Pharmaceutical-technological aspects of drugs in inhalation therapy of asthma in children population
Farmaceutsko-tehnološki aspekti lekova u inhalacionoj terapiji astme u dece
Abstract
Inhalation is the preferred route for asthma therapy, since it offers a rapid onset of drug action, requires smaller doses, and reduces systemic effects compared with other routes of administration. Unfortunately, inhalation devices are frequently used in an empirical manner rather than on evidence-based awareness. Metered-dose inhalers (MDI) are practical, cheap and multidose. However, there are several problems with their use. Breath-actuated MDI are easy to use and can be activated by very low flow. However, young children may not be able to use them efficiently. The use of spacers reduces oropharyngeal deposition and improves drug delivery to the lung. Spacers do not require patient coordination, but some general rules must be followed for their optimal use. Dry powder inhalers (DPI) are portable and easy to use. They are indicated either for rescue bronchodilators therapy or for regular treatment with inhaled corticosteroids and long-acting bronchodilators. For the application of ...liquid preparation for inhalation a wide variety of nebulizers are available in asthma therapy. The choice of a delivery device mainly depends on the age of the patient, the drug to be administered and the condition to be treated. As the therapy efficacy mainly depends on drug device optimal use, proper education of pharmacist and his rediness/duty to demonstrate the device usage is also essential for children and parents, too.
Budući da ima niz prednosti, inhalacioni put primene lekova je prvi izbor u terapiji hronične astme: brz početak delovanja leka, a potrebne su niže doze i time manja mogućnost ispoljavanja neželjenih efekata u poređenju sa dragim putevima primene. Nažalost, pomoćni uređaji za inhalaciju češće se koriste empirijski nego na osnovu kliničkih dokaza. Merno-dozni inhalatori (MDI), sprejovi za inhalaciju su još uvek široko rasprostranjen vid inhalacione primene lekova u terapiji astme. Praktični su, jevtini i višedozni sistemi. Međutim, postoji nekoliko problema vezano za njihovu primenu. Udahom-aktivirani MDI su jednostavni za primenu i mogu se aktivirati pri veoma slabom udanu. Nažalost, mala deca ih ne mogu koristiti efikasno. Upotrebom komora redukuje se deponovanje lekova u orofarinksu i poboljšava raspodela leka u pluća. Komore ne zahtevaju koordinaciju pokreta na relaciji raspršivanje/inhalacija od strane pacijenta, ali se neka generalna pravila moraju poštovati u cilju postizanja oče...kivanog terapijskog odgovora. Praškovi za inhalaciju (DPI) su laki za primenu i prihvatljive su veličine. Indikovani su u akutnim stanjima za primenu bronhodilatatora ili za terapiju održavanja kod hronične astme, koja se tretira kortikosteroidima ili dugo-delujućim bronhodilatatorima. U terapiji astme na raspolaganju je nekoliko tipova nebulizera za primenu tečnih preparata za inhalaciju. Izbor optimalnog uređaja uglavnom zavisi od uzrasta deteta, leka koji treba da se primeni i stanja koje treba tretirati. Budući da efekat terapije u velikoj meri zavisi od načina upotrebe uređaja za inhalaciju, adekvatna edukacija farmaceuta i njegova obučenost i spremnost/obaveza da pacijentu demonstrira primenu preparata je od izuzetne važnosti i za decu i za roditelje.
