Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis
Apstrakt
Experimental autoimmune myasthenia gravis (EAMG) was induced in female AO rats, by a single immunization with Torpedo acetylcholine receptor (AChR). Animals injected with saline served as controls. The study showed substantial changes in EAMG rats in the thymopoiesis, causing an increase in the relative proportion of mature CD8+ and, particularly, CD4+ (possibly autoreactive) single positive (SP) cells expressing TCR alpha beta at high level (TCR alpha beta(high)), as well as in that of mature double negative (DN) TCR alpha beta(high) cells, which are believed to be the immunoregulatory cells that augment autoantibody (autoAb) production. These results indicate that an augmented production of autoreactive CD4+ cells, on one side, and an increase of the immunoregulatory T cells that augment autoAb production, on the other side (reflecting, most likely, an increased entry of activated autoreactive CD4+ T cells from the periphery into the thymus), may have a significant role in the susten...tion of immune response in EAMG, and may suggest a putative mechanism underlying the sustention of autoimmune response in acquired MG.
Ključne reči:
experimental autoimmune myasthenia gravis / morphometry / T-cell maturation / thymusIzvor:
International Journal of Neuroscience, 2005, 115, 4, 461-477Izdavač:
- Taylor & Francis Ltd, Abingdon
DOI: 10.1080/00207450590522464
ISSN: 0020-7454
PubMed: 15809214
WoS: 000227878100003
Scopus: 2-s2.0-16244396087
Institucija/grupa
PharmacyTY - JOUR AU - Kosec, Duško AU - Vidić-Danković, Biljana AU - Isaković, K AU - Leposavić, Gordana PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/593 AB - Experimental autoimmune myasthenia gravis (EAMG) was induced in female AO rats, by a single immunization with Torpedo acetylcholine receptor (AChR). Animals injected with saline served as controls. The study showed substantial changes in EAMG rats in the thymopoiesis, causing an increase in the relative proportion of mature CD8+ and, particularly, CD4+ (possibly autoreactive) single positive (SP) cells expressing TCR alpha beta at high level (TCR alpha beta(high)), as well as in that of mature double negative (DN) TCR alpha beta(high) cells, which are believed to be the immunoregulatory cells that augment autoantibody (autoAb) production. These results indicate that an augmented production of autoreactive CD4+ cells, on one side, and an increase of the immunoregulatory T cells that augment autoAb production, on the other side (reflecting, most likely, an increased entry of activated autoreactive CD4+ T cells from the periphery into the thymus), may have a significant role in the sustention of immune response in EAMG, and may suggest a putative mechanism underlying the sustention of autoimmune response in acquired MG. PB - Taylor & Francis Ltd, Abingdon T2 - International Journal of Neuroscience T1 - Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis VL - 115 IS - 4 SP - 461 EP - 477 DO - 10.1080/00207450590522464 ER -
@article{ author = "Kosec, Duško and Vidić-Danković, Biljana and Isaković, K and Leposavić, Gordana", year = "2005", abstract = "Experimental autoimmune myasthenia gravis (EAMG) was induced in female AO rats, by a single immunization with Torpedo acetylcholine receptor (AChR). Animals injected with saline served as controls. The study showed substantial changes in EAMG rats in the thymopoiesis, causing an increase in the relative proportion of mature CD8+ and, particularly, CD4+ (possibly autoreactive) single positive (SP) cells expressing TCR alpha beta at high level (TCR alpha beta(high)), as well as in that of mature double negative (DN) TCR alpha beta(high) cells, which are believed to be the immunoregulatory cells that augment autoantibody (autoAb) production. These results indicate that an augmented production of autoreactive CD4+ cells, on one side, and an increase of the immunoregulatory T cells that augment autoAb production, on the other side (reflecting, most likely, an increased entry of activated autoreactive CD4+ T cells from the periphery into the thymus), may have a significant role in the sustention of immune response in EAMG, and may suggest a putative mechanism underlying the sustention of autoimmune response in acquired MG.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "International Journal of Neuroscience", title = "Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis", volume = "115", number = "4", pages = "461-477", doi = "10.1080/00207450590522464" }
Kosec, D., Vidić-Danković, B., Isaković, K.,& Leposavić, G.. (2005). Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis. in International Journal of Neuroscience Taylor & Francis Ltd, Abingdon., 115(4), 461-477. https://doi.org/10.1080/00207450590522464
Kosec D, Vidić-Danković B, Isaković K, Leposavić G. Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis. in International Journal of Neuroscience. 2005;115(4):461-477. doi:10.1080/00207450590522464 .
Kosec, Duško, Vidić-Danković, Biljana, Isaković, K, Leposavić, Gordana, "Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis" in International Journal of Neuroscience, 115, no. 4 (2005):461-477, https://doi.org/10.1080/00207450590522464 . .