Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection?
Nivoi kadmijuma u humanom tkivu dojke i nivoi estradiola u serumu: Postoji li veza?
Autori
Anđelković, MilenaKačavenda, Elena
Javorac, Dragana
Antonijević-Miljaković, Evica
Marić, Đurđica
Baralić, Katarina
Đukić-Ćosić, Danijela
Ćurčić, Marijana
Antonijević, Biljana
Bulat, Zorica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Cadmium (Cd), one of the most abundant environmental pollutants, is considered to have endocrine disrupting properties. However, data on the dose-response relationship between Cd dose and levels of hormones have been insufficiently studied, especially in human data sets. Thus, the aim of this study was to determine the possibility of analyzing data obtained from a case- control study in female patients with benign/malignant breast tumors, using the Benchmark dose (BMD) concept. The collected data on Cd levels in breast tissue and estrogen serum levels were processed in PROAST software using different variables. The dose-response relationship between the internal dose of Cd and estradiol levels in the serum was investigated and BMD intervals were calculated. The dose-response relationship between the Cd concentration in breast tissue and the estradiol serum level was shown, indicating lower estradiol serum levels as a consequence of higher Cd concentrations in breast tissue. As one of t...he few studies analyzing human data using the BMD approach, these findings could have a pivotal role in dose response analysis of data collected from human studies.
Kadmijum (Cd), jedan od najzastupljenijih zagađivača životne sredine, dokazan je endokrini ometač. Međutim, podaci o postojanju odnosa između doze Cd i odgovora-nivoa hormona nisu dovoljno istraženi, posebno podaci sakupljeni iz studija na ljudima. Stoga je cilj ove studije bio da se utvrdi mogućnost analize podataka dobijenih iz studije slučaja-kontrole kod pacijentkinja sa benignim/malignim tumorom dojke, primenom koncepta Benčmark doze (BMD). Prikupljeni podaci o nivoima Cd u tkivu dojke i serumskim nivoima estrogena obrađeni su u PROAST softveru uz korišćenje različitih varijabli. Ispitivan je odnos doza-odgovor između unutrašnje doze Cd (koncentracije u tkivu dojke) i estradiola u serumu i izračunati BMD intervali. Utvrđeno je postojanje odnosa između koncentracije Cd u tkivu dojke i nivoa estradiola u serumu koje ukazuje na niže nivoe estradiola u serumu kao posledica veće koncentracije Cd u tkivu dojke. Kao jedno od retkih istraživanja ovog tipa, dobijeni rezultati mogli bi pred...stavljati početak otkrivanja mogućnosti analize podataka prikupljenih u studijama na ljudima primenom BMD pristupa.
Ključne reči:
Cadmium / BMD concept / Endocrine disruption / Human studies / PROAST software / endokrini ometači / kadmijum / BMD koncept / PROAST softver / humane studijeIzvor:
Arhiv za farmaciju, 2021, 71, 6, 581-595Izdavač:
- Pharmaceutical Association of Serbia
Finansiranje / projekti:
- DecodExpo - Decoding the Role of Exposome in Endocrine Health (RS-ScienceFundRS-Promis-6066532)
Institucija/grupa
PharmacyTY - JOUR AU - Anđelković, Milena AU - Kačavenda, Elena AU - Javorac, Dragana AU - Antonijević-Miljaković, Evica AU - Marić, Đurđica AU - Baralić, Katarina AU - Đukić-Ćosić, Danijela AU - Ćurčić, Marijana AU - Antonijević, Biljana AU - Bulat, Zorica PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4074 AB - Cadmium (Cd), one of the most abundant environmental pollutants, is considered to have endocrine disrupting properties. However, data on the dose-response relationship between Cd dose and levels of hormones have been insufficiently studied, especially in human data sets. Thus, the aim of this study was to determine the possibility of analyzing data obtained from a case- control study in female patients with benign/malignant breast tumors, using the Benchmark dose (BMD) concept. The collected data on Cd levels in breast tissue and estrogen serum levels were processed in PROAST software using different variables. The dose-response relationship between the internal dose of Cd and estradiol levels in the serum was investigated and BMD intervals were calculated. The dose-response relationship between the Cd concentration in breast tissue and the estradiol serum level was shown, indicating lower estradiol serum levels as a consequence of higher Cd concentrations in breast tissue. As one of the few studies analyzing human data using the BMD approach, these findings could have a pivotal role in dose response analysis of data collected from human studies. AB - Kadmijum (Cd), jedan od najzastupljenijih zagađivača životne sredine, dokazan je endokrini ometač. Međutim, podaci o postojanju odnosa između doze Cd i odgovora-nivoa hormona nisu dovoljno istraženi, posebno podaci sakupljeni iz studija na ljudima. Stoga