Keywords:
asthma / bronchodilators / corticosteroid / inhalation / spacer / nebulizer / education / metered-dose inhalers / dry powder inhalers / astma / bronhodilatatori / kortikosteroidi / komora / nebulizer / edukacija / inhalacija merho-dozni inhalator / prašak za inhalacijuSource:
Arhiv za farmaciju, 2005, 55, 4, 389-409Publisher:
- Savez farmaceutskih udruženja Srbije, Beograd
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PharmacyTY - JOUR AU - Savić, Snežana AU - Savić, Miroslav AU - Vuleta, Gordana PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/607 AB - Inhalation is the preferred route for asthma therapy, since it offers a rapid onset of drug action, requires smaller doses, and reduces systemic effects compared with other routes of administration. Unfortunately, inhalation devices are frequently used in an empirical manner rather than on evidence-based awareness. Metered-dose inhalers (MDI) are practical, cheap and multidose. However, there are several problems with their use. Breath-actuated MDI are easy to use and can be activated by very low flow. However, young children may not be able to use them efficiently. The use of spacers reduces oropharyngeal deposition and improves drug delivery to the lung. Spacers do not require patient coordination, but some general rules must be followed for their optimal use. Dry powder inhalers (DPI) are portable and easy to use. They are indicated either for rescue bronchodilators therapy or for regular treatment with inhaled corticosteroids and long-acting bronchodilators. For the application of liquid preparation for inhalation a wide variety of nebulizers are available in asthma therapy. The choice of a delivery device mainly depends on the age of the patient, the drug to be administered and the condition to be treated. As the therapy efficacy mainly depends on drug device optimal use, proper education of pharmacist and his rediness/duty to demonstrate the device usage is also essential for children and parents, too. AB - Budući da ima niz prednosti, inhalacioni put primene lekova je prvi izbor u terapiji hronične astme: brz početak delovanja leka, a potrebne su niže doze i time manja mogućnost ispoljavanja neželjenih efekata u poređenju sa dragim putevima primene. Nažalost, pomoćni uređaji za inhalaciju češće se koriste empirijski nego na osnovu kliničkih dokaza. Merno-dozni inhalatori (MDI), sprejovi za inhalaciju su još uvek široko rasprostranjen vid inhalacione primene lekova u terapiji astme. Praktični su, jevtini i višedozni sistemi. Međutim, postoji nekoliko problema vezano za njihovu primenu. Udahom-aktivirani MDI su jednostavni za primenu i mogu se aktivirati pri veoma slabom udanu. Nažalost, mala deca ih ne mogu koristiti efikasno. Upotrebom komora redukuje se deponovanje lekova u orofarinksu i poboljšava raspodela leka u pluća. Komore ne zahtevaju koordinaciju pokreta na relaciji raspršivanje/inhalacija od strane pacijenta, ali se neka generalna pravila moraju poštovati u cilju postizanja očekivanog terapijskog odgovora. Praškovi za inhalaciju (DPI) su laki za primenu i prihvatljive su veličine. Indikovani su u akutnim stanjima za primenu bronhodilatatora ili za terapiju održavanja kod hronične astme, koja se tretira kortikosteroidima ili dugo-delujućim bronhodilatatorima. U terapiji astme na raspolaganju je nekoliko tipova nebulizera za primenu tečnih preparata za inhalaciju. Izbor optimalnog uređaja uglavnom zavisi od uzrasta deteta, leka koji treba da se primeni i stanja koje treba tretirati. Budući da efekat terapije u velikoj meri zavisi od načina upotrebe uređaja za inhalaciju, adekvatna edukacija farmaceuta i njegova obučenost i spremnost/obaveza da pacijentu demonstrira primenu preparata je od izuzetne važnosti i za decu i za roditelje. PB - Savez farmaceutskih udruženja Srbije, Beograd T2 - Arhiv za farmaciju T1 - Pharmaceutical-technological aspects of drugs in inhalation therapy of asthma in children population T1 - Farmaceutsko-tehnološki aspekti lekova u inhalacionoj terapiji astme u dece VL - 55 IS - 4 SP - 389 EP - 409 UR - https://hdl.handle.net/21.15107/rcub_farfar_607 ER -
