Micro- and nanoscale drug delivery systems based on xanthan gum hydrogels
Само за регистроване кориснике
2022
Поглавље у монографији (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Xanthan gum (XG) is a highly purified anionic polysaccharide produced by the bacteria Xanthomonas campestris during the aerobic fermentation of glucose, sucrose, or some complex substrates. It is a widely used, relatively inexpensive, nontoxic, biodegradable and bioadhesive pharmaceutical excipient. Moreover, the properties of XG in aqueous solutions, reflected in the stability of the ionized form in a wide range of pH, temperature, and concentration of dissolved salts, as well as the possibility of chemical modification (grafting), make it suitable for forming various biocompatible homopolymer and heteropolymer hydrogels based on physical interactions or chemical cross-linking. XG-based hydrogels are promising microscale and nanoscale carriers that can be administered as solid, semisolid, and liquid dosage forms by a variety of routes of administration, such as oral, (trans)dermal, parenteral, ocular, nasal, and rectal. Of particular importance is the combining of XG or corresponding ...chemical derivatives with other natural, semisynthetic, and synthetic polymers, to achieve optimal rheological and thermal properties, swelling capacity in aqueous media, pH-sensitivity, thermosensitivity, redox-sensitivity, and electrosensitivity of the hydrogel carriers, and thus to control and target drug delivery. Recent studies have demonstrated the possibility of obtaining nanocomposite hydrogels by forming hybrids of XG-based hydrogels and nanomaterials (nanoparticles, microemulsions, and nanoemulsions) that have shown superior stability and drug delivery performances compared to starting components. Selected examples of carriers based on XG hydrogels are commented on in this chapter, with special reference to their preparation/synthesis, physicochemical characteristics and capacity to deliver drugs with poor solubility, permeability through biological barriers, stability, and/or toxicological profile.
Кључне речи:
Controlled drug release / Drug delivery system / Hydrogel / Materials structure / Microcarrier / Nanocarrier / Xanthan gumИзвор:
Micro- and Nanoengineered Gum-Based Biomaterials for Drug Delivery and Biomedical Applications, 2022, 35-76Издавач:
- Elsevier Inc.
DOI: 10.1016/B978-0-323-90986-0.00007-8
ISBN: 978-0-323-90986-0
Scopus: 2-s2.0-85128324546
Институција/група
PharmacyTY - CHAP AU - Đekić, Ljiljana AU - Ćirić, Ana PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5373 AB - Xanthan gum (XG) is a highly purified anionic polysaccharide produced by the bacteria Xanthomonas campestris during the aerobic fermentation of glucose, sucrose, or some complex substrates. It is a widely used, relatively inexpensive, nontoxic, biodegradable and bioadhesive pharmaceutical excipient. Moreover, the properties of XG in aqueous solutions, reflected in the stability of the ionized form in a wide range of pH, temperature, and concentration of dissolved salts, as well as the possibility of chemical modification (grafting), make it suitable for forming various biocompatible homopolymer and heteropolymer hydrogels based on physical interactions or chemical cross-linking. XG-based hydrogels are promising microscale and nanoscale carriers that can be administered as solid, semisolid, and liquid dosage forms by a variety of routes of administration, such as oral, (trans)dermal, parenteral, ocular, nasal, and rectal. Of particular importance is the combining of XG or corresponding chemical derivatives with other natural, semisynthetic, and synthetic polymers, to achieve optimal rheological and thermal properties, swelling capacity in aqueous media, pH-sensitivity, thermosensitivity, redox-sensitivity, and electrosensitivity of the hydrogel carriers, and thus to control and target drug delivery. Recent studies have demonstrated the possibility of obtaining nanocomposite hydrogels by forming hybrids of XG-based hydrogels and nanomaterials (nanoparticles, microemulsions, and nanoemulsions) that have shown superior stability and drug delivery performances compared to starting components. Selected examples of carriers based on XG hydrogels are commented on in this chapter, with special reference to their preparation/synthesis, physicochemical characteristics and capacity to deliver drugs with poor solubility, permeability through biological barriers, stability, and/or toxicological profile. PB - Elsevier Inc. T2 - Micro- and Nanoengineered Gum-Based Biomaterials for Drug Delivery and Biomedical Applications T1 - Micro- and nanoscale drug delivery systems based on xanthan gum hydrogels SP - 35 EP - 76 DO - 10.1016/B978-0-323-90986-0.00007-8 ER -
@inbook{ author = "Đekić, Ljiljana and Ćirić, Ana", year = "2022", abstract = "Xanthan gum (XG) is a highly purified anionic polysaccharide produced by the bacteria Xanthomonas campestris during the aerobic fermentation of glucose, sucrose, or some complex substrates. It is a widely used, relatively inexpensive, nontoxic, biodegradable and bioadhesive pharmaceutical excipient. Moreover, the properties of XG in aqueous solutions, reflected in the stability of the ionized form in a wide range of pH, temperature, and concentration of dissolved salts, as well as the possibility of chemical modification (grafting), make it suitable for forming various biocompatible homopolymer and heteropolymer hydrogels based on physical interactions or chemical cross-linking. XG-based hydrogels are promising microscale and nanoscale carriers that can be administered as solid, semisolid, and liquid dosage forms by a variety of routes of administration, such as oral, (trans)dermal, parenteral, ocular, nasal, and rectal. Of particular importance is the combining of XG or corresponding chemical derivatives with other natural, semisynthetic, and synthetic polymers, to achieve optimal rheological and thermal properties, swelling capacity in aqueous media, pH-sensitivity, thermosensitivity, redox-sensitivity, and electrosensitivity of the hydrogel carriers, and thus to control and target drug delivery. Recent studies have demonstrated the possibility of obtaining nanocomposite hydrogels by forming hybrids of XG-based hydrogels and nanomaterials (nanoparticles, microemulsions, and nanoemulsions) that have shown superior stability and drug delivery performances compared to starting components. Selected examples of carriers based on XG hydrogels are commented on in this chapter, with special reference to their preparation/synthesis, physicochemical characteristics and capacity to deliver drugs with poor solubility, permeability through biological barriers, stability, and/or toxicological profile.", publisher = "Elsevier Inc.", journal = "Micro- and Nanoengineered Gum-Based Biomaterials for Drug Delivery and Biomedical Applications", booktitle = "Micro- and nanoscale drug delivery systems based on xanthan gum hydrogels", pages = "35-76", doi = "10.1016/B978-0-323-90986-0.00007-8" }
Đekić, L.,& Ćirić, A.. (2022). Micro- and nanoscale drug delivery systems based on xanthan gum hydrogels. in Micro- and Nanoengineered Gum-Based Biomaterials for Drug Delivery and Biomedical Applications Elsevier Inc.., 35-76. https://doi.org/10.1016/B978-0-323-90986-0.00007-8
Đekić L, Ćirić A. Micro- and nanoscale drug delivery systems based on xanthan gum hydrogels. in Micro- and Nanoengineered Gum-Based Biomaterials for Drug Delivery and Biomedical Applications. 2022;:35-76. doi:10.1016/B978-0-323-90986-0.00007-8 .
Đekić, Ljiljana, Ćirić, Ana, "Micro- and nanoscale drug delivery systems based on xanthan gum hydrogels" in Micro- and Nanoengineered Gum-Based Biomaterials for Drug Delivery and Biomedical Applications (2022):35-76, https://doi.org/10.1016/B978-0-323-90986-0.00007-8 . .