◦C) and time (2–8 h) on the extraction yield, total phenolic content (TPC), as well as on the contents of rosmarinic acid (RA) and clinopodic acid O (CAO) in the S. kitaibelii dry extract was investigated using the response surface meth-odology (RSM). The estimated optimal conditions for the extraction were: ethanol 46.4%, 61.6 ◦C, 2 h. Dry extract of S. kitaibelii obtained under the optimal conditions (characterized by: yield 24.2%, TPC 170.4 mg gallic acid equivalents/g, RA 10.7 mg/g and CAO 17.1 mg/g) was used to manufacture solid dosage forms. Three formulations (F) were prepared: F1, hard capsules (99% dry extract, 1% magnesium stearate); F2, uncoated tablets (99% dry extract, 1% magnesium stearate) and F3, uncoated tablets (95% dry extract, 4% sodium starch glycolate, 1% magnesium stearate). Hard capsules (F1) with the uniform weight, adequate disintegration time and dissolution rate were obtained. Regarding tablet formulations, F3 exhibited satisfactory tableting properties, disintegration time and dissolution profile. Therefore, immediate-release capsules and tablets with a high content of S.kitaibelii extract were formulated to accomplish the unmet need for convenient solid dosage forms that contains high doses of herbal extracts. PB - Elsevier B.V. T2 - Journal of Drug Delivery Science and Technology T1 - Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii VL - 66 DO - 10.1016/j.jddst.2021.102776 ER -
@article{ author = "Mudrić, Jelena and Arsenijević, Jelena and Maksimović, Zoran and Ibrić, Svetlana and Gopčević, Kristina and Đuriš, Jelena", year = "2021", abstract = "Aerial parts of Satureja kitaibelii are traditionally used as carminative, for treatment of respiratory and urinary complaints, or as anti-inflammatory agent for skin and mucous membranes. The aim of the present study was to formulate immediate-release capsules and tablets with high content (≥95%) of S. kitaibelii optimized dry extract by direct compression. The influence of ethanol concentration (40–96%, v/v), temperature (25–80 ◦C) and time (2–8 h) on the extraction yield, total phenolic content (TPC), as well as on the contents of rosmarinic acid (RA) and clinopodic acid O (CAO) in the S. kitaibelii dry extract was investigated using the response surface meth-odology (RSM). The estimated optimal conditions for the extraction were: ethanol 46.4%, 61.6 ◦C, 2 h. Dry extract of S. kitaibelii obtained under the optimal conditions (characterized by: yield 24.2%, TPC 170.4 mg gallic acid equivalents/g, RA 10.7 mg/g and CAO 17.1 mg/g) was used to manufacture solid dosage forms. Three formulations (F) were prepared: F1, hard capsules (99% dry extract, 1% magnesium stearate); F2, uncoated tablets (99% dry extract, 1% magnesium stearate) and F3, uncoated tablets (95% dry extract, 4% sodium starch glycolate, 1% magnesium stearate). Hard capsules (F1) with the uniform weight, adequate disintegration time and dissolution rate were obtained. Regarding tablet formulations, F3 exhibited satisfactory tableting properties, disintegration time and dissolution profile. Therefore, immediate-release capsules and tablets with a high content of S.kitaibelii extract were formulated to accomplish the unmet need for convenient solid dosage forms that contains high doses of herbal extracts.", publisher = "Elsevier B.V.", journal = "Journal of Drug Delivery Science and Technology", title = "Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii", volume = "66", doi = "10.1016/j.jddst.2021.102776" }
Mudrić, J., Arsenijević, J., Maksimović, Z., Ibrić, S., Gopčević, K.,& Đuriš, J.. (2021). Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii. in Journal of Drug Delivery Science and Technology Elsevier B.V.., 66. https://doi.org/10.1016/j.jddst.2021.102776
Mudrić J, Arsenijević J, Maksimović Z, Ibrić S, Gopčević K, Đuriš J. Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii. in Journal of Drug Delivery Science and Technology. 2021;66. doi:10.1016/j.jddst.2021.102776 .
Mudrić, Jelena, Arsenijević, Jelena, Maksimović, Zoran, Ibrić, Svetlana, Gopčević, Kristina, Đuriš, Jelena, "Tablet and capsule formulations incorporating high doses of a dry optimized herbal extract: The case of Satureja kitaibelii" in Journal of Drug Delivery Science and Technology, 66 (2021), https://doi.org/10.1016/j.jddst.2021.102776 . .