Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats
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2003
Authors
Petrović, SilvanaDobrić, Silva
Bokonjić, Dubravko
Niketić, Marjan
Garcia-Pineres, A
Merfort, I
Article (Published version)
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Oral administration of the chloroform extract from Tanacetum larvatum (Griseb. ex Pant.) Kanitz caused a dose-dependent anti-inflammatory effect in the carrageenan-induced rat paw oedema test. The obtained anti-inflammatory effect was 8.6, 32.8, 37.0 and 49.5% for the extract doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 50 mg/kg. Indomethacin had a strong anti-inflammatory effect of 73.4% at a dose of 8 mg/kg, but large gastric lesions were detected. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the anti-inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The anti-inflammatory and anti-ulcer activity may be mainly due to the inhibition of DNA binding of the transcription factor NF-kappaB by components of the plant extract. This was proven in an electrophoretic mobility shift assay at a concentration of 50 mug/ml. Due to its anti-inflamm...atory as well as anti-ulcer effects, Tanacetum larvatum should especially be used combined with those drugs that are known both for their strong anti-inflammatory activities and the ulcerogenic side effects such as NSAIDs.
Keywords:
Tanacetum larvatum extract / anti-inflammatory / gastric anti-ulcer / NF-kappa BSource:
Journal of Ethnopharmacology, 2003, 87, 1, 109-113Publisher:
- Elsevier Ireland Ltd, Clare
DOI: 10.1016/S0378-8741(03)00118-1
ISSN: 0378-8741
PubMed: 12787963
WoS: 000183590200018
Scopus: 2-s2.0-0038350856
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PharmacyTY - JOUR AU - Petrović, Silvana AU - Dobrić, Silva AU - Bokonjić, Dubravko AU - Niketić, Marjan AU - Garcia-Pineres, A AU - Merfort, I PY - 2003 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/443 AB - Oral administration of the chloroform extract from Tanacetum larvatum (Griseb. ex Pant.) Kanitz caused a dose-dependent anti-inflammatory effect in the carrageenan-induced rat paw oedema test. The obtained anti-inflammatory effect was 8.6, 32.8, 37.0 and 49.5% for the extract doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 50 mg/kg. Indomethacin had a strong anti-inflammatory effect of 73.4% at a dose of 8 mg/kg, but large gastric lesions were detected. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the anti-inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The anti-inflammatory and anti-ulcer activity may be mainly due to the inhibition of DNA binding of the transcription factor NF-kappaB by components of the plant extract. This was proven in an electrophoretic mobility shift assay at a concentration of 50 mug/ml. Due to its anti-inflammatory as well as anti-ulcer effects, Tanacetum larvatum should especially be used combined with those drugs that are known both for their strong anti-inflammatory activities and the ulcerogenic side effects such as NSAIDs. PB - Elsevier Ireland Ltd, Clare T2 - Journal of Ethnopharmacology T1 - Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats VL - 87 IS - 1 SP - 109 EP - 113 DO - 10.1016/S0378-8741(03)00118-1 ER -
@article{ author = "Petrović, Silvana and Dobrić, Silva and Bokonjić, Dubravko and Niketić, Marjan and Garcia-Pineres, A and Merfort, I", year = "2003", abstract = "Oral administration of the chloroform extract from Tanacetum larvatum (Griseb. ex Pant.) Kanitz caused a dose-dependent anti-inflammatory effect in the carrageenan-induced rat paw oedema test. The obtained anti-inflammatory effect was 8.6, 32.8, 37.0 and 49.5% for the extract doses of 25, 50, 100 and 200 mg/kg, respectively, being statistically significant at a dose of 50 mg/kg. Indomethacin had a strong anti-inflammatory effect of 73.4% at a dose of 8 mg/kg, but large gastric lesions were detected. When the plant extract in the highest tested dose (200 mg/kg) was concomitantly given with indomethacin, the anti-inflammatory effect was slightly enhanced, but the gastric lesions were significantly reduced. The anti-inflammatory and anti-ulcer activity may be mainly due to the inhibition of DNA binding of the transcription factor NF-kappaB by components of the plant extract. This was proven in an electrophoretic mobility shift assay at a concentration of 50 mug/ml. Due to its anti-inflammatory as well as anti-ulcer effects, Tanacetum larvatum should especially be used combined with those drugs that are known both for their strong anti-inflammatory activities and the ulcerogenic side effects such as NSAIDs.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Journal of Ethnopharmacology", title = "Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats", volume = "87", number = "1", pages = "109-113", doi = "10.1016/S0378-8741(03)00118-1" }
Petrović, S., Dobrić, S., Bokonjić, D., Niketić, M., Garcia-Pineres, A.,& Merfort, I.. (2003). Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats. in Journal of Ethnopharmacology Elsevier Ireland Ltd, Clare., 87(1), 109-113. https://doi.org/10.1016/S0378-8741(03)00118-1
Petrović S, Dobrić S, Bokonjić D, Niketić M, Garcia-Pineres A, Merfort I. Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats. in Journal of Ethnopharmacology. 2003;87(1):109-113. doi:10.1016/S0378-8741(03)00118-1 .
Petrović, Silvana, Dobrić, Silva, Bokonjić, Dubravko, Niketić, Marjan, Garcia-Pineres, A, Merfort, I, "Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats" in Journal of Ethnopharmacology, 87, no. 1 (2003):109-113, https://doi.org/10.1016/S0378-8741(03)00118-1 . .