3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction
Autori
Jovanović, MarijaPetrović, Miloš
Cvijić, Sandra
Tomić, Nataša
Stojanović, Dušica
Ibrić, Svetlana
Uskoković, Petar
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioava...ilability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.
Ključne reči:
Buccal films / Gelatin / Propranolol hydrochloride / 3D printing / Physiologically based simulations / Prolonged-release / Semi-solid extrusionIzvor:
Pharmaceutics, 2021, 13, 12Izdavač:
- MDPI
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200135 (Univerzitet u Beogradu, Tehnološko-metalurški fakultet) (RS-MESTD-inst-2020-200135)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200161 (Univerzitet u Beogradu, Farmaceutski fakultet) (RS-MESTD-inst-2020-200161)
DOI: 10.3390/pharmaceutics13122143
ISSN: 1999-4923
WoS: 000736279500001
Scopus: 2-s2.0-85121423156
Institucija/grupa
PharmacyTY - JOUR AU - Jovanović, Marija AU - Petrović, Miloš AU - Cvijić, Sandra AU - Tomić, Nataša AU - Stojanović, Dušica AU - Ibrić, Svetlana AU - Uskoković, Petar PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4016 AB - Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance. PB - MDPI T2 - Pharmaceutics T1 - 3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction VL - 13 IS - 12 DO - 10.3390/pharmaceutics13122143 ER -
@article{ author = "Jovanović, Marija and Petrović, Miloš and Cvijić, Sandra and Tomić, Nataša and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar", year = "2021", abstract = "Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.", publisher = "MDPI", journal = "Pharmaceutics", title = "3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction", volume = "13", number = "12", doi = "10.3390/pharmaceutics13122143" }
Jovanović, M., Petrović, M., Cvijić, S., Tomić, N., Stojanović, D., Ibrić, S.,& Uskoković, P.. (2021). 3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction. in Pharmaceutics MDPI., 13(12). https://doi.org/10.3390/pharmaceutics13122143
Jovanović M, Petrović M, Cvijić S, Tomić N, Stojanović D, Ibrić S, Uskoković P. 3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction. in Pharmaceutics. 2021;13(12). doi:10.3390/pharmaceutics13122143 .
Jovanović, Marija, Petrović, Miloš, Cvijić, Sandra, Tomić, Nataša, Stojanović, Dušica, Ibrić, Svetlana, Uskoković, Petar, "3d printed buccal films for prolonged-release of propranolol hydrochloride: Development, characterization and bioavailability prediction" in Pharmaceutics, 13, no. 12 (2021), https://doi.org/10.3390/pharmaceutics13122143 . .