Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide
Само за регистроване кориснике
2005
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(...4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3).
Кључне речи:
hydrochlorothiazide / CTAB / micelles / binding constant / partition coefficientИзвор:
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2005, 256, 2-3, 225-232Издавач:
- Elsevier Science BV, Amsterdam
DOI: 10.1016/j.colsurfa.2005.01.023
ISSN: 0927-7757
WoS: 000228322800018
Scopus: 2-s2.0-14844300859
Институција/група
PharmacyTY - JOUR AU - Čudina, Olivera AU - Karljiković-Rajić, Katarina AU - Ruvarac-Bugarcić, I AU - Janković, I PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/592 AB - In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3). PB - Elsevier Science BV, Amsterdam T2 - Colloids and Surfaces A: Physicochemical and Engineering Aspects T1 - Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide VL - 256 IS - 2-3 SP - 225 EP - 232 DO - 10.1016/j.colsurfa.2005.01.023 ER -
@article{ author = "Čudina, Olivera and Karljiković-Rajić, Katarina and Ruvarac-Bugarcić, I and Janković, I", year = "2005", abstract = "In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3).", publisher = "Elsevier Science BV, Amsterdam", journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects", title = "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide", volume = "256", number = "2-3", pages = "225-232", doi = "10.1016/j.colsurfa.2005.01.023" }
Čudina, O., Karljiković-Rajić, K., Ruvarac-Bugarcić, I.,& Janković, I.. (2005). Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces A: Physicochemical and Engineering Aspects Elsevier Science BV, Amsterdam., 256(2-3), 225-232. https://doi.org/10.1016/j.colsurfa.2005.01.023
Čudina O, Karljiković-Rajić K, Ruvarac-Bugarcić I, Janković I. Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2005;256(2-3):225-232. doi:10.1016/j.colsurfa.2005.01.023 .
Čudina, Olivera, Karljiković-Rajić, Katarina, Ruvarac-Bugarcić, I, Janković, I, "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide" in Colloids and Surfaces A: Physicochemical and Engineering Aspects, 256, no. 2-3 (2005):225-232, https://doi.org/10.1016/j.colsurfa.2005.01.023 . .