Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector
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2005
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Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.
Ključne reči:
TLC / chiral separation / metoprolol tartrate / D-(-)-tartaric acidIzvor:
Journal of Planar Chromatography - Modern TLC, 2005, 18, 104, 294-299Izdavač:
- Research Inst Medicinal Plants, Budakalasz
DOI: 10.1556/JPC.18.2005.4.8
ISSN: 0933-4173
WoS: 000231689200008
Scopus: 2-s2.0-24344454332
Institucija/grupa
PharmacyTY - JOUR AU - Lučić, Branka AU - Radulović, Dušanka AU - Vujić, Zorica AU - Agbaba, Danica PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/570 AB - A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C. PB - Research Inst Medicinal Plants, Budakalasz T2 - Journal of Planar Chromatography - Modern TLC T1 - Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector VL - 18 IS - 104 SP - 294 EP - 299 DO - 10.1556/JPC.18.2005.4.8 ER -
@article{ author = "Lučić, Branka and Radulović, Dušanka and Vujić, Zorica and Agbaba, Danica", year = "2005", abstract = "A method for chromatographic separation of the enantiomers of (+/-)-metoprolol tartrate (+/- MeT) employing a chiral mobile phase additive (CMPA) is described. By using silica gel plates previously impregnated with the mobile phase (ethanol-water, 70 + 30, v/v) containing D-(-)-tartaric acid as chiral selector, direct separation of the enantiomers of +/- MeT was achieved. The results of experiments with different concentrations of D-(-)-tartaric acid (5.8, 11.6, and 23 mmol L-1) revealed that the best resolution of the enantiomers of +/- MeT was achieved with 11.6 mm D-(-)-tartaric acid in both the mobile phase and the impregnation solution, at 25 2 degrees C.", publisher = "Research Inst Medicinal Plants, Budakalasz", journal = "Journal of Planar Chromatography - Modern TLC", title = "Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector", volume = "18", number = "104", pages = "294-299", doi = "10.1556/JPC.18.2005.4.8" }
Lučić, B., Radulović, D., Vujić, Z.,& Agbaba, D.. (2005). Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector. in Journal of Planar Chromatography - Modern TLC Research Inst Medicinal Plants, Budakalasz., 18(104), 294-299. https://doi.org/10.1556/JPC.18.2005.4.8
Lučić B, Radulović D, Vujić Z, Agbaba D. Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector. in Journal of Planar Chromatography - Modern TLC. 2005;18(104):294-299. doi:10.1556/JPC.18.2005.4.8 .
Lučić, Branka, Radulović, Dušanka, Vujić, Zorica, Agbaba, Danica, "Direct separation of the enantiomers of (+/-)-metoprolol tartrate on impregnated TLC plates with D-(-)-tartaric acid as a chiral selector" in Journal of Planar Chromatography - Modern TLC, 18, no. 104 (2005):294-299, https://doi.org/10.1556/JPC.18.2005.4.8 . .