@article{ author = "Savić, Snežana and Savić, Miroslav and Vuleta, Gordana", year = "2005", abstract = "Inhalation is the preferred route for asthma therapy, since it offers a rapid onset of drug action, requires smaller doses, and reduces systemic effects compared with other routes of administration. Unfortunately, inhalation devices are frequently used in an empirical manner rather than on evidence-based awareness. Metered-dose inhalers (MDI) are practical, cheap and multidose. However, there are several problems with their use. Breath-actuated MDI are easy to use and can be activated by very low flow. However, young children may not be able to use them efficiently. The use of spacers reduces oropharyngeal deposition and improves drug delivery to the lung. Spacers do not require patient coordination, but some general rules must be followed for their optimal use. Dry powder inhalers (DPI) are portable and easy to use. They are indicated either for rescue bronchodilators therapy or for regular treatment with inhaled corticosteroids and long-acting bronchodilators. For the application of liquid preparation for inhalation a wide variety of nebulizers are available in asthma therapy. The choice of a delivery device mainly depends on the age of the patient, the drug to be administered and the condition to be treated. As the therapy efficacy mainly depends on drug device optimal use, proper education of pharmacist and his rediness/duty to demonstrate the device usage is also essential for children and parents, too., Budući da ima niz prednosti, inhalacioni put primene lekova je prvi izbor u terapiji hronične astme: brz početak delovanja leka, a potrebne su niže doze i time manja mogućnost ispoljavanja neželjenih efekata u poređenju sa dragim putevima primene. Nažalost, pomoćni uređaji za inhalaciju češće se koriste empirijski nego na osnovu kliničkih dokaza. Merno-dozni inhalatori (MDI), sprejovi za inhalaciju su još uvek široko rasprostranjen vid inhalacione primene lekova u terapiji astme. Praktični su, jevtini i višedozni sistemi. Međutim, postoji nekoliko problema vezano za njihovu primenu. Udahom-aktivirani MDI su jednostavni za primenu i mogu se aktivirati pri veoma slabom udanu. Nažalost, mala deca ih ne mogu koristiti efikasno. Upotrebom komora redukuje se deponovanje lekova u orofarinksu i poboljšava raspodela leka u pluća. Komore ne zahtevaju koordinaciju pokreta na relaciji raspršivanje/inhalacija od strane pacijenta, ali se neka generalna pravila moraju poštovati u cilju postizanja očekivanog terapijskog odgovora. Praškovi za inhalaciju (DPI) su laki za primenu i prihvatljive su veličine. Indikovani su u akutnim stanjima za primenu bronhodilatatora ili za terapiju održavanja kod hronične astme, koja se tretira kortikosteroidima ili dugo-delujućim bronhodilatatorima. U terapiji astme na raspolaganju je nekoliko tipova nebulizera za primenu tečnih preparata za inhalaciju. Izbor optimalnog uređaja uglavnom zavisi od uzrasta deteta, leka koji treba da se primeni i stanja koje treba tretirati. Budući da efekat terapije u velikoj meri zavisi od načina upotrebe uređaja za inhalaciju, adekvatna edukacija farmaceuta i njegova obučenost i spremnost/obaveza da pacijentu demonstrira primenu preparata je od izuzetne važnosti i za decu i za roditelje.", publisher = "Savez farmaceutskih udruženja Srbije, Beograd", journal = "Arhiv za farmaciju", title = "Pharmaceutical-technological aspects of drugs in inhalation therapy of asthma in children population, Farmaceutsko-tehnološki aspekti lekova u inhalacionoj terapiji astme u dece", volume = "55", number = "4", pages = "389-409", url = "https://hdl.handle.net/21.15107/rcub_farfar_607" }
Savić, S., Savić, M.,& Vuleta, G.. (2005). Pharmaceutical-technological aspects of drugs in inhalation therapy of asthma in children population. in Arhiv za farmaciju Savez farmaceutskih udruženja Srbije, Beograd., 55(4), 389-409. https://hdl.handle.net/21.15107/rcub_farfar_607
Savić S, Savić M, Vuleta G. Pharmaceutical-technological aspects of drugs in inhalation therapy of asthma in children population. in Arhiv za farmaciju. 2005;55(4):389-409. https://hdl.handle.net/21.15107/rcub_farfar_607 .
Savić, Snežana, Savić, Miroslav, Vuleta, Gordana, "Pharmaceutical-technological aspects of drugs in inhalation therapy of asthma in children population" in Arhiv za farmaciju, 55, no. 4 (2005):389-409, https://hdl.handle.net/21.15107/rcub_farfar_607 .
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