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Cu(II) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach
dc.creator | Selaković, Snežana | |
dc.creator | Rodić, Marko | |
dc.creator | Novaković, Irena | |
dc.creator | Matić, Ivana | |
dc.creator | Stanojković, Tatjana | |
dc.creator | Pirković, Andrea | |
dc.creator | Živković, Lada | |
dc.creator | Spremo-Potparević, Biljana | |
dc.creator | Milčić, Vesna | |
dc.creator | Dimiza, Filitsa | |
dc.creator | Psomas, George | |
dc.creator | Anđelković, Katarina | |
dc.creator | Šumar-Ristović, Maja | |
dc.date.accessioned | 2024-01-30T12:34:10Z | |
dc.date.available | 2024-01-30T12:34:10Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 1477-9226 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/5522 | |
dc.description.abstract | Copper(ii) complexes with an α-diimine show a wide variety of biological activities, such as antibacterial, antifungal, antioxidant and anticancer. In this work, we synthesized and structurally characterized two novel Cu(ii) complexes with methyl 3-formyl-4-hydroxybenzoate (HL) and α-diimines: 2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen). Crystal structure analysis shows that the formulas of the compounds are [Cu(bipy)(L)(BF4)] (1) and [Cu(phen)(L)(H2O)](BF4)·H2O (2), with BF4− as a ligand in complex 1, which is rarely coordinated to metals. Both complexes have a square pyramidal geometry, while DFT calculations showed that the most stable structures of complexes 1 and 2 in a water/DMSO mixture are square-planar derivatives [Cu(bipy)(L)]+ and [Cu(phen)(L)]+. The antibacterial activity of compounds was evaluated in vitro on four Gram-negative and four Gram-positive bacterial strains. Complex 2 showed greater antibacterial activity towards all bacterial strains comparable to the control compound Amikacin. Complex 2 exerted a strong cytotoxic effect against the tested cancer cell lines (IC50 values ranging from 0.32 to 0.44 μM). Both complexes caused apoptotic cell death in HeLa cells and a noticeable in vitro antiangiogenic effect. In the concentration range of 5 to 100 μM, the complexes showed the absence of a genotoxic effect and displayed a protective effect against oxidative DNA damage induced by H2O2 in human peripheral blood cells. The interaction between the compounds and calf-thymus DNA was evaluated by diverse techniques suggesting a tight binding, which was also confirmed by molecular docking. In addition, it was found that the complexes bind tightly and reversibly to bovine and human serum albumin. | |
dc.publisher | Royal Society of Chemistry | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.relation | "info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200125/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200043/RS// | |
dc.rights | restrictedAccess | |
dc.source | Dalton Transactions | |
dc.title | Cu(II) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach | |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.volume | 53 | |
dc.citation.issue | 6 | |
dc.citation.spage | 2770 | |
dc.citation.epage | 2788 | |
dc.identifier.wos | 001143573200001 | |
dc.identifier.doi | 10.1039/d3dt03862a | |
dc.identifier.pmid | 38226867 | |
dc.identifier.scopus | 2-s2.0-85182874933 | |
dc.type.version | publishedVersion |