Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects
2005
Аутори
Bogavac-Stanojević, NatašaJelić-Ivanović, Zorana
Đurović, Srđan
Spasojević-Kalimanovska, Vesna
Spasić, Slavica
Kalimanovska-Oštrić, Dimitra
Memon, Lidija
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
High plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-c in some studies performed mostly in hyperlipidemic subjects, but this association has not yet been investigated in CAD patients. In addition, conflicting results were obtained from in vitro studies that explored the proposed HDL effect on cytokine-induced CAM expression. The aim of the present case-control study was to investigate whether low HDL-c values are associated with CAM overexpression in normolipidemic CAD patients and healthy individuals, matched according to age and gender. Plasma HDL-c, sICAM-1, sVCAM-1, and sE-selectin were measured in 37 normolipidemic patients with angiographically verified coronary artery disease and in 52 healthy normolipidemic subjects.... The sCAM values obtained in the subjects (patients or controls) with low HDL-c levels ( lt 1.03 mmol/L) were compared with the values in the subjects with high HDL-c (>= 1.03 mmol/L). No significant difference was found between sICAM-1, sVCAM-1, and E-selectin values obtained in subjects with low and high HDL-c, either among the patients or the healthy controls. In conclusion, low HDL-c levels are not associated with CAM overexpression in normolipidemic CAD patients and healthy subjects.
Кључне речи:
atherosclerosis / high-density lipoproteins / E-selectin / intracellular adhesion molecule-1 / vascular cell adhesion molecule-1Извор:
International Heart Journal, 2005, 46, 4, 593-600Издавач:
- International Heart Journal Association, Tokyo
DOI: 10.1536/ihj.46.593
ISSN: 1349-2365
PubMed: 16157950
WoS: 000232575300003
Scopus: 2-s2.0-33644878696
Институција/група
PharmacyTY - JOUR AU - Bogavac-Stanojević, Nataša AU - Jelić-Ivanović, Zorana AU - Đurović, Srđan AU - Spasojević-Kalimanovska, Vesna AU - Spasić, Slavica AU - Kalimanovska-Oštrić, Dimitra AU - Memon, Lidija PY - 2005 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/610 AB - High plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-c in some studies performed mostly in hyperlipidemic subjects, but this association has not yet been investigated in CAD patients. In addition, conflicting results were obtained from in vitro studies that explored the proposed HDL effect on cytokine-induced CAM expression. The aim of the present case-control study was to investigate whether low HDL-c values are associated with CAM overexpression in normolipidemic CAD patients and healthy individuals, matched according to age and gender. Plasma HDL-c, sICAM-1, sVCAM-1, and sE-selectin were measured in 37 normolipidemic patients with angiographically verified coronary artery disease and in 52 healthy normolipidemic subjects. The sCAM values obtained in the subjects (patients or controls) with low HDL-c levels ( lt 1.03 mmol/L) were compared with the values in the subjects with high HDL-c (>= 1.03 mmol/L). No significant difference was found between sICAM-1, sVCAM-1, and E-selectin values obtained in subjects with low and high HDL-c, either among the patients or the healthy controls. In conclusion, low HDL-c levels are not associated with CAM overexpression in normolipidemic CAD patients and healthy subjects. PB - International Heart Journal Association, Tokyo T2 - International Heart Journal T1 - Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects VL - 46 IS - 4 SP - 593 EP - 600 DO - 10.1536/ihj.46.593 ER -
@article{ author = "Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Đurović, Srđan and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Kalimanovska-Oštrić, Dimitra and Memon, Lidija", year = "2005", abstract = "High plasma HDL-cholesterol (HDL-c) is a well-established protective factor in coronary artery disease (CAD). One of its potential protective mechanisms is the inhibition of the cytokine-induced upregulation of expression of cellular adhesion molecules (CAMs). High sCAM levels were found to be associated with low HDL-c in some studies performed mostly in hyperlipidemic subjects, but this association has not yet been investigated in CAD patients. In addition, conflicting results were obtained from in vitro studies that explored the proposed HDL effect on cytokine-induced CAM expression. The aim of the present case-control study was to investigate whether low HDL-c values are associated with CAM overexpression in normolipidemic CAD patients and healthy individuals, matched according to age and gender. Plasma HDL-c, sICAM-1, sVCAM-1, and sE-selectin were measured in 37 normolipidemic patients with angiographically verified coronary artery disease and in 52 healthy normolipidemic subjects. The sCAM values obtained in the subjects (patients or controls) with low HDL-c levels ( lt 1.03 mmol/L) were compared with the values in the subjects with high HDL-c (>= 1.03 mmol/L). No significant difference was found between sICAM-1, sVCAM-1, and E-selectin values obtained in subjects with low and high HDL-c, either among the patients or the healthy controls. In conclusion, low HDL-c levels are not associated with CAM overexpression in normolipidemic CAD patients and healthy subjects.", publisher = "International Heart Journal Association, Tokyo", journal = "International Heart Journal", title = "Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects", volume = "46", number = "4", pages = "593-600", doi = "10.1536/ihj.46.593" }
Bogavac-Stanojević, N., Jelić-Ivanović, Z., Đurović, S., Spasojević-Kalimanovska, V., Spasić, S., Kalimanovska-Oštrić, D.,& Memon, L.. (2005). Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects. in International Heart Journal International Heart Journal Association, Tokyo., 46(4), 593-600. https://doi.org/10.1536/ihj.46.593
Bogavac-Stanojević N, Jelić-Ivanović Z, Đurović S, Spasojević-Kalimanovska V, Spasić S, Kalimanovska-Oštrić D, Memon L. Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects. in International Heart Journal. 2005;46(4):593-600. doi:10.1536/ihj.46.593 .
Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Đurović, Srđan, Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Kalimanovska-Oštrić, Dimitra, Memon, Lidija, "Lack of association between low HDL-cholesterol and elevated circulating cellular adhesion molecules in normolipidemic CAD patients and healthy subjects" in International Heart Journal, 46, no. 4 (2005):593-600, https://doi.org/10.1536/ihj.46.593 . .