je cilj ove studije bio da se utvrdi mogućnost analize podataka dobijenih iz studije slučaja-kontrole kod pacijentkinja sa benignim/malignim tumorom dojke, primenom koncepta Benčmark doze (BMD). Prikupljeni podaci o nivoima Cd u tkivu dojke i serumskim nivoima estrogena obrađeni su u PROAST softveru uz korišćenje različitih varijabli. Ispitivan je odnos doza-odgovor između unutrašnje doze Cd (koncentracije u tkivu dojke) i estradiola u serumu i izračunati BMD intervali. Utvrđeno je postojanje odnosa između koncentracije Cd u tkivu dojke i nivoa estradiola u serumu koje ukazuje na niže nivoe estradiola u serumu kao posledica veće koncentracije Cd u tkivu dojke. Kao jedno od retkih istraživanja ovog tipa, dobijeni rezultati mogli bi predstavljati početak otkrivanja mogućnosti analize podataka prikupljenih u studijama na ljudima primenom BMD pristupa. PB - Pharmaceutical Association of Serbia T2 - Arhiv za farmaciju T1 - Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection? T1 - Nivoi kadmijuma u humanom tkivu dojke i nivoi estradiola u serumu: Postoji li veza? VL - 71 IS - 6 SP - 581 EP - 595 DO - 10.5937/ARHFARM71-34280 ER -
@article{ author = "Anđelković, Milena and Kačavenda, Elena and Javorac, Dragana and Antonijević-Miljaković, Evica and Marić, Đurđica and Baralić, Katarina and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica", year = "2021", abstract = "Cadmium (Cd), one of the most abundant environmental pollutants, is considered to have endocrine disrupting properties. However, data on the dose-response relationship between Cd dose and levels of hormones have been insufficiently studied, especially in human data sets. Thus, the aim of this study was to determine the possibility of analyzing data obtained from a case- control study in female patients with benign/malignant breast tumors, using the Benchmark dose (BMD) concept. The collected data on Cd levels in breast tissue and estrogen serum levels were processed in PROAST software using different variables. The dose-response relationship between the internal dose of Cd and estradiol levels in the serum was investigated and BMD intervals were calculated. The dose-response relationship between the Cd concentration in breast tissue and the estradiol serum level was shown, indicating lower estradiol serum levels as a consequence of higher Cd concentrations in breast tissue. As one of the few studies analyzing human data using the BMD approach, these findings could have a pivotal role in dose response analysis of data collected from human studies., Kadmijum (Cd), jedan od najzastupljenijih zagađivača životne sredine, dokazan je endokrini ometač. Međutim, podaci o postojanju odnosa između doze Cd i odgovora-nivoa hormona nisu dovoljno istraženi, posebno podaci sakupljeni iz studija na ljudima. Stoga je cilj ove studije bio da se utvrdi mogućnost analize podataka dobijenih iz studije slučaja-kontrole kod pacijentkinja sa benignim/malignim tumorom dojke, primenom koncepta Benčmark doze (BMD). Prikupljeni podaci o nivoima Cd u tkivu dojke i serumskim nivoima estrogena obrađeni su u PROAST softveru uz korišćenje različitih varijabli. Ispitivan je odnos doza-odgovor između unutrašnje doze Cd (koncentracije u tkivu dojke) i estradiola u serumu i izračunati BMD intervali. Utvrđeno je postojanje odnosa između koncentracije Cd u tkivu dojke i nivoa estradiola u serumu koje ukazuje na niže nivoe estradiola u serumu kao posledica veće koncentracije Cd u tkivu dojke. Kao jedno od retkih istraživanja ovog tipa, dobijeni rezultati mogli bi predstavljati početak otkrivanja mogućnosti analize podataka prikupljenih u studijama na ljudima primenom BMD pristupa.", publisher = "Pharmaceutical Association of Serbia", journal = "Arhiv za farmaciju", title = "Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection?, Nivoi kadmijuma u humanom tkivu dojke i nivoi estradiola u serumu: Postoji li veza?", volume = "71", number = "6", pages = "581-595", doi = "10.5937/ARHFARM71-34280" }
Anđelković, M., Kačavenda, E., Javorac, D., Antonijević-Miljaković, E., Marić, Đ., Baralić, K., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2021). Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection?. in Arhiv za farmaciju Pharmaceutical Association of Serbia., 71(6), 581-595. https://doi.org/10.5937/ARHFARM71-34280
Anđelković M, Kačavenda E, Javorac D, Antonijević-Miljaković E, Marić Đ, Baralić K, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection?. in Arhiv za farmaciju. 2021;71(6):581-595. doi:10.5937/ARHFARM71-34280 .
Anđelković, Milena, Kačavenda, Elena, Javorac, Dragana, Antonijević-Miljaković, Evica, Marić, Đurđica, Baralić, Katarina, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection?" in Arhiv za farmaciju, 71, no. 6 (2021):581-595, https://doi.org/10.5937/ARHFARM71-34280 . .