Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories
Abstract
In this paper the second-derivative spectrophotometric method for the simultaneous determination of lidocaine (CAS 137-58-6) and hydrocortisone acetate (CAS 50-03-3) in suppositories is described. One suppository contains 60 mg of lidocaine and 5 mg of hydrocortisone acetate. Optimal conditions for the quantitative analysis were settled. The second-derivative spectra were recorded in the range from 210 to 380 nm against methanol. Determination of lidocaine was performed at 256.0 nm and hydrocortisone acetate at 260.5 nm, using the "zero crossing" method. The results obtained show that there was no interference of ingredients matrix under the mentioned experimental conditions. The method is simple, rapid and precise and can be used in a routine analysis of such pharmaceutical dosage forms.
Keywords:
CAS 50-03-3 / CAS 137-58-6 / hydrocortisone acetate / lidocaine / second-derivative spectrophotometry / zero-crossing methodSource:
Pharmazeutische Industrie, 2004, 66, 3, 330-333Publisher:
- ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
Collections
Institution/Community
PharmacyTY - JOUR AU - Medenica, Mirjana AU - Ivanović, D AU - Marković, S AU - Malenović, Anđelija AU - Jančić, Biljana PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/487 AB - In this paper the second-derivative spectrophotometric method for the simultaneous determination of lidocaine (CAS 137-58-6) and hydrocortisone acetate (CAS 50-03-3) in suppositories is described. One suppository contains 60 mg of lidocaine and 5 mg of hydrocortisone acetate. Optimal conditions for the quantitative analysis were settled. The second-derivative spectra were recorded in the range from 210 to 380 nm against methanol. Determination of lidocaine was performed at 256.0 nm and hydrocortisone acetate at 260.5 nm, using the "zero crossing" method. The results obtained show that there was no interference of ingredients matrix under the mentioned experimental conditions. The method is simple, rapid and precise and can be used in a routine analysis of such pharmaceutical dosage forms. PB - ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf T2 - Pharmazeutische Industrie T1 - Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories VL - 66 IS - 3 SP - 330 EP - 333 UR - https://hdl.handle.net/21.15107/rcub_farfar_487 ER -
@article{ author = "Medenica, Mirjana and Ivanović, D and Marković, S and Malenović, Anđelija and Jančić, Biljana", year = "2004", abstract = "In this paper the second-derivative spectrophotometric method for the simultaneous determination of lidocaine (CAS 137-58-6) and hydrocortisone acetate (CAS 50-03-3) in suppositories is described. One suppository contains 60 mg of lidocaine and 5 mg of hydrocortisone acetate. Optimal conditions for the quantitative analysis were settled. The second-derivative spectra were recorded in the range from 210 to 380 nm against methanol. Determination of lidocaine was performed at 256.0 nm and hydrocortisone acetate at 260.5 nm, using the "zero crossing" method. The results obtained show that there was no interference of ingredients matrix under the mentioned experimental conditions. The method is simple, rapid and precise and can be used in a routine analysis of such pharmaceutical dosage forms.", publisher = "ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf", journal = "Pharmazeutische Industrie", title = "Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories", volume = "66", number = "3", pages = "330-333", url = "https://hdl.handle.net/21.15107/rcub_farfar_487" }
Medenica, M., Ivanović, D., Marković, S., Malenović, A.,& Jančić, B.. (2004). Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories. in Pharmazeutische Industrie ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf., 66(3), 330-333. https://hdl.handle.net/21.15107/rcub_farfar_487
Medenica M, Ivanović D, Marković S, Malenović A, Jančić B. Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories. in Pharmazeutische Industrie. 2004;66(3):330-333. https://hdl.handle.net/21.15107/rcub_farfar_487 .
Medenica, Mirjana, Ivanović, D, Marković, S, Malenović, Anđelija, Jančić, Biljana, "Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories" in Pharmazeutische Industrie, 66, no. 3 (2004):330-333, https://hdl.handle.net/21.15107/rcub_farfar_487 .